[1]王美娇,刘嘉城,姚凯宁,等.用于海马体保护预防性全脑照射的Edge-VMAT、Halcyon-VMAT和HyperArc计划的剂量学对比[J].中国医学物理学杂志,2026,43(2):141-147.[doi:DOI:10.3969/j.issn.1005-202X.2026.02.001]
　WANG Meijiao,LIU Jiacheng,YAO Kaining,et al.Dosimetric comparison of Edge-VMAT, Halcyon-VMAT, and HyperArc plans for hippocampal-sparing prophylactic cranial irradiation[J].Chinese Journal of Medical Physics,2026,43(2):141-147.[doi:DOI:10.3969/j.issn.1005-202X.2026.02.001]
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用于海马体保护预防性全脑照射的Edge-VMAT、Halcyon-VMAT和HyperArc计划的剂量学对比()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
43卷
期数:
2026年第2期
页码:
141-147
栏目:
医学放射物理
出版日期:
2026-02-27

文章信息/Info

Title:
Dosimetric comparison of Edge-VMAT, Halcyon-VMAT, and HyperArc plans for hippocampal-sparing prophylactic cranial irradiation
文章编号:
1005-202X（2026）02-0141-07
作者:
王美娇; 刘嘉城; 姚凯宁; 蒲亦晨; 张健; 刘卓伦; 杜乙
北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科/恶性肿瘤发病机制及转化研究教育部重点实验室， 北京 100142
Author(s):
WANG Meijiao;  LIU Jiacheng;  YAO Kaining;  PU Yichen;  ZHANG Jian;  LIU Zhuolun;  DU Yi
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing)/Department of Radiotherapy, Peking University Cancer Hospital & Institute, Beijing 100142, China
关键词:
HyperArc; Halcyon; 海马体保护; 预防性全脑放疗; 容积旋转调强放疗
Keywords:
Keywords: HyperArc Halcyon hippocampal-sparing prophylactic cranial irradiation volumetric-modulated arc?herapy
分类号:
R318；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2026.02.001
文献标志码:
A
摘要:
目的：通过量化3种放疗计划方法之间的剂量学差异，研究多维度的剂量学分析和治疗效率评估，旨在建立标准化、高质量的海马体保护预防性全脑照射（HS-PCI）临床计划设计模板，从而提升计划设计质量并优化临床治疗效率。方法：20例HS-PCI患者，每例患者均设计3种放疗计划，比较3种计划（Edge-VMAT、Halcyon-VMAT和HyperArc）的靶区剂量、危及器官剂量和机器跳数的差异。结果：HyperArc计划的PTV D98%和V95%最高，显著优于Edge-VMAT和Halcyon-VMAT计划（P<0.05）。HyperArc计划PTV Dmean最高，但3种计划间差异无统计学意义（P>0.05）。Edge-VMAT计划PTV Dmax剂量最低，但组间差异没有统计学意义（P>0.05）。PTV Dmin结果显示Halcyon-VMAT计划剂量最高，与Edge-VMAT和HyperArc计划均有统计学意义（P<0.05）。PTV D2%结果显示Edge-VMAT计划剂量最低，与Halcyon-VMAT和HyperArc计划均有统计学意义（P<0.05）。计划质量评估结果显示，HyperArc计划的适形度指数最高，均匀性指数最低，均显著优于其他两种计划（P<0.05）。3种放疗计划的海马体Dmax中位数均为17 Gy，HyperArc与Halcyon-VMAT计划间差异有统计学意义（P<0.05）。对于海马体Dmean和Dmin，HyperArc计划剂量最低，Edge-VMAT与Halcyon-VMAT、Halcyon-VMAT与HyperArc组间均有统计学意义（P<0.05）。左侧和右侧眼晶体、左侧视神经和视交叉的Dmax，以及左侧和右侧眼球的Dmean在3种放疗计划间均有统计学意义（P<0.05）。结论：HyperArc计划靶区具有更优的适形度和覆盖率，同时显著降低危及器官的剂量，可作为HS-PCI治疗的有效方案。
Abstract:
Abstract: Objective To establish a standardized and high-quality planning template for hippocampal-sparing prophylactic cranial irradiation (HS-PCI) by quantifying the dosimetric differences among 3 treatment planning methods and conducting multidimensional dosimetric analysis and treatment efficiency evaluation, thereby improving the planning quality and clinical efficiency. Methods Twenty HS-PCI patients were enrolled, with 3 treatment plans, namely Edge-VMAT, Halcyon-VMAT, and HyperArc, designed for each patient. The differences in target dose, organs-at-risk dose, and machine units were compared among the 3 plans. Results The HyperArc plans exhibited significantly higher PTV D98% and V95 % than the Edge-VMAT plans and the Halcyon-VMAT plans (P<0.05). Although the HyperArc plans yielded the highest PTV Dmean, the differences among the 3 plans were trivial (P>0.05) and the lowest PTV Dmax was observed in the Edge-VMAT plans, but the differences across the 3 plans were also statistically insignificant (P>0.05). For PTV Dmin, the Halcyon-VMAT plans had the highest dose, with significant differences as compared with the other two plans (P<0.05). The PTV D2% in the Edge-VMAT plans was significantly lower than those in the other two plans (P<0.05). Plan quality evaluation showed that HyperArc plans achieved the highest conformity index and the lowest homogeneity index, both of which were significantly superior to those of the other two plans (P<0.05). The median hippocampal Dmax was 17 Gy for all 3 radiotherapy plans, with a statistically significant difference observed between the HyperArc plans and Halcyon-VMAT plans (P<0.05). For hippocampal Dmean and Dmin, the HyperArc plans had the lowest dose, and statistically significant differences were noted between the Edge-VMAT plans and Halcyon-VMAT plans, as well as between the Halcyon-VMAT plans and HyperArc plans (P<0.05). There were statistically significant differences among the 3 techniques in the Dmax of the left and right lens, left optic nerve and optic chiasm, as well as the Dmean of the left and right eyeballs (P<0.05). Conclusion HyperArc plan can be served as an effective treatment option for HS-PCI for it achieves superior target conformity and coverage while significantly reducing the dose to organs-at-risk.

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备注/Memo

备注/Memo:
【收稿日期】2025-09-13 【基金项目】国家自然科学基金（12375335）；北京市自然科学基金（25JL001）；内蒙古自治区自然科学基金（2025MS01001） 【作者简介】王美娇，硕士研究生，工程师，研究方向：放射医学，E-mail: 18301663962@163.com 【通信作者】杜乙，博士，高级工程师，研究方向：医学物理，E-mail: yidu_rt@163.com
更新日期/Last Update: 2026-01-27