[1]陈蕾,余行,傅玉川,等.利用蒙特卡罗模拟评估空气间隙对点扫描质子治疗的剂量影响[J].中国医学物理学杂志,2022,39(9):1083-1088.[doi:DOI:10.3969/j.issn.1005-202X.2022.09.005]
 CHEN Lei,YU Hang,et al.Evaluating the effects of air gap on dose of spot scanning proton therapy using Monte Carlo simulation[J].Chinese Journal of Medical Physics,2022,39(9):1083-1088.[doi:DOI:10.3969/j.issn.1005-202X.2022.09.005]
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利用蒙特卡罗模拟评估空气间隙对点扫描质子治疗的剂量影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第9期
页码:
1083-1088
栏目:
医学放射物理
出版日期:
2022-11-02

文章信息/Info

Title:
Evaluating the effects of air gap on dose of spot scanning proton therapy using Monte Carlo simulation
文章编号:
1005-202X(2022)09-1083-06
作者:
陈蕾12余行1傅玉川1韩纪锋2
1.四川大学华西医院放疗科, 四川 成都 610041; 2.四川大学原子核科学技术研究所/辐射物理及技术教育部重点实验室, 四川 成都 610064
Author(s):
CHEN Lei1 2 YU Hang1 FU Yuchuan1 HAN Jifeng2
1. Department of Radiation Oncology, West China Hospital, Sichuan University, Chengdu 610041, China2. Key Laboratory of Radiation Physics and Technology of the Ministry of Education/Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China
关键词:
点扫描质子治疗蒙特卡罗模拟剂量修正因子空气间隙射程移位器Geant4
Keywords:
Keywords: spot scanning proton therapy Monte Carlo simulation dose correction factor air gap range shifter Geant4
分类号:
R318;R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2022.09.005
文献标志码:
A
摘要:
目的:利用蒙特卡罗模拟探究空气间隙对点扫描质子治疗的剂量影响。方法:利用通用蒙特卡罗程序Geant4平台构建使用射程移位器的治疗头末端的点扫描质子束流模型,并进行验证。模拟计算不同能量、不同射程移位器、不同束斑尺寸、不同束斑数目在不同空气间隙条件下的质子束流在水模体中的剂量沉积,并通过获得的积分深度剂量生成剂量修正因子对剂量的差异进行比较。结果:不同空气间隙会造成剂量损失,随空气间隙增大而增大,随水模体中深度增加而减小。对于能量更高的射束和使用水等效厚度更薄的射程移位器,剂量损失越大。束斑尺寸改变和束斑数目增加较少时造成的剂量损失与同条件下单一束流无显著差别。结论:当使用射程移位器、肿瘤位置较浅、空气间隙较大时,建议建立剂量修正因子数据库应用于治疗计划系统对剂量进行修正。
Abstract:
Abstract: Objective To explore the effects of air gap on the dose of spot scanning proton therapy by Monte Carlo simulation.Methods Monte Carlo program Geant4 platform was used to establish aspot scanning proton model at the end of beam nozzle when using range shifter, and the model was verified. In the cases of phantom beams with different energies, range shifters, spot sizes, spot numbers under different air gaps, the dose deposition in the water model was calculated, and the dose difference was analyzed using dose correction factor generated by integrated depth dose. Results Different air gaps resulted in dose loss, and the dose loss increased as the increase of air gap and decreased as increasing depth in the water phantom. For higher beam energy and the range shifter with a thinner water equivalent thickness, the dose loss was greater. The dose loss caused by the change of spot size and the small increase of spot number did not differ significantly with a single beam in the same case. Conclusion When the range shifter is used, the tumor is in the superficial, and the air gap is large, it is recommended to establish a dose correction factor database and apply it to the treatment planning system to correct the dose.

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备注/Memo

备注/Memo:
【收稿日期】2022-01-13 【基金项目】四川大学华西医院临床新技术项目(医临新2021-314号);四川省科技计划重点研发项目(2020YFS0274) 【作者简介】陈蕾,研究方向:质子重离子,E-mail: chenlei2020@stu.scu.edu.cn 【通信作者】傅玉川,E-mail: ychfu@hotmail.com
更新日期/Last Update: 2022-09-27