[1]杨丹,刘丽,刘双双,等.激光散斑对比成像技术在脑血流研究中的应用[J].中国医学物理学杂志,2026,43(4):455-461.[doi:DOI:10.3969/j.issn.1005-202X.2026.04.005]
　YANG Dan,LIU Li,LIU Shuangshuang,et al.Applications of laser speckle contrast imaging in cerebral blood flow research[J].Chinese Journal of Medical Physics,2026,43(4):455-461.[doi:DOI:10.3969/j.issn.1005-202X.2026.04.005]
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激光散斑对比成像技术在脑血流研究中的应用()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
43卷
期数:
2026年第4期
页码:
455-461
栏目:
医学影像物理
出版日期:
2026-04-28

文章信息/Info

Title:
Applications of laser speckle contrast imaging in cerebral blood flow research
文章编号:
1005-202X（2026）04-0455-07
作者:
杨丹; 刘丽; 刘双双; 张诚程; 王丽妍; 方三华
浙江大学医学院公共技术平台， 浙江 杭州 310058
Author(s):
YANG Dan;  LIU Li;  LIU Shuangshuang;  ZHANG Chengcheng;  WANG Liyan;  FANG Sanhua
Core Facilities of School of Medicine, Zhejiang University, Hangzhou 310058, China
关键词:
激光散斑对比成像; 脑血流; 高时空分辨率; 脑缺血; 脑肿瘤; 综述
Keywords:
Keywords: laser speckle contrast imaging cerebral blood flow high spatiotemporal resolution cerebral ischemia brain tumor review
分类号:
R318.51； R743
DOI:
DOI:10.3969/j.issn.1005-202X.2026.04.005
文献标志码:
A
摘要:
激光散斑对比成像（LSCI）作为新兴光学成像技术，凭借高时空分辨率、无标记、操作简便等优势，已成为脑血流（CBF）监测领域核心工具。本文系统综述其基本原理、技术改进、应用进展及挑战，简述散斑形成与对比分析核心原理，涵盖空间对比分析、时间对比分析等经典分析方法；聚焦分辨率提升、定量优化、运动伪影抑制及光学清除等关键技术突破；全面总结其在正常脑生理、脑缺血、脑肿瘤等场景的监测成果与临床转化探索；剖析成像深度拓展、定量方法标准化等核心挑战，结合最新研究细化技术瓶颈，展望多模态融合等发展趋势并明确实施路径。本综述可为生物医学与光学工程领域研究者提供全面技术参考，助力LSCI在脑血流监测及相关疾病研究中的推广与深化应用。
Abstract:
Abstract: Laser speckle contrast imaging, as an emerging optical imaging technology, has become a core tool in cerebral blood flow monitoring owing to its advantages including high spatiotemporal resolution, label-free detection, and simple operation. A systematical review on its basic principles, technical improvements, application progress, and challenges is provided. It briefly describes the core principles of speckle formation and contrast analysis, encompassing classical analytical methods such as spatial laser speckle contrast analysis and temporal laser speckle contrast analysis, with a special focus on key technical breakthroughs in resolution enhancement, quantitative optimization, motion artifact suppression, and optical clearing. Furthermore, the monitoring achievements and clinical translational exploration in scenarios such as normal brain physiology, cerebral ischemia, and brain tumors are comprehensively summarized, and the core challenges including imaging depth extension and quantitative method standardization are analyzed. Based on recent research, technical bottlenecks are further refined. Finally, the development trends including multimodal fusion are prospected, and the corresponding implementation paths are clarified. This review provides comprehensive technical references for researchers in biomedicine and optical engineering, and facilitates the widespread and in-depth application of laser speckle contrast imaging in cerebral blood flow monitoring and related disease research.

相似文献/References:

[1]李尚彬,金 贵,秦明新,等.基于对称抵消技术的磁感应相位移非接触脑血流搏动测量[J].中国医学物理学杂志,2015,32(01):72.[doi:10.3969/j.issn.1005-202X.2015.01.018]
[2]彭斌,李根,秦明新,等.基于磁感应相移技术测量脑血流实验研究[J].中国医学物理学杂志,2015,32(05):643.[doi:doi:10.3969/j.issn.1005-202X.2015.05.007]

备注/Memo

备注/Memo:
【收稿日期】2026-01-20 【基金项目】国家自然科学基金（82103683）；浙江省科技厅基础公益研究计划（分析测试）（LGC22H310001）；浙江省教育厅项目（Y202250110）；浙江大学实验技术研究项目（SYBJS20221） 【作者简介】杨丹，硕士，实验师，主要从事大型成像仪器设备共享管理和光学显微成像技术研究，E-mail: 0919304@zju.edu.cn 【通信作者】方三华，博士，高级实验师，研究方向：光学显微成像技术在神经科学中应用，E-mail: fshfbzxhq@zju.edu.cn
更新日期/Last Update: 2026-04-28