[1]王伟茜,刘新凤,曹卫芳,等.2型糖尿病磁共振成像静息态低频振幅变化及其与认知受损的相关性[J].中国医学物理学杂志,2018,35(5):543-548.[doi:DOI:10.3969/j.issn.1005-202X.2018.05.009]
　WANG Weiqian,LIU Xinfeng,CAO Weifang,et al.Altered fractional amplitude of low-frequency fluctuation of fMRI signals and its correlation with cognitive impairment in type 2 diabetes mellitus patients[J].Chinese Journal of Medical Physics,2018,35(5):543-548.[doi:DOI:10.3969/j.issn.1005-202X.2018.05.009]
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2型糖尿病磁共振成像静息态低频振幅变化及其与认知受损的相关性()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第5期
页码:
543-548
栏目:
医学影像物理
出版日期:
2018-05-22

文章信息/Info

Title:
Altered fractional amplitude of low-frequency fluctuation of fMRI signals and its correlation with cognitive impairment in type 2 diabetes mellitus patients
文章编号:
1005-202X（2018）05-0543-06
作者:
 王伟茜1; 刘新凤2; 曹卫芳1; 薛雅卓3; 郭艳成3; 卢爱霞3; 崔栋1; 郭永新1; 焦青1
 1.泰山医学院放射学院， 山东 泰安 271016； 2.泰山疗养院， 山东 泰安 271000； 3.泰山医学院护理学院， 山东 泰安 271016
Author(s):
 WANG Weiqian1;  LIU Xinfeng2;  CAO Weifang1;  XUE Yazhuo3;  GUO Yancheng3;  LU Aixia3;  CUI Dong1;  GUO Yongxin1;  JIAO Qing1
 1. School of Radiology, Taishan Medical University, Tai’an 271016, China; 2. Taishan Sanatorium of Shandong Province, Tai’an 271000, China; 3. School of Nursing, Taishan Medical University, Tai’an 271016, China
关键词:
 ; 2型糖尿病; 功能磁共振成像; 分数低频振幅; 认知受损
Keywords:
 ; type 2 diabetes mellitus;  functional magnetic resonance imaging;  fractional amplitude of low-frequency fluctuation;  cognitive impairment
分类号:
R445.2
DOI:
DOI:10.3969/j.issn.1005-202X.2018.05.009
文献标志码:
A
摘要:
目的：应用功能磁共振成像技术及认知功能测试探讨2型糖尿病（T2DM）静息态脑功能改变。 方法：采集28例T2DM患者及28例正常中老年人的静息态功能磁共振信号和认知功能指标，计算分数低频振幅（fALFF），比较两组被试的fALFF差异，并分析其与行为学指标的相关性。 结果：与健康成年人相比，T2DM患者的fALFF在右侧小脑、右侧背外侧额上回显著增加，在左侧颞中回、左侧距状裂、右侧颞中回、右侧辅助运动区显著降低。右侧颞中回与连线测试A的结果呈负相关。 结论：结果表明T2DM患者具有异常的神经自发神经活动，为糖尿病患者降低的认知功能提供初步的影像学证据。
Abstract:
 Objective To investigate abnormal resting-state brain activities in patients with type 2 diabetes mellitus (T2DM) by functional magnetic resonance imaging (fMRI) technology and cognitive function tests. Methods The fMRI signals and cognitive functions of 28 T2DM patients and 28 healthy controls were collected. Fractional amplitudes of low-frequency fluctuation (fALFF) of fMRI signals were calculated, and differences of fALFF between the two groups were compared. Correlations between results of fALFF and cognitive tests were analyzed. Results Compared with healthy controls, T2DM patients developed significantly increased fALFF in the right cerebellum and the right dorsolateral superior frontal gyrus, and obviously decreased fALFF in the left middle temporal gyrus, the left calcarine, the right middle temporal gyrus and the right supplementary motor area. fALFF in the right middle temporal was negatively correlated to the results of trail making test-A. Conclusion Abnormal spontaneous neural activities are observed in T2DM patients, which may provide preliminary imaging evidence for cognitive impairment in diabetic patients.

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备注/Memo

备注/Memo:
 【收稿日期】2017-11-25
【基金项目】国家自然科学基金（81371531）；山东省高校科技计划项目（J14LK55）；山东省医药卫生科技发展计划项目（2016WS0603, 2016WS0613）；泰安市科技发展计划项目；（2015NS2073, 2015NS2113）
【作者简介】王伟茜，研究方向：医学影像技术，E-mail: 1084348146@qq.com
【通信作者】焦青，博士，教授，研究方向：生物医学信号处理、磁共振成像技术，E-mail: bingbao17@163.com
更新日期/Last Update: 2018-05-22