[1]闫慧芳,刘洪源,杨志勇,等.基于日志文件分析PerFRACTION系统的敏感度和特异度[J].中国医学物理学杂志,2021,38(4):404-410.[doi:DOI:10.3969/j.issn.1005-202X.2021.04.002]
　YAN Huifang,LIU Hongyuan,et al.Analysis of sensitivity and specificity of PerFRACTION system based on log files[J].Chinese Journal of Medical Physics,2021,38(4):404-410.[doi:DOI:10.3969/j.issn.1005-202X.2021.04.002]
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基于日志文件分析PerFRACTION系统的敏感度和特异度()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第4期
页码:
404-410
栏目:
医学放射物理
出版日期:
2021-04-29

文章信息/Info

Title:
Analysis of sensitivity and specificity of PerFRACTION system based on log files
文章编号:
1005-202X（2021）04-0404-07
作者:
闫慧芳1; 2; 刘洪源2; 杨志勇2; 李勤2; 韩军2; 聂鑫2; 梁志文2; 张盛2
1.郑州大学第二附属医院肿瘤放疗科，河南 郑州450000； 2.华中科技大学同济医学院附属协和医院肿瘤中心， 湖北 武汉430022
Author(s):
YAN Huifang1;  2;  LIU Hongyuan2;  YANG Zhiyong2;  LI Qin2;  HAN Jun2;  NIE Xin2;  LIANG Zhiwen2;  ZHANG Sheng2
1. Department of Radiation Oncology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China 2. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
关键词:
PerFRACTION系统; 日志文件; γ分析; ROC曲线; 敏感度; 特异度
Keywords:
Keywords: PerFRACTION system log files gamma analysis receiver operating characteristic curve sensitivity specificity
分类号:
R815.6
DOI:
DOI:10.3969/j.issn.1005-202X.2021.04.002
文献标志码:
A
摘要:
目的：通过观察PerFRACTION系统检测出Trilogy加速器上执行VMAT计划的敏感度和特异度，得出该系统对VMAT计划剂量验证的诊断效能和γ通过标准。方法：随机选取两组不同解剖部位的VMAT计划（包括原始计划和引入随机误差的修改计划）。通过PerFRACTION系统检测原始计划和修改计划，测试该系统的敏感度和特异度。同时，ArcCHECK模体也测试了两组同样的计划，作为参考。结果：原始和修改计划的剂量分析分别采用3%/3 mm、3%/2 mm的γ分析标准进行分析，原始计划的γ通过率均在98%和95%以上，满足AAPM TG-218报告的要求。但是，修改计划在同样的标准下，部分仍在98%和95%以上。因此，在此通过标准下修改计划中引入的误差并未能检测出，说明该γ通过标准不具有针对性，本研究计划得出针对本中心特定病种诊断效能高的γ通过标准。基于PerFRACTION系统测量工具，头颈VMAT计划γ（3%/3 mm）及γ（3%/2 mm）分析结果对应的ROC下面积（AUC）分别是0.86、0.88；盆腔VMAT计划对应的AUC值分别是0.76、0.76。同样，基于ArcCHECK模体测量工具，头颈VMAT计划γ（3%/3 mm）、γ（3%/2 mm）分析结果对应的AUC值分别是0.97、0.82；盆腔VMAT计划对应的AUC值是0.98、0.86。对比ArcCHECK模体验证结果，ROC分析表明PerFRACTION基于γ（3%/3 mm）及γ（3%/2 mm）的通过标准适合作为患者质量保证结果分析的标准。此时，头颈VMAT计划对应的γ通过标准分别是98.80%、96.32%；盆腔VMAT计划对应的γ通过标准分别是99.62%、99.36%。在此标准下，PerFRACTION系统的敏感度和特异度均较高。结论：PerFRACTION系统和ArcCHECK模体验证方法同样可靠，在本文通过标准下可检测出随机误差，由于其方便、实时、敏感度高的特性，对于监测患者日常计划传输和执行情况具有较大优势。
Abstract:
Abstract: Objective To analyze the sensitivity and specificity of PerFRACTION system for volumetric modulated arc therapy (VMAT) plans executed on Trilogy accelerator, thereby obtaining the diagnostic efficacy and gamma passing criteria of PerFRACTION system for the dose verification of VMAT plans. Methods PerFRACTION is a real-time online dose verification system that could calculate the three-dimensional dose distribution through muti-leaf collimator log files, online field image data and convolution/superposition algorithm, and automatically generate dose volume histogram and gamma passing rate. Two groups of VMAT plans for different anatomical sites were randomly selected in the study, and each group of plans included original plans and modified plans with the introduction of random errors. The sensitivity and specificity of PerFRACTION system were detected on original plans and modified plans. In addition, two groups of the same plans were tested by ArcCHECK phantom, and the result was taken as a reference. Results The dosimetric analysis on original and modified plans were performed with gamma criteria of 3%/3 mm and 3%/2 mm. The gamma passing rates of original plans were above 98% and 95%, which met the requirements of AAPM-TG218 report, and some of modified plans were also above 98% and 95% under the same criteria. Therefore, the errors introduced in modified plans were not detected, indicating that the gamma criteria was not targeted. The study aimed to obtain gamma passing criteria with high diagnostic efficiency for specific diseases in our cancer center. Based on PerFRACTION system, the areas under the receiver operating characteristic curves (AUC) of head and neck VMAT plans were 0.86 and 0.88, respectively, and the corresponding AUC values of pelvic VMAT plans were 0.76 and 0.76, respectively. Similarly, based on ArcCHECK phantom, the AUC values of head and neck VMAT plans were 0.97 and 0.82 under the gamma criteria of 3%/3 mm and 3%/2 mm and the corresponding AUC values of pelvic VMAT plans were 0.98 and 0.86. Compared with the verification results of ArcCHECK phantom, ROC analysis showed that the gamma criteria (3%/3 mm, 3%/2 mm) of PerFRACTION system were suitable for the analysis of quality assurance (QA). The gamma passing rates of head and neck VMAT plans were 98.80% and 96.32%, respectively, and those of pelvic VMAT plans were 99.62% and 99.36%, respectively. Under the same criteria, PerFRACTION system had a higher sensitivity and specificity. Conclusion PerFRACTION system is reliable as ArcCHECK phantom and can be used to detect random errors. With the properties of convenience, real-time and highly sensitive, PerFRACTION system has greater advantages in monitoring daily plan transmission and plan implementation.

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[1]石锦平,石俊田,何宝贞,等.容积调强放射治疗多叶准直器质量保证方法[J].中国医学物理学杂志,2015,32(05):724.[doi:doi:10.3969/j.issn.1005-202X.2015.05.025]
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备注/Memo

备注/Memo:
【收稿日期】2020-11-09 【基金项目】国家自然科学基金青年基金（81803047） 【作者简介】闫慧芳，硕士，研究方向：肿瘤放射物理学，E-mail: 1024061308@qq.com 【通信作者】刘洪源，硕士，中级技师，研究方向：肿瘤放射物理学，E-mail: liuhongyuan1991@163.com
更新日期/Last Update: 2021-04-29