[1]王祖榛,王雨欣,宁晓琳.具有可调高精度的多模式经颅电刺激设备设计[J].中国医学物理学杂志,2025,42(9):1212-1220.[doi:DOI:10.3969/j.issn.1005-202X.2025.09.013]
　WANG Zuzhen,WANG Yuxin,NING Xiaolin,et al.Design of a multimodal transcranial electrical stimulation device with adjustable high precision[J].Chinese Journal of Medical Physics,2025,42(9):1212-1220.[doi:DOI:10.3969/j.issn.1005-202X.2025.09.013]
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具有可调高精度的多模式经颅电刺激设备设计()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
42
期数:
2025年第9期
页码:
1212-1220
栏目:
医学信号处理与医学仪器
出版日期:
2025-09-30

文章信息/Info

Title:
Design of a multimodal transcranial electrical stimulation device with adjustable high precision
文章编号:
1005-202X（2025）09-1212-09
作者:
王祖榛1; 王雨欣1; 宁晓琳1; 2
1.北京航空航天大学仪器科学与光电工程学院， 北京 100191； 2.合肥国家实验室， 安徽 合肥 230088
Author(s):
WANG Zuzhen1;  WANG Yuxin1;  NING Xiaolin1;  2
1. School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China 2. Hefei National Laboratory, Hefei 230088, China
关键词:
神经调控; 可调高精度; 多模式经颅电刺激; 电刺激源; 阻抗监测
Keywords:
Keywords: neuromodulation adjustable high-precision multimodal transcranial electrical stimulation electrical stimulation source impedance monitoring
分类号:
R318.6
DOI:
DOI:10.3969/j.issn.1005-202X.2025.09.013
文献标志码:
A
摘要:
为满足神经调控领域对设备灵活性和精确性的更高需求，设计具有可调高精度的多模式经颅电刺激设备。设备以STM32F407ZGT6为核心控制器，搭载FreeRTOS操作系统，采用高精度数字模拟转换芯片AD5676R与增强型Howland恒流源电路构成的电刺激源，结合INA228芯片实现精确的阻抗在线监测。实验结果表明，设备支持单极性和双极性直流、交流、脉冲及噪声输出，在电流输出、频率控制、脉宽调控及阻抗监测方面表现出较高的精度，输出电流在-2~2 mA范围内以1 μA步长调节，频率在1~200、200~600和600~800 Hz范围内分别以0.1、0.5和1.0 Hz步长调节，脉宽在0.3~10.0、10~100和100~1 000 ms范围内分别以0.1、1.0和2.0 ms步长调节。
Abstract:
Abstract: A multi-mode transcranial electrical stimulation device with adjustable high precision is designed to meet the higher requirements for device flexibility and precision in the field of neuromodulation. With STM32F407ZGT6 as the core controller, the device is equipped with FreeRTOS operating system, and its electrical stimulation source is composed of a high-precision digital-to-analog converter chip AD5676R and an enhanced Howland constant current source circuit, and it incorporates the INA228 chip to achieve accurate impedance online monitoring. The experimental results show that the device supports unipolar and bipolar direct current, alternating current, pulse and noise outputs, while exhibiting high precision in current output, frequency control, pulse width regulation, and impedance monitoring. The output current is adjustable within the range of -2 to 2 mA at a step size of 1 μA the frequency can be adjusted in the ranges of 1-200, 200-600, and 600-800 Hz, with corresponding step sizes of 0.1, 0.5 and 1.0 Hz, respectively and pulse width is adjustable within the ranges of 0.3-10.0, 10-100, and 100-1 000 ms, with corresponding step sizes of 0.1, 1.0 and 2.0 ms, respectively.

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备注/Memo

备注/Memo:
【收稿日期】2025-03-22 【基金项目】科技创新2030“量子通信与量子计算机”重大项目（2021ZD0300503） 【作者简介】王祖榛，硕士研究生，研究方向：嵌入式技术应用，E-mail: wangzuzhen999@163.com 【通信作者】宁晓琳，教授，研究方向：极弱磁功能成像、信号处理及医学应用，E-mail: ningxiaolin@buaa.edu.cn
更新日期/Last Update: 2025-09-30