[1]丁小格,邱小平,杨振,等. HexaMotion系统模拟三维呼吸运动对乳腺癌根治术患者胸壁浅表剂量分布的影响[J].中国医学物理学杂志,2018,35(10):1134-1138.[doi:DOI:10.3969/j.issn.1005-202X.2018.10.004]
　DING Xiaoge,QIU Xiaoping,YANG Zhen,et al. Effects of three-dimensional respiratory motions simulated by HexaMotion system on superficial dose distribution of chest wall in patients receiving radical mastectomy for breast cancer[J].Chinese Journal of Medical Physics,2018,35(10):1134-1138.[doi:DOI:10.3969/j.issn.1005-202X.2018.10.004]
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 HexaMotion系统模拟三维呼吸运动对乳腺癌根治术患者胸壁浅表剂量分布的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第10期
页码:
1134-1138
栏目:
医学放射物理
出版日期:
2018-10-25

文章信息/Info

Title:
 Effects of three-dimensional respiratory motions simulated by HexaMotion system on superficial dose distribution of chest wall in patients receiving radical mastectomy for breast cancer
文章编号:
1005-202X（2018）10-1134-05
作者:
 丁小格1; 邱小平1; 杨振2; 曹瑛2
 1.南华大学核科学与技术学院， 湖南 衡阳 421001； 2.中南大学湘雅医院放射治疗中心， 湖南 长沙 421000
Author(s):
 DING Xiaoge1;  QIU Xiaoping1;  YANG Zhen2;  CAO Ying2
 1. School of Nuclear Science and Technology, University of South China, Hengyang 421001, China; 2. Radiotherapy Centre, Xiangya Hospital, Central South University, Changsha 421000, China
关键词:
 ; HexaMotion系统; MOSFET探测器; 呼吸运动; 乳腺癌; 浅表剂量
Keywords:
 ; Keywords: HexaMotion system;  MOSFET detector;  respiratory motion;  breast cancer;  superficial dose
分类号:
R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2018.10.004
文献标志码:
A
摘要:
 目的：用HexaMotion系统模拟乳腺癌根治术患者三维呼吸运动，并结合金属氧化物导体场效应晶体管，研究呼吸运动对乳腺肿瘤放射治疗时胸壁浅表剂量分布的影响。 方法：调研57例乳腺癌患者胸壁在X、Y和Z方向的平均运动幅度，结合RPM系统测量9例乳腺癌患者的平均呼吸振幅，利用呼吸运动产生器合成三维运动曲线，再将呼吸曲线文件输入ScandiDoseHexaMotion软件，驱动Delta4模体模拟病人的呼吸运动。为模拟左（右）乳腺癌患者胸壁内侧、中间、外侧测量位置，在Delta4处于机架角为0°、30°（330°）和60°（300°）下十字铅丝投影下的位置固定MOSFET剂量仪，执行计划，测量模体在静止与运动状态下的剂量，评估呼吸运动对乳腺胸壁浅表剂量分布的影响。 结果：模体在静止和平均运动振幅状态下的相对剂量差异基本在±3%左右，整体在±5%以内，且在0°、30°（330°）和60°（300°）静止与运动状态下测量值的差异无显著意义（P值分别为0.73、0.28和0.52）；胸壁运动振幅在一定范围内，混合调强计划对胸壁浅表剂量分布影响不大，但随着振幅增加，当运动振幅增加到cm数量级，胸壁浅表剂量分布明显增加。 结论：呼吸曲线振幅轻微的改变并不会造成胸壁浅表剂量明显的变化，但随着呼吸运动振幅的显著增加，胸壁浅表剂量分布也随之增加。
Abstract:
Abstract： Objective To simulate the three-dimensional respiratory motions of patients receiving radical mastectomy by HexaMotion system, and to combine HexaMotion system with metal oxide semiconductor filed effect transistor for studying the effects of respiratory motions on the superficial dose distribution of the chest wall during the radiotherapy for breast cancer. Methods The average motion amplitude of the chest in 57 patients with breast cancer in X, Y and Z directions were investigated, and RPM system was used to measure the average respiratory amplitude of 9 patients with breast cancer. The respiratory motion generator was used to generate three-dimensional motion curves which were then input into ScandiDoseHexaMotion software to drive the Delta4 phantom to simulate the respiratory motions of patients. The MOSFET dosimeter was fixed at the surface of Delta4 which was at cross-hatch angles of 0°, 30° (330°), and 60° (300°) to measure the doses at the medial, middle and lateral side of chest wall in the patients with left (right) breast cancers. Then plans were implemented, and the doses of phantom at rest and in motion state were measured. The effects of respiratory motions on the superficial dose distribution of the chest wall were evaluated. Results The relative dose differences of phantom at rest and in motion state was basically about ±3%, and all of them were within ±5%. No significant differences were found in the measurements between rest state and motion state with Delta4 at cross-hatch angles of 0°, 30° (330°), and 60 ° (300°) (P=0.73, 0.28 and 0.52). When the respiratory amplitude was in a certain range, hybrid intensity-modulated radiotherapy had little effects on the superficial dose distribution of chest wall. However, when the respiratory amplitude was increased to cm magnitude, the superficial dose distribution of chest wall would be significantly increased with the increase of amplitude. Conclusion The slight changes of respiratory amplitude don’t cause obvious changes in chest wall superficial dose, but with the significant increase of respiratory amplitude, the superficial dose distribution of chest wall also increases.

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备注/Memo

备注/Memo:
 【收稿日期】2018-04-25
【作者简介】丁小格，硕士，研究方向：医学物理，E-mail: huanboom@163.com
更新日期/Last Update: 2018-10-22