[1]杜小梅,李明锐,吴让兵,等. 超声引导下微波消融治疗难治性甲亢临床疗效[J].中国医学物理学杂志,2019,36(6):697-700.[doi:DOI:10.3969/j.issn.1005-202X.2019.06.015]
　DU Xiaomei,LI Mingrui,WU Rangbing,et al. Therapeutic effect of ultrasound-guided microwave ablation for refractory hyperthyroidism[J].Chinese Journal of Medical Physics,2019,36(6):697-700.[doi:DOI:10.3969/j.issn.1005-202X.2019.06.015]
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 超声引导下微波消融治疗难治性甲亢临床疗效()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第6期
页码:
697-700
栏目:
医学影像物理
出版日期:
2019-06-25

文章信息/Info

Title:
 Therapeutic effect of ultrasound-guided microwave ablation for refractory hyperthyroidism
文章编号:
1005-202X（2019）06-0697-04
作者:
 杜小梅1; 李明锐1; 吴让兵1; 王华1; 宋建琼2
 1.达州市中心医院内分泌代谢科， 四川 达州 635000； 2.达州市中心医院超声科， 四川 达州 635000
Author(s):
 DU Xiaomei1;  LI Mingrui1;  WU Rangbing1;  WANG Hua1;  SONG Jianqiong2
 1. Department of Endocrinology and Metabolism, Dazhou Central Hopsital, Dazhou 635000, China; 2. Department of Ultrasound, Dazhou Central Hopsital, Dazhou 635000, China
关键词:
 ; 微波消融; 超声引导; 甲状腺功能亢进症; 碘
Keywords:
 ; Keywords: microwave ablation;  ultrasound-guided;  hyperthyroidism;  iodine
分类号:
R581.1
DOI:
DOI:10.3969/j.issn.1005-202X.2019.06.015
文献标志码:
A
摘要:
 目的：研究超声引导下微波消融治疗难治性甲状腺功能亢进症（甲亢）的临床疗效。方法：选择77例难治性甲亢患者，按照自愿原则进行分组，42例患者选择微波消融治疗，纳入观察组；35例患者选择131碘治疗，纳入对照组。检测治疗前后总三碘甲状腺激素（TT3）、游离三碘甲状腺激素（FT3）、总四碘甲状腺激素（TT4）、游离四碘甲状腺激素（FT4）、促甲状腺激素（TSH）等指标水平并评价疗效及安全性；随访24个月，记录患者甲减发生率。结果：观察组治疗后6个月时临床治愈率显著高于对照组（P<0.05）；治疗后两组患者TT3、TT4、FT3、FT4等水平显著降低（P<0.05），TSH水平升高（P<0.05），治疗前及治疗后组间比较差异均无统计学意义（P>0.05）；两组患者不良反应发生率分别为9.52%及16.67%，差异无统计学意义（P>0.05）；观察组终身性甲减发生率显著低于对照组（P<0.05）。结论：超声引导下微波消融治疗疗效与放射性碘治疗效果相当，发生终身性甲减的风险低，安全可靠。
Abstract:
 Abstract: Objective To investigate the therapeutic efficacy of ultrasound-guided microwave ablation in the treatment of refractory hyperthyroidism. Methods A total of 77 patients with refractory hyperthyroidism were enrolled in the study, and then grouped into two groups according to the voluntary principle. The patients in observation group were treated with microwave ablation (n=42), and those in control group received iodine-131 therapy (n=35). The levels of total triiodothyronine (TT3), free triiodothyronine (FT3), total tetraiodothyronine (TT4), free tetraiodothyronine (FT4) and thyroid stimulating hormone (TSH) before and after treatment were detected to evaluate the therapeutic efficacy and safety. The patients were followed-up for 24 months, and the incidence of hypothyroidism was recorded. Results The cure rate of observation group was significantly higher than that of control group at 6 months after treatment (P<0.05). After treatment, the levels of TT3, TT4, FT3 and FT4 in the two groups were significantly decreased (P<0.05), while the TSH level was increased (P<0.05). There was no significant difference between two groups before and after treatment (P>0.05). The incidences of adverse reactions in two groups were 9.52% and 16.67%, respectively, without statistical significance (P>0.05). The incidence of lifelong hypothyroidism in observation group was significantly lower than that in control group (P<0.05). Conclusion Ultrasound-guided microwave ablation which not only realizes the therapeutic effect which was similar to that of radioactive iodine treatment, but also has low risk of lifelong hypothyroidism is safe and reliable.

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备注/Memo

备注/Memo:
 【收稿日期】2018-12-11
【基金项目】四川省卫生和计划生育委员会科研课题（150054）
【作者简介】杜小梅，主任医师，主要从事糖尿病及其并发症、甲状腺疾病、骨质疏松症、痛风、肥胖等疾病的诊治，E-mail: dumeimei66@163.com
更新日期/Last Update: 2019-06-25