[1]郭永新,王传娜,吕爽,等.2型糖尿病患者海马体脑功能连接的磁共振成像研究[J].中国医学物理学杂志,2020,37(9):1138-1142.[doi:10.3969/j.issn.1005-202X.2020.09.011]
　WANG Chuanna,LÜ Shuang,GUO Gaode,et al.Magnetic resonance imaging study of hippocampal functional connectivity in type 2 diabetes patients[J].Chinese Journal of Medical Physics,2020,37(9):1138-1142.[doi:10.3969/j.issn.1005-202X.2020.09.011]
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2型糖尿病患者海马体脑功能连接的磁共振成像研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第9期
页码:
1138-1142
栏目:
医学人工智能
出版日期:
2020-09-25

文章信息/Info

Title:
Magnetic resonance imaging study of hippocampal functional connectivity in type 2 diabetes patients
文章编号:
1005-202X（2020）09-1138-05
作者:
郭永新; 王传娜; 吕爽; 郭高德; 薛雅卓; 崔栋; 曹卫芳; 刘新凤; 焦青
1. 山东第一医科大学（山东省医学科学院）放射学院，山东泰安271016；2. 山东第一医科大学（山东省医学科学院）护理学院，山东 泰安271016；3. 山东省泰山疗养院，山东泰安271000
Author(s):
WANG Chuanna1;  LÜ Shuang1;  GUO Gaode1;  XUE Yazhuo2;  CUI Dong1;  CAO Weifang1;  LIU Xinfeng3;  GUO Yongxin1;  JIAO Qing1
1. School of Radiology, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, China 2. School of Nursing, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, China 3. Taishan Sanatorium of Shandong Province, Taian 271000, China
关键词:
2 型糖尿病; 海马体; 脑功能连接; 功能磁共振成像
Keywords:
type 2 diabetes hippocampus brain functional connectivity functional magnetic resonance imaging
分类号:
R318；R445.2
DOI:
10.3969/j.issn.1005-202X.2020.09.011
文献标志码:
A
摘要:
目的：应用功能磁共振成像技术研究2 型糖尿病（T2D）患者静息状态下海马功能连接的变化。方法：采集27 例 T2D患者和32例正常人的脑功能磁共振成像信号，选择海马的4个分区作为种子点计算功能连接，对海马与其他脑区的 功能连接强度与临床指标进行相关性分析。结果：与正常人相比，T2D患者的右前海马与梭状回、枕中回之间的功能连接 减弱；左前海马与梭状回功能连接增强；右后海马与距状回功能连接减弱；左后海马与舌回功能连接增强。结论：T2D患 者相关脑区功能连接的改变可能与视觉相关认知功能的损伤有关，这为理解T2D患者海马体的功能提供线索。
Abstract:
Objective To investigate the abnormal resting-state hippocampal functional connectivity (FC) in patients with type 2 diabetes (T2D) by functional magnetic resonance imaging technology. Methods The brain functional magnetic resonance imaging signals of 27 T2DM patients and 32 healthy controls were collected. Four sub-regions of the hippocampus were chosen as seeds for FC calculation. The correlation between clinical indices and the FC between the hippocampus and other brain regions was investigated. Results Compared with healthy controls, T2D patients showed reduced FC between the right anterior hippocampus and fusiform gyrusm, middle occipital gyrus, and between the right posterior hippocampus and calcarine. Moreover, there was increased FC in T2D patients between the left anterior hippocampus and fusiform gyrus, and between the left posterior hippocampus and lingual gyrus. Conclusion The changes of brain FC in T2D patients may play a role in vision-related cognitive impairments, which provides clues in understanding the function of hippocampus in T2D patients.

相似文献/References:

[1]张瑞萍,刘应龙,张文静,等.基于人工智能的多模态影像辅助海马体自动勾画研究[J].中国医学物理学杂志,2022,39(3):390.[doi:DOI:10.3969/j.issn.1005-202X.2022.03.021]
　ZHANG Ruiping,LIU Yinglong,ZHANG Wenjing,et al.Auto-segmentation of the hippocampus in multimodal image using artificial intelligence[J].Chinese Journal of Medical Physics,2022,39(9):390.[doi:DOI:10.3969/j.issn.1005-202X.2022.03.021]

备注/Memo

备注/Memo:
【收稿日期】2020-03-06 【基金项目】国家自然科学基金（81371531）；泰山医学院高层次课题培 育计划（2017GCC11） 【作者简介】王传娜，研究方向：生物医学工程，E-mail: 462722117@qq. com
更新日期/Last Update: 2020-09-25