[1]李莎,王美娇,岳海振,等. Eclipse新光子优化算法中优化分辨率对放疗计划的影响[J].中国医学物理学杂志,2017,34(11):1081-1085.[doi:DOI:10.3969/j.issn.1005-202X.2017.11.001]
　LI Sha,WANG Meijiao,et al. Dosimetric impact of optimization resolutions of the new photon optimizer in Eclipse treatment planning system[J].Chinese Journal of Medical Physics,2017,34(11):1081-1085.[doi:DOI:10.3969/j.issn.1005-202X.2017.11.001]
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 Eclipse新光子优化算法中优化分辨率对放疗计划的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
34卷
期数:
2017年第11期
页码:
1081-1085
栏目:
医学放射物理
出版日期:
2017-11-20

文章信息/Info

Title:
 Dosimetric impact of optimization resolutions of the new photon optimizer in Eclipse treatment planning system
文章编号:
1005-202X（2017）11-1081-05
作者:
 李莎1; 3; 王美娇2; 3; 岳海振3; 黄宇亮3; 刘卓伦3; 张健3; 高嵩1; 张艺宝3
 1.北京大学医学部医学物理系， 北京 100191； 2.中国疾病预防控制中心辐射防护与核安全医学所， 北京 100088； 3.北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科/恶性肿瘤发病机制及转化研究教育部重点实验室， 北京 100142
Author(s):
 LI Sha1;  3;  WANG Meijiao2; 3;  YUE Haizhen3;  HUANG Yuliang3;  LIU Zhuolun3;  ZHANG Jian3;  GAO Song1;  ZHANG Yibao3
 1. Department of Medical Physics, Peking University Health Science Center, Beijing 100191, China; 2. National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China; 3. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China
关键词:
 ; 新光子优化算法; 优化分辨率; RapidPlan; 放疗
Keywords:
 ; new photon optimizer;  optimization resolution;  RapidPlan;  radiotherapy
分类号:
R312
DOI:
DOI:10.3969/j.issn.1005-202X.2017.11.001
文献标志码:
A
摘要:
 目的：研究Eclipse新光子优化算法（Photon Optimizer, PO）不同优化分辨率对直肠癌术前同步推量容积调强计划靶区（PTV）和危及器官受量的影响，指导临床选取合适的优化分辨率，保证计划质量，提高效率。 方法：利用RapidPlan模型，分别在1.25、2.50和5.00 mm优化分辨率设置下预测剂量体积直方图（DVH），通过Application Programming Interface脚本输出。用不同优化分辨率对20例患者进行计划设计，导出各计划表单DVH并用自编的MATLAB程序计算平均DVH，用SigmaPlot和SPSS软件绘图和统计分析。记录并比较各分辨率DVH的预测、计划优化时间。 结果：不同优化分辨率生成的DVH预测区间及优化参数完全相同，且预测时间差异不大，但使用1.25 mm分辨率完成计划优化大约是2.50和5.00 mm分辨率的3~4倍。3种优化分辨率均能满足临床处方剂量，PTV和计划肿瘤靶区（PGTV）的适形度指数、PTV的均匀性指数差异均没有统计学意义。PGTV的均匀性指数存在统计学差异，但差异幅度在0.01以内，无临床意义。1.25 mm分辨率并不总能取得最好的危及器官保护，平均DVH图差异也十分微小。 结论：靶区和危及器官剂量受优化分辨率影响很小，但时间差异明显。2.50 mm优化分辨率的性价比最高。
Abstract:
Abstract: Objective To investigate the effect of optimization resolutions of new photon optimizer in Eclipse treatment planning system on the dose to planning target volume (PTV) and organs-at-risk (OAR) of preoperational simultaneous-integrated-boosting volumetric modulated arc therapy plans for patients with rectal cancer, and provide clinical guidelines of resolution selection to strike a balance between plan quality and efficiency. Methods After the RapidPlan model applied in the research was set with a resolution of 1.25, 2.50 and 5.00 mm, respectively, the dose-volume histogram (DVH) were estimated, respectively, and Application Programming Interface (API) script was used to export these data for comparison. Herein, 3 plans using different resolutions were generated for 20 patients, and their DVH was exported. We applied the in-house MATLAB code to calculate the mean DVH, and SigmaPlot and SPSS software for plotting and statistical analysis. Time for DVH estimation and optimization were also recorded and analyzed. Results According to the API exportation, the DVH estimation and optimized parameters acquired by various resolutions were exactly the same. However, the optimization time using a resolution of 1.25 mm was about 3-4 times of that using the resolution of 2.50 and 5.00 mm. All the resolutions satisfied clinical requirements for target dose coverage. The differences in the conformity index of PTV and planning gross tumor volume, and the homogeneity index of PTV were not statistically significant (P>0.05). Though the homogeneity index of planning gross tumor volume was significantly different among 3 plans, the magnitude of deviations was within 0.01, which was considered clinically negligible. Relative to the resolutions of 2.50 and 5.00 mm, 1.25 mm did not always guarantee the best OAR sparing. The differences in mean DVH were marginal. Conclusion The impacts of optimization resolutions on the dose to target areas and OAR are trivial, but the differences in optimization time are dramatic. The plan with a resolution of 2.50 mm was most cost-effective.

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备注/Memo

备注/Memo:
 【收稿日期】2017-06-17
【基金项目】国家自然科学基金（11505012，61671026）；北京市自然科学基金（7172048，1174016，7162112）；北京市医院管理局“青苗”计划专项（QML20151004）；质检公益性行业科研专项（201510001-02）
【作者简介】李莎，硕士研究生，研究方向：医学物理，E-mail: 1446352137@qq.com
【通信作者】张艺宝，博士，高级工程师，硕士生导师，研究方向：医学物理，E-mail: ybzhang66@163.com
更新日期/Last Update: 2017-11-23