[1]林洁,乌筱莹,丁丽麒.血液循环驱动泵联合治疗对脊柱结核术后患者深静脉血栓的预防效果及预后影响[J].中国医学物理学杂志,2023,40(8):1022-1025.[doi:DOI:10.3969/j.issn.1005-202X.2023.08.016]
　LIN Jie,WU Xiaoying,DING Liqi.Effect of rivaroxaban combined with blood circulation driven pump on prevention and prognosis of deep vein thrombosis after surgery for spinal tuberculosis[J].Chinese Journal of Medical Physics,2023,40(8):1022-1025.[doi:DOI:10.3969/j.issn.1005-202X.2023.08.016]
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血液循环驱动泵联合治疗对脊柱结核术后患者深静脉血栓的预防效果及预后影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
40卷
期数:
2023年第8期
页码:
1022-1025
栏目:
医学生物物理
出版日期:
2023-09-01

文章信息/Info

Title:
Effect of rivaroxaban combined with blood circulation driven pump on prevention and prognosis of deep vein thrombosis after surgery for spinal tuberculosis
文章编号:
1005-202X（2023）08-1022-04
作者:
林洁; 乌筱莹; 丁丽麒
同济大学附属上海市肺科医院/上海市红十字肺科医院/上海市职业病防治院， 上海 200433
Author(s):
LIN Jie;  WU Xiaoying;  DING Liqi
Shanghai Pulmonary Hospital Affiliated to Tongji University/Shanghai Red Cross Pulmonary Hospital/Shanghai Hospital of Prevention and Treatment for Occupational Disease, Shanghai 200433, China
关键词:
脊柱结核; 血液循环驱动泵; 利伐沙班; 深静脉血栓; 凝血功能; 血液黏稠度; 不良反应
Keywords:
Keywords: spinal tuberculosis blood circulation driven pump rivaroxaban deep vein thrombosis coagulation function blood viscosity adverse reaction
分类号:
R619.2
DOI:
DOI:10.3969/j.issn.1005-202X.2023.08.016
文献标志码:
A
摘要:
目的：探讨血液循环驱动泵联合治疗对脊柱结核术后患者深静脉血栓的预防效果及预后的影响。方法：90例脊柱结核患者作为研究对象，以简单随机数字表法分两组，各45例。所有患者均由同一术者行脊柱结核术治疗，对照组给予利伐沙班抗凝治疗，观察组在对照组治疗基础上联合血液循环驱动泵治疗。比较两组肺栓塞、深静脉血栓发生率，记录治疗前后血液流变学指标［血浆黏度、全血高切、低切黏度及纤维蛋白原（FIB）］及凝血酶原时间（PT）和D-二聚体水平变化，统计两组不良反应发生情况。结果：观察组肺栓塞、深静脉血栓发生率分别为2.22%、4.44%，均低于对照组（P<0.05）；治疗后，两组患者血浆黏度、全血高切、低切黏度及FIB均较治疗前降低，且观察组低于对照组（P<0.05）；治疗后，两组患者D-二聚体水平均降低，且观察组低于对照组（P<0.05）；观察组不良反应发生率低于对照组（6.67% vs 24.44%, P<0.05）。结论：血液循环驱动泵联合治疗脊柱结核术患者可有效改善患者的凝血功能，降低血液黏稠度，降低术后肺栓塞、深静脉血栓及不良反应发生。
Abstract:
Abstract: Objective To investigate the effect of the combined treatment of rivaroxaban and blood circulation driven pump on prevention and prognosis of deep vein thrombosis after surgery in patients with spinal tuberculosis. Methods Ninety cases of spinal tuberculosis were enrolled and randomly divided into 2 groups, with 45 cases in each group. All patients received surgery by the same surgeon. Rivaroxaban was used in control group for anticoagulant therapy, while rivaroxaban combined with blood circulation driven pump was adopted in observation group. The incidence of pulmonary embolism and deep vein thrombosis were compared between 2 groups and the changes of hemorheological indexes [plasma viscosity, low-shear and high-shear blood viscosities, and fibrinogen], prothrombin time and D-dimer level before and after treatment, and adverse reactions were recorded. Results The incidences of pulmonary embolism and deep vein thrombosis in observation group were 2.22% and 4.44%, lower than those in control group (P<0.05). After treatment, the plasma viscosity, low-shear and high-shear blood viscosities, fibrinogen and D-dimer level in both groups decreased, and the indexes were lower in observation group than control group (P<0.05). The incidence of adverse reactions in observation group was lower than that in control group (6.67% vs 24.44%, P<0.05). Conclusion The combined treatment of rivaroxaban and blood circulation driven pump in patients with spinal tuberculosis can effectively improve the blood coagulation function, reduce blood viscosity, and prevent postoperative pulmonary embolism, deep venous thrombosis and adverse reactions.

相似文献/References:

[1]张振显,宋鹏. 脊柱结核与脊柱转移瘤的磁共振弥散加权成像影像学特征分析[J].中国医学物理学杂志,2018,35(6):676.[doi:DOI:10.3969/j.issn.1005-202X.2018.06.011]
　ZHANG Zhenxian,SONG Peng. Imaging features of magnetic resonance imaging-diffusion weighted imaging on spinal tuberculosis and spinal metastatic tumor[J].Chinese Journal of Medical Physics,2018,35(8):676.[doi:DOI:10.3969/j.issn.1005-202X.2018.06.011]

备注/Memo

备注/Memo:
【收稿日期】2023-04-17 【基金项目】上海“科技创新行动计划”自然科学基金（202K144801） 【作者简介】林洁，护师，研究方向：肺结核与肺外结核康复护理，E-mail: peimengpm@yeah.net 【通信作者】丁丽麒，主管护师，研究方向：肺结核与肺外结核康复护理，E-mail: 527993654@qq.com
更新日期/Last Update: 2023-09-06