[1]刘继辉,李成海,刘雅璐,等.空化增效高强度聚焦超声治疗研究进展[J].中国医学物理学杂志,2020,37(6):758-761.[doi:DOI:10.3969/j.issn.1005-202X.2020.06.019]
　LIU Jihui,LI Chenghai,et al.Advances in research on cavitation-enhanced HIFU therapy[J].Chinese Journal of Medical Physics,2020,37(6):758-761.[doi:DOI:10.3969/j.issn.1005-202X.2020.06.019]
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空化增效高强度聚焦超声治疗研究进展()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第6期
页码:
758-761
栏目:
医学生物物理
出版日期:
2020-06-25

文章信息/Info

Title:
Advances in research on cavitation-enhanced HIFU therapy
文章编号:
1005-202X（2020）06-0758-04
作者:
刘继辉1; 2; 李成海2; 刘雅璐1; 李发琪1; 2
1.重庆医科大学生物医学工程学院超声医学工程国家重点实验室， 重庆 400016； 2.重庆市生物医学工程学重点实验室， 重庆 400016
Author(s):
LIU Jihui1;  2;  LI Chenghai2;  LIU Yalu1;  LI Faqi1;  2
1.State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China 2. Key Laboratory of Biomedical Engineering of Chongqing City, Chongqing 400016, China
关键词:
高强度聚焦超声; 空化效应; 热效应; 增效; 综述
Keywords:
Keywords: high intensity focused ultrasound cavitation effect thermal effect synergy review
分类号:
R318；TB559
DOI:
DOI:10.3969/j.issn.1005-202X.2020.06.019
文献标志码:
A
摘要:
高强度聚焦超声（HIFU）已被证实是一种安全、有效的无创实体肿瘤消融方法，但目前面临的主要问题是治疗时间相对较长、治疗效率低。在HIFU治疗中可以通过空化实现增效，通过何种方式产生空化效应，如何提高空化对热效应的增效作用一直是研究者关注的问题。本文分别从体外引入空化核、声学驱动产生空化核两个角度，综述在HIFU治疗中通过微泡造影剂、相变纳米液滴、双频HIFU、脉冲波增强热效应、调强峰值声压增强HIFU的治疗效果。 【关键词】高强度聚焦超声；空化效应；热效应；增效；综述
Abstract:
Abstract: High intensity focused ultrasound (HIFU) has been proven to be a safe and effective non-invasive solid tumor ablation method, but the main problems currently faced are relatively long duration of treatment times and low treatment efficiency. In HIFU treatment, it is possible to achieve synergy through cavitation. How to generate cavitation effects, and how to improve the synergistic effect of cavitation on thermal effects have always been a concern of researchers. From the perspective of in vitro introduction of cavitation nucleus and acoustically driven cavitation nucleus, the effects of microbubble contrast agent, phase change nanodroplets, dual-frequency HIFU, pulse-enhanced thermaleffect and intensified peak sound pressure enhance in HIFU treatment are reviewed.

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备注/Memo

备注/Memo:
【收稿日期】2019-11-11 【基金项目】国家自然科学基金（11574039） 【作者简介】刘继辉，在读硕士，研究方向：超声医学，E-mail: 495540188 @qq.com 【通信作者】李发琪，教授，博士生导师，E-mail: lifaqi70@163.com
更新日期/Last Update: 2020-07-03