[1]杨杰,郭丽宁,许汴菊.CT引导下三维腔内后装放疗联合体外调强化疗在治疗晚期宫颈癌的应用价值[J].中国医学物理学杂志,2022,39(10):1213-1216.[doi:DOI:10.3969/j.issn.1005-202X.2022.10.006]
　YANG Jie,GUO Lining,XU Bianju.Clinical outcome of CT-guided three-dimensional intracavitary brachytherapy combined with intensity-modulated radiotherapy for advanced cervical cancer[J].Chinese Journal of Medical Physics,2022,39(10):1213-1216.[doi:DOI:10.3969/j.issn.1005-202X.2022.10.006]
点击复制

CT引导下三维腔内后装放疗联合体外调强化疗在治疗晚期宫颈癌的应用价值()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第10期
页码:
1213-1216
栏目:
医学放射物理
出版日期:
2022-11-02

文章信息/Info

Title:
Clinical outcome of CT-guided three-dimensional intracavitary brachytherapy combined with intensity-modulated radiotherapy for advanced cervical cancer
文章编号:
1005-202X（2022）10-1213-04
作者:
杨杰; 郭丽宁; 许汴菊
榆林市第一医院妇产科， 陕西 榆林 719000
Author(s):
YANG Jie;  GUO Lining;  XU Bianju
Department of Obstetrics and Gynecology, the First Hospital of Yulin, Yulin 719000, China
关键词:
宫颈癌; CT引导; 三维腔内后装放疗; 调强放射治疗; 顺铂
Keywords:
Keywords: cervical cancer CT-guided three-dimensional intracavitary brachytherapy intensity-modulated radiotherapy cisplatin
分类号:
R816.91
DOI:
DOI:10.3969/j.issn.1005-202X.2022.10.006
文献标志码:
A
摘要:
【摘要】目的：探讨CT引导下三维腔内后装放疗联合体外调强放疗（IMRT）、顺铂治疗晚期宫颈癌的效果。方法：选取97例晚期宫颈癌患者进行回顾性研究，其中55例患者采用CT引导下三维腔内后装放疗联合IMRT、顺铂治疗（观察组），42例患者采用二维腔内后装放疗联合IMRT、顺铂治疗（对照组）。观察并比较两组患者治疗前后效果、危及器官放射损伤程度、患者3年预后结局差异。结果：经过联合放化疗，观察组治疗有效率显著高于对照组（98.18% vs 88.10%, P<0.05）。放疗过程中，观察组小肠、膀胱、直肠接受放疗的平均受照射剂量、2.0 cm3受照射剂量均显著低于对照组（P<0.05），观察组骨髓抑制、放射性直肠炎、放射性膀胱炎的发生程度均显著低于对照组（P<0.05）；随访3年，两组生存率无统计学差异（P>0.05），观察组患者3年的中位生存时间长于对照组（P<0.05）。结论：CT引导下三维腔内后装放疗联合IMRT、顺铂治疗晚期宫颈癌的效果优于二维腔内后装放疗联合IMRT、顺铂治疗，对危及器官的放射性损伤程度更低，患者的生存时间更长。
Abstract:
Abstract: Objective To investigate the clinical outcome in advanced cervical cancer patients treated with CT-guided three-dimensional intracavitary brachytherapy combined with intensity-modulated radiotherapy (IMRT) and cisplatin chemotherapy. Methods Among 97 advanced cervical cancer patients selected for retrospective analysis, 55 patients received CT-guided three-dimensional intracavity brachytherapy combined with IMRT and cisplatin chemotherapy (observation group), and the other 42 patients were treated with two-dimensional intracavitary brachytherapy combined with IMRT and cisplatin chemotherapy (control group). The treatment outcome, radiation damage to organs-at-risk, and 3-year prognostic outcomes were compared between two groups. Results After radiochemotherapy, the proportion of CR+PR patients in observation group was 98.18%, higher than 88.10% in control group (P<0.05). The average radiation dose and 2.0 cm3 radiation dose to the small intestine, bladder and rectum were significantly lower in observation group than in control group (P<0.05), and the incidences of myelosuppression, radiation proctitis and radiation cystitis in observation group were significantly lower than those in control group (P<0.05). After 3 years of follow-up, the survival rate in observation group was close to that of control group (P>0.05), but the 3-year median survival time in observation group was longer than that in control group (P<0.05). Conclusion CT-guided three-dimensional intracavity brachytherapy combined with IMRT and cisplatin chemotherapy is more effective than two-dimensional intracavity brachytherapy combined with IMRT and cisplatin chemotherapy, with less radiation damage to organs-at-risk and longer survival time.

相似文献/References:

[1]戴相昆,杨丰蔚,杜 镭,等.等效均匀剂量优化法在宫颈癌调强计划中的应用[J].中国医学物理学杂志,2015,32(02):290.[doi:10.3969/j.issn.1005-202X.2015.02.033]
[2]刘 浩,王 新,李公平,等.宫颈癌放疗高危临床靶区变化及其对累计吸收剂量的影响[J].中国医学物理学杂志,2015,32(03):379.[doi:10.3969/j.issn.1005-202X.2015.03.017]
[3]孙晓欢,周咏春,谭丽娜,等.容积旋转调强与固定野调强在宫颈癌术后放疗中的剂量学比较[J].中国医学物理学杂志,2014,31(01):4604.[doi:10.3969/j.issn.1005-202X.2014.01.003]
[4]刘 浩,王 新,李公平,等.用二维电离室矩阵验证宫颈癌腔内放疗剂量分布[J].中国医学物理学杂志,2014,31(04):4988.[doi:10.3969/j.issn.1005-202X.2014.04.004]
[5]余 辉,张书旭.宫颈癌后装治疗剂量的调强优化方法[J].中国医学物理学杂志,2014,31(05):5114.[doi:10.3969/j.issn.1005-202X.2014.05.004]
[6]查元梓,张松方,屠永清,等.子野权重优化对CMS XiO宫颈癌调强计划的影响[J].中国医学物理学杂志,2013,30(01):3866.[doi:10.3969/j.issn.1005-202X.2013.01.007]
[7]张富利,刘清智,张伟超,等.宫颈癌术后盆腔螺旋断层调强放疗两种计划设计方法的剂量学分析[J].中国医学物理学杂志,2013,30(04):4229.[doi:10.3969/j.issn.1005-202X.2013.04.003]
[8]王佳浩,赖建军,唐荣军,等.结合EPID与EUD方法确定宫颈癌病例靶区最佳生物外放边界的研究[J].中国医学物理学杂志,2013,30(05):4378.[doi:10.3969/j.issn.1005-202X.2013.05.009]
[9]张富利,刘清智,王雅棣,等.基于配置不同类型MLC叶片加速器的宫颈癌术后调强放疗计划评估[J].中国医学物理学杂志,2013,30(05):4383.[doi:10.3969/j.issn.1005-202X.2013.05.010]
[10]刘致滨,王占宇,龙雨松.两种优化技术在宫颈癌术后IMRT计划中的比较[J].中国医学物理学杂志,2015,32(04):534.[doi:10.3969/j.issn.1005-202X.2015.04.018]
　[J].Chinese Journal of Medical Physics,2015,32(10):534.[doi:10.3969/j.issn.1005-202X.2015.04.018]

备注/Memo

备注/Memo:
【收稿日期】2022-03-06 【作者简介】杨杰，硕士，主治医师，研究方向：妇科疾病综合治疗，E-mail: yj00026@163.com 【通信作者】许汴菊，硕士，研究方向：盆底修复及治疗，E-mail: xx2020@foxmail.com
更新日期/Last Update: 2022-10-27