面向临床医学应用的新型 X 射线相位衬度成像方法-《中国医学物理学杂志》

文章信息/Info

Title:: A novel X-ray phase contrast imaging approach for clinical application

作者:: 孙程成 1; 周陈鹏 2; 3; 王研 2; 3; 张凯 2; 3; 1. 国家电网公司北京电力医院耳鼻咽喉头颈外科,北京 100073;2. 中国科学院高能物理研究所北京同步辐射装置 X 射线光学与技术实验室,北京 100049;3. 中国科学院大学核科学与技术学院,北京 100049

Author(s):: SUN Chengcheng1; ZHOU Chenpeng2; 3; WANG Yan2; 3; ZHANG Kai2; 3; 1. Department of Otolaryngology Head and Neck Surgery, Beijing Electric Power Hospital, State Grid Corporation of China, Beijing 100073, China; 2. Beijing Synchrotron Radiation Facility, X-ray Optics and Technology Laboratory, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; 3. School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China

Keywords:: X-ray imaging; phase contrast; information extraction; biomedical imaging

摘要:: 基于对小孔成像理论的 X 射线相位衬度成像研究,提出一种基于吸收网格扫描的 X 射线相位衬度成像的新方法, 可以有效获取弱吸收生物样品的吸收信息、折射信息和散射信息。实验结果表明,与传统 X 射线光栅相位衬度成像比较, 该方法具有成像装置简单易于实现且对光源要求低的优势,可更好地与实验室 X 射线源或同步辐射白光光源相结合,从而为现有 X 射线相位衬度成像技术在大尺寸人体器官的临床医学成像研究工作的开展提供新的研究手段。

Abstract:: A new X-ray phase contrast imaging method utilizing scanning absorption grid technology is proposed based on the study of X-ray phase contrast imaging with pinhole imaging principle. The method can effectively capture absorption, refraction, and scattering information of weakly absorbing biological samples. Experimental results show that the proposed method offers several advantages over traditional X-ray grating phase contrast imaging, including a simple imaging device, minimal X-ray source requirements, and enhanced compatibility with laboratory X-ray source or synchrotron radiation white beam. Consequently, it provides a new research mean for advancing current X-ray phase contrast imaging technology in clinical imaging research of large human organs.