[1]吴凡,郎锦义,许敬辉,等.5种铅门X轴固定技术在鼻咽癌容积旋转调强放疗中的剂量学比较[J].中国医学物理学杂志,2020,37(2):133-137.[doi:DOI:10.3969/j.issn.1005-202X.2020.02.001]
 WU Fan,LANG Jinyi,XU Jinghui,et al.Dosimetric study of 5 fixed-jaw techniques in volumetric modulated arc therapy for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2020,37(2):133-137.[doi:DOI:10.3969/j.issn.1005-202X.2020.02.001]
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5种铅门X轴固定技术在鼻咽癌容积旋转调强放疗中的剂量学比较()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第2期
页码:
133-137
栏目:
医学放射物理
出版日期:
2020-02-25

文章信息/Info

Title:
Dosimetric study of 5 fixed-jaw techniques in volumetric modulated arc therapy for nasopharyngeal carcinoma
文章编号:
1005-202X(2020)02-0133-05
作者:
吴凡1郎锦义1许敬辉1袁佳薇2康盛伟1陈亚正1吴骏翔1
1.电子科技大学医学院附属肿瘤医院四川省肿瘤医院放疗中心/放射肿瘤学四川省重点实验室, 四川 成都 610041; 2.四川省科学城医院肿瘤科, 四川 绵阳621900
Author(s):
WU Fan1 LANG Jinyi1 XU Jinghui1 YUAN Jiawei2 KANG Shengwei1 CHEN Yazheng1 WU Junxiang1
1. Sichuan Key Laboratory of Radiation Oncology/Radiation Oncology Center, Sichuan Cancer Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China; 2. Department of Oncology, Sichuan Science City Hospital, Mianyang 621900, China
关键词:
鼻咽癌铅门固定技术容积旋转调强剂量学
Keywords:
Keywords: nasopharyngeal carcinoma fixed-jaw technique volumetric modulated arc therapy dosimetry
分类号:
R815;R312
DOI:
DOI:10.3969/j.issn.1005-202X.2020.02.001
文献标志码:
A
摘要:
目的:比较鼻咽癌容积旋转调强(VMAT)计划设计中X轴方向不同铅门大小的剂量学差异,探讨鼻咽癌VMAT设计中最优的铅门固定大小。方法:在Eclipse 11.0计划系统中采用5种铅门固定方法分别对10例鼻咽癌患者设计放疗计划,比较5种计划得到的靶区和危及器官的剂量学参数以及机器跳数。采用SPSS 23.0软件对数据进行配对t检验分析。结果:5种固定铅门技术得到的靶区D95、Dmean和HI等剂量学参数均无明显差异(P>0.05),铅门在X2方向全关(FJ1)计划组的CI好于其他计划组(t=-2.97~-1.06, P<0.05);FJ1计划组得到的脊髓Dmax、左右侧腮腺、喉以及口咽的V30和Dmean等剂量学参数均优于其他计划组(t=-5.83~1.14, P<0.05),而对于脑干、耳蜗和颞叶等器官,5种固定铅门技术无明显差异(t=-0.99~2.99, P>0.05);FJ1计划组的机器跳数高于其他计划组(t=8.15~8.86, P<0.05)。结论:5种铅门固定技术均能满足临床要求,而FJ1计划组能够更好地降低危及器官照射剂量,但同时增加了机器跳数,增加了照射时间;而铅门在X2方向从半开到全关(FJ2)计划组相比于FJ1计划组对于器官的保护较差,但提高了治疗效率。
Abstract:
Abstract: Objective To compare dosimetric differences of X-axis directional fixed-jaw techniques in volumetric modulated arc therapy (VMAT) for nasopharyngeal carcinoma (NPC) for investigating the optimal fixed-jaw scheme. Methods In Eclipse 11.0 treatment planning system, 5 fixed-jaw techniques were used to design radiotherapy plans for 10 NPC patients. The differences in dosimetric parameters of target areas and organs-at-risk as well as monitor units were compared among 5 plans, and SPSS 23.0 software was used to perform paired sample t-test on the obtained data. Results There was no significant difference among 5 plans in the Dmean, D95 and homogeneity index of target areas (P>0.05), but the conformity index in FJ1 plan in which the jaw was fully closed in X2 direction was better than that in other fixed-jaw techniques (t=-2.97--1.06, P<0.05). The Dmax of spinal cord, the V30 and Dmean of parotid glands, larynx and oral cavity in FJ1 plan were lower than those in the others, with statistical significances (t=-5.83-1.14, P<0.05). No statistical significance was found in brainstem, cochlea and temporal lobes (t=-0.99-2.99, P>0.05). Moreover, FJ1 plan had the highest monitor units (t=8.15-8.86, P<0.05). Conclusion All the 5 fixed-jaw techniques can meet the clinical requirements, while FJ1 techniques can reduce organs-at-risk doses, but increase monitor units and delivery time. Compared with FJ1 techniques, FJ2 technique in which the jaw is changed from half-open to fully-closed in X2 direction has inferior organs-at-risk sparing, but improves treatment efficiency.

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备注/Memo

备注/Memo:
【收稿日期】2019-10-03 【基金项目】四川省重点研发项目(2018GZ0197);国家重点研发计划(2017YFC0113100) 【作者简介】吴凡,主管技师,研究方向:辐射物理与医学物理,E-mail:506352702@qq.com 【通信作者】吴骏翔,研究实习员,研究方向:肿瘤放射物理学,E-mail:wujx610@qq.com
更新日期/Last Update: 2020-03-03