[1]薛娴,赵红枫,罗素明,等. 两种胶片分析方法比较多叶光栅到位精确度：多中心测量结果的初步研究[J].中国医学物理学杂志,2018,35(12):1375-1385.[doi:DOI:10.3969/j.issn.1005-202X.2018.12.003]
　XUE Xian,ZHAO Hongfeng,LUO Suming,et al. Multi-leaf collimator positioning accuracy analyzed with two film analysis methods: a preliminary multi-center measurement[J].Chinese Journal of Medical Physics,2018,35(12):1375-1385.[doi:DOI:10.3969/j.issn.1005-202X.2018.12.003]
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 两种胶片分析方法比较多叶光栅到位精确度：多中心测量结果的初步研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第12期
页码:
1375-1385
栏目:
医学放射物理
出版日期:
2018-12-24

文章信息/Info

Title:
 Multi-leaf collimator positioning accuracy analyzed with two film analysis methods: a preliminary multi-center measurement
文章编号:
1005-202X（2018）12-1375-11
作者:
 薛娴1; 赵红枫2; 罗素明1; 何志坚1; 杨春勇3; 刘冉4; 程晓军5; 孙刚涛6; 程金生1
 1.中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室， 北京 100088； 2.北京市朝阳区疾病预防控制中心， 北京 100013； 3.江苏省疾病预防控制中心， 江苏 南京 210009； 4.四川省疾病预防控制中心， 四川 成都 610031； 5.河南省职业病防治研究院， 河南 郑州 450052； 6.湖北省疾病预防控制中心， 湖北 武汉 430079
Author(s):
 XUE Xian1;  ZHAO Hongfeng2;  LUO Suming1;  HE Zhijian1;  YANG Chunyong3;  LIU Ran4;  CHENG Xiaojun5;  SUN Gangtao6;  CHENG Jinsheng1
 1. Key Laboratory of Radiation Protection and Nuclear Emergency, National Institute for Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Beijing 100088, China; 2. Beijing Chaoyang Center for Disease Prevention and Control, Beijing 100013, China; 3. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China; 4. Sichuan Center for Disease Control and Prevention, Chengdu 610031, China; 5. Henan Institute for Occupational Medicine, Zhengzhou 450052, China; 6. Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
关键词:
 ; 多叶光栅; 到位精确度; 胶片分析; 归一方法
Keywords:
 ; Keywords: multi-leaf collimator;  positioning accuracy;  film analysis;  normalization method
分类号:
R811.1；R312
DOI:
DOI:10.3969/j.issn.1005-202X.2018.12.003
文献标志码:
A
摘要:
 【摘 要】 目的：应用两种胶片分析方法分析调强治疗多叶光栅（MLC）到位精确度。 方法：选择4个省共15家医院，其中8家为Varian加速器，MLC型号均为Millenium 120；7家为Elekta加速器，MLC型号为MLCi或MLCi2。胶片放在固体水模体30 cm×30 cm，dmax点处（水下1.5 cm），SAD=100 cm，6 MV照射，250 MU（监督系数）/栅栏野，应用计划系统，在EBT3胶片上形成5条MLC栅栏野，每条栅栏野射野宽度为6 mm，5条栅栏野射野中心位置相对于中间栅栏野射野中心的位置距离分别为-6、-3、0、3、6 cm。将照射后的胶片用Epson Expression 10000XL扫描，应用Film QATM Pro软件得到栅栏野剂量曲线（profile），并用两种归一方法即截断部分光密度值区域后归一和归一到局部位置区的光密度值，从射野位置及中心位置偏差、射野宽度及偏差4个方面分析比较MLC到位精确及多中心测量结果。 结果：两种分析方法比较，5条栅栏野实际射野位置相对于计划射野位置偏差，均测得9家医院位置偏差超过国际原子能机构（IAEA）规定偏差限值±0.5 mm；分析每条栅栏野射野中心位置的偏差，分析结果均符合IAEA规定限值±0.5 mm；分析5条栅栏野宽度，并与计划设定宽度6 mm相比较，偏差均符合IAEA规定不超过±1 mm；分析射野宽度最大最小值偏差及标准差，分析结果均符合IAEA规定偏差不超过±0.75 mm，标准差不超过0.30 mm。 结论：两种胶片分析方法测量MLC叶片到位精确度，结果相近，差别较小，在此实验中两种归一方法均可被用。
Abstract:
 Abstract: Objective To assess a picket fence test using two methods of film analysis for verifying the positioning accuracy of multi-leaf collimator (MLC). Methods Among selected 15 hospitals in 4 provinces, 8 of them applied Varian accelerator using MLC (Millenium 120), and the other 7 adopted Elekta accelerator using MLC (MLCi or MLCi2). The film was placed at dmax (1.5 cm underwater) in a solid water phantom of 30 cm×30 cm, with a source axis distance of 100 cm. The film received an irradiation of 6 MV and 250 MU per MLC strip. Five MLC strips were generated on EBT3 film, and the width of each strip was 6 mm. The centers of 5 MLC strips were located at -6, -3, 0, 3 and 6 cm from the center of the middle MLC strip. The irradiated films were scanned with Epson Expression 10000XL scanner, and the dose curve of irradiation field (profile) was analyzed and calculated by Film QATM Pro software. Two normalization methods, namely truncating at the smallest local min and max values and normalizing to 0 and 1 (TLN) and equalizing all local min and max values to 0 and 1 (ELN), were used to analyze the field location and deviation of the center, field width and deviation for comparing the MLC positioning accuracy and multi-center measured results. Results The deviation between measured field positions of 5 strips and planned strip positions in 9 hospitals exceeded ±0.5 mm which was recommended by International Atomic Energy Agency (IAEA). The deviation of the center of each irradiation field was up to standard which is ±0.5 mm recommended by IAEA. The deviation between the width of 5 fence fields and planned width (6 mm) was less than ±1 mm, conforming to IAEA standard. Moreover, the deviation and standard deviation of maximum-minimum widths met IAEA standards (no more than 0.75 mm and 0.30 mm, respectively). Conclusion The MLC positioning accuracy measured by two normalization methods of film analysis is similar. Both TLN and ELN are reliable in the verification of MLC positioning accuracy.

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备注/Memo

备注/Memo:
 【收稿日期】2018-07-11
【基金项目】IAEA资助项目（17821/CRP）
【作者简介】薛娴，助理研究员，主要从事放射治疗质控研究，E-mail: xianxue668@163.com；赵红枫，主管技师，主要从事放射防护工作，E-mail: 13521391006@139.com
【通信作者】程金生，E-mail: chengjinsheng@nirp.chinacdc.cn
更新日期/Last Update: 2018-12-24