[1]李玉成,陈维军,单国平,等. 摆位误差对立体定向放射治疗计划剂量学验证的影响[J].中国医学物理学杂志,2018,35(8):869-873.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.001]
　LI Yucheng,CHEN Weijun,et al. Effects of setup errors on dosimetric verification of stereotactic body radiotherapy plan[J].Chinese Journal of Medical Physics,2018,35(8):869-873.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.001]
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 摆位误差对立体定向放射治疗计划剂量学验证的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第8期
页码:
869-873
栏目:
医学放射物理
出版日期:
2018-08-20

文章信息/Info

Title:
 Effects of setup errors on dosimetric verification of stereotactic body radiotherapy plan
文章编号:
1005-202X（2018）08-0869-05
作者:
 李玉成1; 2; 陈维军2; 单国平3; 赵凯3; 史国栋3; 邵凯南3; 李浦3; 杨一威3; 陈祥1; 程品晶1
 1.南华大学核科学技术学院， 湖南 衡阳 421001； 2.浙江省人民医院放疗科， 浙江 杭州 311400； 3.浙江省肿瘤医院放射物理室， 浙江 杭州 311400
Author(s):
 LI Yucheng1;  2;  CHEN Weijun2;  SHAN Guoping3;  ZHAO Kai3;  SHI Guodong3;  SHAO Kainan3;  LI Pu3;  YANG Yiwei3;  CHEN Xiang1;  CHENG Pinjing1
 1. Shool of Nuclear Science and Technology, University of South China, Hengyang 421001, China; 2. Department of Radiotherapy, Zhejiang Provincial People’s Hospital, Hangzhou 311400, China; 3. Department of Radiation Physics, Zhejiang Cancer Hospital, Hangzhou 311400, China
关键词:
 ; 立体定向放射治疗; 摆位误差; 剂量验证; γ通过率; 肺癌
Keywords:
 ; Keywords: stereotactic body radiotherapy;  setup error;  dosimetric verification;  gamma passing rate;  lung cancer
分类号:
R730.55
DOI:
DOI:10.3969/j.issn.1005-202X.2018.08.001
文献标志码:
A
摘要:
 目的：分析立体定向放射治疗（SBRT）患者中摆位误差对剂量学验证结果的影响。 方法：分别对14例肺癌患者进行SBRT计划设计，并将计划移植到Delta4剂量验证模体中进行剂量计算，在Varian Trilogy加速器上进行照射，通过移动治疗床模拟患者左（+X）、右（-X）、头（+Y）、脚（-Y）、腹（+Z）、背（-Z）方向上1、3、5 mm的摆位误差，对这6个方向γ通过率的相关性进行分析，从而在γ（3%/3 mm, 2%/2 mm）两个标准情况下验证摆位误差对剂量验证通过率的影响。 结果：γ（2%/2 mm）参数下仅摆位误差为1 mm时的右方向和脚方向与原计划相比差异无统计学意义（P>0.05）；γ（3%/3 mm）参数下摆位误差为1 mm时所有方向与原计划相比差异均无统计学意义（P>0.05）。当摆位误差为1 mm时各方向的两个标准的γ通过率均＞90%；当摆位误差为3 mm时，γ（3%/3 mm）的右、脚、腹和背方向的γ通过率＞90%，其它方向以及γ（2%/2 mm）标准下的γ通过率均＜90%；当摆位误差为5 mm时，各方向的两个标准的γ通过率均＜90%，头方向γ（2%/2 mm）通过率降为（35.29±8.40）%。 结论：摆位误差对于SBRT计划的剂量学验证有较大的影响，标准越严格，摆位误差对验证通过率的影响越明显。
Abstract:
 Abstract: Objective To analyze the effects of setup errors on dosimetric verification of stereotactic body radiotherapy (SBRT) in patients with lung cancer. Methods SBRT plans were designed for 14 patients with lung cancer, and then transplanted to Delta4 phantom for dose calculation. The irradiation was implemented on Varian Trilogy linear accelerator. The setup errors were simulated by moving the treatment couch to the left (+X), right (-X), head (+Y), foot (-Y), ventral (+Z), back (-Z) by 1, 3 and 5 mm. The relationships of gamma passing rate in the 6 directions were analyzed for verifying the effects of setup errors on dose verification under different gamma criteria (3%/3 mm, 2%/2 mm). Results Only when the setup error was 1 mm, the differences in the right and foot directions had no statistical significance as compared with original plan under the gamma criterion of 2%/2 mm (P>0.05), and no statistical significance was found in all directions under the gamma criterion of 3%/3 mm (P>0.05). When the setup error was 1 mm, the gamma passing rates were all greater than 90% under the two gamma criteria (3%/3 mm, 2%/2 mm). When the setup error was 3 mm, only the gamma passing rates in the direction of right, foot, ventral and back were greater than 90%. When the setup error was 5 mm, the gamma passing rates were all less than 90% under the two gamma criteria (3%/3 mm, 2%/2 mm), and the total passing rate of head direction were decreased to (35.29±8.40)%. Conclusion Setup error has great effects on the dosimetric verification of SBRT plan. The finer the gamma criteria are, the more obvious the effects of setup error on the gamma passing rate are.

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备注/Memo

备注/Memo:
 【收稿日期】2018-02-27
【基金项目】国家重点研发计划（2017YFC0113201）；浙江省医药卫生科技计划项目（2017PY014）
【作者简介】李玉成，硕士研究生，研究方向：放射物理治疗，E-mail: liyucheng0402@163.com
【通信作者】程品晶，副教授，研究方向：放射物理治疗，E-mail: nhuchpj@aliyun.com
更新日期/Last Update: 2018-07-26