[1]李兰,杨伟伟,王楠. 脉冲电磁刺激对糖尿病大鼠神经病理性疼痛的影响[J].中国医学物理学杂志,2019,36(9):1082-1086.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.017]
　LI Lan,YANG Weiwei,WANG Nan. Effects of pulsed electromagnetic field stimulation on neuropathic pain in diabetic rats[J].Chinese Journal of Medical Physics,2019,36(9):1082-1086.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.017]
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 脉冲电磁刺激对糖尿病大鼠神经病理性疼痛的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第9期
页码:
1082-1086
栏目:
医学生物物理
出版日期:
2019-09-25

文章信息/Info

Title:
 Effects of pulsed electromagnetic field stimulation on neuropathic pain in diabetic rats
文章编号:
1005-202X（2019）09-1082-05
作者:
 李兰; 杨伟伟; 王楠
 西安市第九医院麻醉科， 陕西 西安710054
Author(s):
 LI Lan;  YANG Weiwei;  WANG Nan
 Department of Anesthesiology, Ninth Hospital of Xi’an, Xi’an 710054, China
关键词:
 ; 脉冲电磁刺激; 糖尿病; 神经病理性疼痛; 疼痛阈值; 神经传导速率
Keywords:
 ; Keywords: pulsed electromagnetic field stimulation;  diabetes;  neuropathic pain;  pain threshold;  nerve conduction velocity
分类号:
R741；R318
DOI:
DOI:10.3969/j.issn.1005-202X.2019.09.017
文献标志码:
A
摘要:
 目的：系统研究外源性的脉冲电磁干预法对糖尿病神经病理性疼痛（DNP）大鼠的作用效果。方法：30只成熟的雄性SD大鼠，随机等分成3组：空白对照（Control）组，DNP组以及DNP协同电磁刺激（DNP+EMF）组。DNP模型使用腹腔注射链脲佐菌素方法构建。对DNP+EMF组大鼠行外源性的全身性电磁刺激干预（脉冲波形, 频率15 Hz, 强度30 Gs），每天刺激6 h。在电磁刺激的第0、2、4、6、8周对各组大鼠进行足底机械痛阈值、足底热痛阈值、感觉神经传导速率和运动神经传导速率检测。结果：DNP+EMF组大鼠的足底机械痛阈值和热痛阈值在第4、6、8周显著高于DNP组大鼠（P<0.05）；脉冲电磁刺激从第2周开始显著提升了DNP大鼠足底的感觉神经传导速率（P<0.05），并从第4周起显著提高了DNP大鼠足底的运动神经传导速率（P<0.05）。结论：外源性的脉冲电磁刺激能够显著改善糖尿病大鼠症状，表现为痛觉敏感性和神经传导速率的提升，脉冲电磁刺激有望成为临床治疗DNP的一种新的物理治疗手段。
Abstract:
 Abstract: Objective To investigate the effects of exogenous pulsed electromagnetic field therapy on neuropathic pain in diabetic rats. Methods Thirty male adult SD rats were randomly and equally assigned into blank control (Control), DNP, and diabetic neuropathic pain (DNP) combined with electromagnetic field stimulation (DNP+EMF) groups. DNP animal model was established by the intraperitoneal injection of streptozotocin. The rats in DNP+EMF group were subjected to whole-body electromagnetic field stimulation with 6 h/day (pulse waveform, 15 Hz frequency and 30 Gs intensity). The paw mechanical pain threshold, paw thermal pain threshold, sensory nerve conduction velocity and motor nerve conduction velocity were determined at 0, 2, 4, 6 and 8 weeks after electromagnetic field stimulation. Results At 4, 6 and 8 weeks after electromagnetic field stimulation, the rats in DNP+EMF group exhibited much higher paw mechanical pain threshold and paw thermal pain threshold than those in DNP group (P<0.05). Pulse electromagnetic field stimulation significantly increased the sensory nerve conduction velocity in DNP rats from 2 weeks after electromagnetic field stimulation (P<0.05), and also significantly increased the motor nerve conduction velocity in DNP rats from 4 weeks after electromagnetic field stimulation (P<0.05). Conclusion Exogenous pulsed electromagnetic field stimulation is able to significantly improve the neuropathic pain symptoms in diabetic rats as evidenced by increased pain sensitivity and nerve conduction velocity. Pulsed electromagnetic field stimulation is expected to become a novel biophysical strategy for the treatment of DNP in clinic.

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备注/Memo

备注/Memo:
 【收稿日期】2019-04-06
【作者简介】李兰，主治医师，主要从事临床麻醉及相关科研工作，E-mail: 345113836@qq.com
【通信作者】王楠，副主任医师，从事临床麻醉与疼痛治疗以及相关科研工作，E-mail: 2358219486@qq.com
更新日期/Last Update: 2019-09-24