[1]胡小洋,韩磊,汪洋,等.TTF电极阵列及头皮保护技术对放疗剂量分布影响的初步研究[J].中国医学物理学杂志,2022,39(2):169-176.[doi:DOI:10.3969/j.issn.1005-202X.2022.02.007]
　HU Xiaoyang,HAN Lei,WANG Yang,et al.Preliminary study on the effects of electrodes array for tumor treating fields and scalp sparing technology on the dose distribution in radiotherapy[J].Chinese Journal of Medical Physics,2022,39(2):169-176.[doi:DOI:10.3969/j.issn.1005-202X.2022.02.007]
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TTF电极阵列及头皮保护技术对放疗剂量分布影响的初步研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第2期
页码:
169-176
栏目:
医学放射物理
出版日期:
2022-02-26

文章信息/Info

Title:
Preliminary study on the effects of electrodes array for tumor treating fields and scalp sparing technology on the dose distribution in radiotherapy
文章编号:
1005-202X（2022）02-0169-08
作者:
胡小洋1; 韩磊1; 汪洋1; 2; 孙磊3; 倪春霞1; 刘颖4
1.上海伽玛医院放疗科， 上海 200235； 2.复旦大学附属华山医院放射治疗中心， 上海 200040； 3.复旦大学附属华山医院射波刀中心， 上海 200040； 4.上海理工大学医疗器械与食品学院， 上海 200093
Author(s):
HU Xiaoyang1;  HAN Lei1;  WANG Yang1; 2;  SUN Lei3;  NI Chunxia1;  LIU Ying4
1. Department of Radiotherapy, Shanghai Gamma Hospital, Shanghai 200235, China 2. Center of Radiotherapy, Huashan Hospital of Fudan University, Shanghai 200040, China 3. Center of Cyberknife, Huashan Hospital of Fudan University, Shanghai 200040, China 4. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
关键词:
肿瘤治疗电场; 胶质母细胞瘤; 容积旋转调强; 剂量分布; 头皮保护技术
Keywords:
Keywords: tumor treating field glioblastoma volumetric modulated arc therapy dose distribution scalp sparing technology
分类号:
R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2022.02.007
文献标志码:
A
摘要:
目的：研究肿瘤治疗电场（TTF）电极阵列及头皮保护技术对放疗剂量分布的影响。方法：实测TTF电极对于剂量分布的影响；在没有TTF电极阵列的CT上设计容积旋转调强计划，在有TTF电极阵列的CT上重新计算，比较TTF电极阵列对于剂量分布的影响；比较TTF电极阵列不同位置对计划剂量分布的影响；设计头皮保护计划，探讨保护前后靶区和头皮剂量的差异。结果：TTF电极阵列使靶区Dmean降低约0.55%，头皮的D20 cc、D30 cc、Dmean和Dmax升高8.8%、8.9%、8.1%和4.0%，TTF电极阵列位置改变对剂量分布影响不大。头皮保护计划可明显降低头皮剂量，D20 cc、D30 cc、Dmean和Dmax下降8.4%、7.0%、4.2%和19.7%。结论：TTF电极阵列对靶区剂量分布的影响是可接受的，但会使头皮剂量明显增加，采用头皮保护计划，能明显降低头皮剂量，值得进一步研究。
Abstract:
Abstract: Objective To study the effects of electrodes array for tumor treating fields (TTF) and scalp sparing technology on the radiation dose distribution. Methods The variations of dose distribution due to TTF electrodes array were measured in the study. Volumetric modulated arc therapy plans were designed on CT without TTF electrodes array and recalculated on CT with TTF electrodes array to investigate the effects of TTF electrodes array on dose distribution. The effect of different TTF electrodes array positions on the dose distribution was also analyzed. Moreover, scalp sparing plan was designed to compare the dose to the target areas and the scalp before and after scalp sparing. Results TTF electrodes array reduced the average dose to the target areas by about 0.55%, and increased the D20 cc, D30 cc, Dmean and Dmax to the scalp by 8.8%, 8.9%, 8.1% and 4.0%, respectively. The change of TTF electrode array position had little effect on the dose distribution. The comparison between scalp sparing or not showed that the D20 cc, D30 cc, Dmean and Dmax to the scalp in scalp sparing plan were decreased by 8.4%, 7.0%, 4.2% and 19.7%, respectively. Conclusion The effect of TTF electrodes array on the dose distribution in the target areas is acceptable, but it will make the scalp dose increase significantly. Scalp sparing plan can significantly reduce the scalp dose. It is worthy of a further study.

相似文献/References:

[1]许彦龙,李国强,余跃,等.肿瘤电场治疗在胶质母细胞瘤治疗中的应用进展[J].中国医学物理学杂志,2021,38(5):647.[doi:DOI:10.3969/j.issn.1005-202X.2021.05.023]
　XU Yanlong,,et al.Advances in application of tumor treating fields in glioblastoma[J].Chinese Journal of Medical Physics,2021,38(2):647.[doi:DOI:10.3969/j.issn.1005-202X.2021.05.023]
[2]杨丽姝,刘丽珠,韩波.肿瘤治疗电场的微观机制及临床应用进展[J].中国医学物理学杂志,2021,38(7):883.[doi:DOI:10.3969/j.issn.1005-202X.2021.07.018]
　YANG Lishu,LIU Lizhu,HAN Bo.Micromechanism of tumor treating fields and advances in its clinical application[J].Chinese Journal of Medical Physics,2021,38(2):883.[doi:DOI:10.3969/j.issn.1005-202X.2021.07.018]

备注/Memo

备注/Memo:
【收稿日期】2021-08-15 【作者简介】胡小洋，主管技师，研究方向：肿瘤放射物理，E-mail: hxy2006x@126.com 【通信作者】汪洋，主任医师，研究方向：中枢神经系统肿瘤的放疗和综合治疗，E-mail: janetcyj@163.com
更新日期/Last Update: 2022-03-07