[1]张发恩.调强放疗联合卡培他滨治疗对晚期鼻咽癌患者外周血CD4+/CD8+的影响[J].中国医学物理学杂志,2022,39(8):946-949.[doi:DOI:10.3969/j.issn.1005-202X.2022.08.005]
 ZHANG Faen.Effects of intensity-modulated radiotherapy combined with capecitabine on peripheral blood CD4+/CD8+ in patients with advanced nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2022,39(8):946-949.[doi:DOI:10.3969/j.issn.1005-202X.2022.08.005]
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调强放疗联合卡培他滨治疗对晚期鼻咽癌患者外周血CD4+/CD8+的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第8期
页码:
946-949
栏目:
医学放射物理
出版日期:
2022-08-04

文章信息/Info

Title:
Effects of intensity-modulated radiotherapy combined with capecitabine on peripheral blood CD4+/CD8+ in patients with advanced nasopharyngeal carcinoma
文章编号:
1005-202X(2022)08-0946-04
作者:
张发恩
河池市人民医院肿瘤科, 广西 河池 547000
Author(s):
ZHANG Faen
Department of Oncology, Hechi Peoples Hospital, Hechi 547000, China
关键词:
鼻咽癌调强放射治疗卡培他滨外周血CD4+/CD8+
Keywords:
Keywords: nasopharyngeal carcinoma intensity-modulated radiotherapy capecitabine peripheral blood CD4+/CD8+
分类号:
R816.96
DOI:
DOI:10.3969/j.issn.1005-202X.2022.08.005
文献标志码:
A
摘要:
目的:探讨调强放疗联合卡培他滨治疗对晚期鼻咽癌患者外周血CD4+/CD8+的影响。方法:采用随机数表法将90例确诊的晚期鼻咽癌患者分为观察组(45例)和对照组(45例)。对照组患者进行单纯调强放疗,观察组患者采用调强放疗联合卡培他滨治疗,持续治疗6周。比较两组临床疗效、治疗前后外周血CD4+/CD8+水平;记录两组治疗期间不良反应发生情况及生存、复发、转移情况。结果:观察组患者治疗有效率为71.11%,显著高于对照组患者的53.33%(P<0.05);治疗后,观察组患者外周血CD4+、CD4+/CD8+比例显著高于对照组,外周血CD8+比例显著低于对照组(P<0.05);观察组治疗期间骨髓抑制、白细胞减少等不良反应发生率为33.33%,与对照组的27.78%无统计学差异(P>0.05);观察组患者1年无局部区域复发生存率、1年无远处转移生存率及1年无病生存率均大于对照组(P<0.05)。结论:调强放疗联合卡培他滨治疗可以明显提高晚期鼻咽癌患者的临床疗效,改善患者的免疫功能。
Abstract:
Abstract: Objective To explore the effects of the combination of intensity-modulated radiotherapy (IMRT) and capecitabine on peripheral blood CD4+/CD8+ in patients with advanced nasopharyngeal carcinoma (NPC). Methods According to the random number table, 90 patients with advanced NPC were divided into observation group (45 cases) and control group (45 cases). The patients in control group received IMRT alone, and those in observation group received IMRT combined with capecitabine for 6 weeks. The clinical efficacy, levels of peripheral blood CD4+/CD8+ before and after treatment were compared between two groups. The incidence of adverse reactions during treatment, survival, recurrence and metastasis in both groups were recorded. Results The response rate of treatment was significantly higher in observation group than control group (71.11% vs 53.33%, P<0.05). After treatment, the levels of peripheral blood CD4+ and CD4+/CD8+ in observation group were significantly higher than those in control group, while the level of peripheral blood CD8+ was significantly lower than that in control group (P<0.05). The total incidence of adverse reactions such as myelosuppression and leukopenia in observation group was lower than that in control group, but there was no significant difference (33.33% vs 27.78%, P>0.05). The 1-year local non-recurrence, distant non-metastasis and disease-free survival rates in observation group were all higher than those in control group (P<0.05). Conclusion IMRT combined with capecitabine can significantly improve clinical efficacy in patients with advanced NPC, and effectively improve the immune function.

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备注/Memo

备注/Memo:
【收稿日期】2021-12-25 【基金项目】广西壮族自治区卫生健康委科研课题(Z20211037) 【作者简介】张发恩,副主任医师,研究方向:肿瘤放射治疗,E-mail:ff03698@163.com
更新日期/Last Update: 2022-09-05