[1]钟铭,蔡可超,王慧亮.FLASH放射治疗的图像引导与触发式自适应放疗[J].中国医学物理学杂志,2026,43(9):1215-1224.[doi:DOI:10.3969/j.issn.1005-202X.2026.09.009]
　ZHONG Ming,CAI Kechao,WANG Huiliang.Image-guided and FLASH triggered adaptive radiotherapy[J].Chinese Journal of Medical Physics,2026,43(9):1215-1224.[doi:DOI:10.3969/j.issn.1005-202X.2026.09.009]
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FLASH放射治疗的图像引导与触发式自适应放疗()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
43卷
期数:
2026年第9期
页码:
1215-1224
栏目:
医学放射物理
出版日期:
2026-09-30

文章信息/Info

Title:
Image-guided and FLASH triggered adaptive radiotherapy
文章编号:
1005-202X（2026）09-1215-10
作者:
钟铭1; 蔡可超2; 王慧亮1
1.中广核医疗科技（绵阳）有限公司， 北京 102206；2.中广核金沃科技有限公司， 广东 深圳 518100
Author(s):
ZHONG Ming1;  CAI Kechao2;  WANG Huiliang1
1. CGN Medical Technology (Mianyang) Co., Ltd., Beijing 102206, China 2. CGN Jinwo Technology Co., Ltd., Shenzhen 518100, China
关键词:
FLASH放射治疗; 图像引导放射治疗; 触发式自适应放疗; 综述
Keywords:
Keywords: FLASH radiotherapy image-guided radiotherapy triggered adaptive radiotherapy review
分类号:
R815
DOI:
DOI:10.3969/j.issn.1005-202X.2026.09.009
文献标志码:
A
摘要:
FLASH放射治疗是一种采用超高剂量率、在极短时间内完成剂量递送的新型放射治疗模式，近年来在多种射线类型中显示出潜在的正常组织保护效应。随着FLASH放疗逐步向临床应用推进，其超短照射时间对图像引导与自适应放射治疗技术提出新的医学物理挑战。传统基于摆位阶段持续几何校正和在线优化的技术路径在FLASH条件下面临显著的时间学与系统复杂性限制。从医学物理与系统工程角度，对FLASH放射治疗中图像引导与自适应相关技术的研究进展进行综述，重点分析超短照射时间对图像引导功能边界的影响，总结光子/电子FLASH与质子FLASH在体验证与剂量引导方面的主要技术路线，并比较不同射线类型在可观测物理量与验证策略上的差异。同时，对以在体验证为基础的触发式自适应放疗（Triggered ART）在FLASH放疗中的可行性及其质量保证要求进行讨论。本文在时间尺度定量分析、在体验证技术临床转化对比以及Triggered ART范式定义方面提供新的分析视角，可为相关技术研究与工程实现提供参考。
Abstract:
Abstract: FLASH radiotherapy is an emerging radiotherapy modality that delivers radiation at ultra-high dose rates within an extremely short timeframe, exhibiting potential normal tissue sparing effects across various radiation types in recent years. As FLASH radiotherapy progresses toward clinical application, its ultra-short irradiation duration poses new medical physics challenges for image-guided and adaptive radiotherapy technologies. Traditional approaches based on continuous geometric correction in patient positioning and online optimization encounter significant limitations in both temporal and systemic complexity under FLASH conditions. This review summarizes research advances in image guidance and adaptive techniques for FLASH radiotherapy from the perspectives of medical physics and systems engineering. It highlights the effects of ultra-short irradiation durations on the functional boundaries of image guidance, summarizes key technical approaches for in vivo verification and dose guidance in photon/electron FLASH and proton FLASH, and compares differences in observable physical quantities and verification strategies across various radiation types. Additionally, the feasibility of triggered adaptive radiotherapy based on in vivo verification in FLASH radiotherapy and its quality assurance requirements are discussed. This review provides novel analytical perspectives for quantitative temporal analysis, clinical translation of in vivo verification technologies, and definition of a triggered adaptive paradigm, severing as references for related technological research and engineering implementation.

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备注/Memo

备注/Memo:
【收稿日期】2026-04-26 【作者简介】钟铭，研究方向：放射治疗设备系统设计，E-mail: zhongming3@cgnpc.com.cn 【通信作者】王慧亮，研究方向：放射治疗设备系统设计，E-mail: myching@163.com
更新日期/Last Update: 2026-09-30