基于太赫兹时域光谱技术的大鼠皮肤瘢痕无创检测-《中国医学物理学杂志》

文章信息/Info

Title:: Non-invasive detection of rat skin scars using terahertz time-domain spectroscopy technology

作者:: 木热孜亚?明江1; 耿少辉1; 管一玮2; 沈春丽3; 温景琦4; 黄光瑞1; 1.北京中医药大学生命科学院，北京 102446； 2.北京中医药大学中药学院，北京 102488； 3.北京中医药大学针灸推拿学院，北京 100029； 4.北京中医药大学中医学院，北京 100029

Author(s):: MUREZIYA Yimingjiang1; GENG Shaohui1; GUAN Yiwei2; SHEN Chunli3; WEN Jingqi4; HUANG Guangrui1; 1. School of Life Sciences, Beijing University of Chinese Medicine, Beijing 102446, China 2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China 3. School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China 4. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

Keywords:: Keywords: skin scar terahertz time-domain spectroscopy principal component analysis

摘要:: 目的：利用太赫兹时域光谱技术，探索大鼠皮肤瘢痕与正常皮肤的太赫兹信号特征差异，为皮肤瘢痕的病理检测提供新型无创检测技术。方法：制备全层皮肤缺损大鼠模型，利用反射式太赫兹时域光谱系统获得大鼠正常皮肤组织以及瘢痕组织的太赫兹信号图。结果：大鼠正常皮肤太赫兹信号可见两个明显的反射时域信号峰，且不同反射点反射峰信号特征较为规律；大鼠皮肤瘢痕部位太赫兹信号也具有两个明显的反射时域信号峰，但最高峰峰值相比正常皮肤太赫兹信号低。此外，通过主成分分析法发现瘢痕部位信号聚集在一起，正常皮肤信号聚集在一起。不同部位的太赫兹信号差异有统计学意义（P<0.05）。结论：太赫兹时域光谱技术可应用于皮肤瘢痕的无创检测，在生物医学领域具有很好的应用前景。

Abstract:: Abstract: Objective To explore the difference in terahertz signal characteristics between rat skin scar and normal skin using terahertz time-domain spectroscopy technology, thereby providing a novel non-invasive detection technique for the pathological examination of skin scars. Methods A rat model of whole-layer skin defect was prepared, and a reflectance terahertz time-domain spectroscopy system was used to obtain the terahertz signal maps of normal skin and scarred area. Results The terahertz signals of normal skin showed two obvious reflection time-domain signal peaks, and the characteristics of the reflection peaks at different reflection points were relatively regular. The terahertz signals of skin scar also had two obvious reflection time-domain signal peaks, but the highest peak was lower than that of normal skin. In addition, principal component analysis revealed that skin scar signals and normal skin signals were clustered together separately. The terahertz signal at different sites differed significantly (P<0.05). Conclusion Terahertz time-domain spectroscopy technology can be applied to the non-invasive detection of skin scarring, exhibiting a good application prospect in biomedicine.