[1]吴晋,李仕军,王誉鑫,等.SPEEDO：一款快速准确的碳离子蒙特卡罗剂量计算程序[J].中国医学物理学杂志,2024,41(10):1189-1198.[doi:DOI:10.3969/j.issn.1005-202X.2024.10.001]
　WU Jin,LI Shijun,WANG Yuxin,et al.SPEEDO: a rapid and accurate Monte Carlo dose calculation program for carbon ion therapy[J].Chinese Journal of Medical Physics,2024,41(10):1189-1198.[doi:DOI:10.3969/j.issn.1005-202X.2024.10.001]
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SPEEDO：一款快速准确的碳离子蒙特卡罗剂量计算程序()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
41卷
期数:
2024年第10期
页码:
1189-1198
栏目:
医学放射物理
出版日期:
2024-10-25

文章信息/Info

Title:
SPEEDO: a rapid and accurate Monte Carlo dose calculation program for carbon ion therapy
文章编号:
1005-202X（2024）10-1189-10
作者:
吴晋1; 李仕军1; 王誉鑫1; 常艳奎1; 裴曦2; 陈志1; 陈卫强3; 李强3; 徐榭1; 4
1.中国科学技术大学核科学技术学院， 安徽 合肥 230026； 2.安徽慧软科技有限公司， 安徽 合肥 238000； 3.中国科学院近代物理研究所， 甘肃 兰州 730099； 4.中国科学技术大学附属第一医院放疗科， 安徽 合肥 230026
Author(s):
WU Jin1;  LI Shijun1;  WANG Yuxin1;  CHANG Yankui1;  PEI Xi2;  CHEN Zhi1;  CHEN Weiqiang3;  LI Qiang3;  XU Xie George1;  4
1. School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026, China 2. Anhui Wisdom Technology Company Limited, Hefei 238000, China 3. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730099, China 4. Department of Radiotherapy, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230026, China
关键词:
碳离子治疗; 蒙特卡罗; 电磁过程; 核相互作用
Keywords:
Keywords: carbon ion therapy Monte Carlo electromagnetic process nuclear interaction
分类号:
R318；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2024.10.001
文献标志码:
A
摘要:
目的：开发一款用于碳离子治疗的快速准确的蒙特卡罗程序SPEEDO。方法：对于电磁过程，采用连续慢化近似的II类浓缩历史模拟方案，模拟能量歧离、射程歧离、多重散射和电离过程。对于核相互作用，本研究考虑5种靶核：氢、碳、氮、氧和钙。产生的次级带电粒子遵循同样的浓缩历史框架。本研究模拟碳离子在4种材料（水、软组织、肺和骨头）中的输运过程，并将计算的剂量结果与放射治疗物理专用蒙特卡罗模拟软件TOPAS进行对比验证，最后与在武威重离子治疗中心医用重离子加速器示范装置（HIMM-WW）上测得的水箱剂量进行对比。结果：SPEEDO的模拟结果与TOPAS具有良好的一致性。对于每种材料在物理剂量大于其体素最大剂量点10%的体素区域，两者的相对最大剂量平均误差均小于2%。在治疗能量为400 MeV/u时，SPEEDO的计算时间（13.8 min）明显小于TOPAS的计算时间（105.0 min）。SPEEDO的计算结果与HIMM-WW的测量值在横向剂量分布和积分剂量深度曲线方面展现出良好的一致性。结论：SPEEDO程序可以准确快速地实现碳离子的蒙特卡罗剂量计算。
Abstract:
Abstract: Objective To develop a rapid and accurate Monte Carlo program (simplified code for dosimetry of carbon ions, SPEEDO) for carbon ion therapy. Methods For electromagnetic process, type II condensed history simulation scheme and continuous slowing down approximation were used to simulate energy straggling, range straggling, multiple scattering, and ionization processes. For nuclear interaction, 5 types of target nuclei were considered, including hydrogen, carbon, nitrogen, oxygen, and calcium. The produced secondary charged particles followed the same condensed history framework. The study simulated the transport of carbon ions in 4 materials (water, soft tissues, lung, and bone), and the calculated doses were validated against TOPAS (a Monte Carlo simulation software for radiotherapy physics), followed by a comparison with dose measurements in a water phantom from the HIMM-WW (a medical heavy-ion accelerator facility in Wuwei). Results SPEEDOs simulation results showed good consistency with TOPAS. For each material, in the voxel region where the physical dose was greater than 10% of the maximum dose point, the relative maximum dose error of both was less than 2%. At treatment energy of 400 MeV/u, SPEEDOs computation time was significantly less than that of TOPAS (13.8 min vs 105.0 min). SPEEDOs calculation results also showed good agreement with HIMM-WW measurements in terms of lateral dose distribution and integrated dose depth curve. Conclusion SPEEDO program can accurately and rapidly perform Monte Carlo dose calculations for carbon-ion therapy.

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备注/Memo

备注/Memo:
【收稿日期】2024-04-19 【基金项目】国家自然科学基金（12275372）；国家重点研发计划（2017YFC0107504）；安徽省重点研究与开发计划（2023s07020020）；中国科学技术大学双一流医学物理与生物医学工程交叉学科平台（YD2140000601）；中国科学技术大学新医学创新团队项目 （YD2140002002） 【作者简介】吴晋，硕士研究生，研究方向：碳离子放疗剂量的蒙特卡罗计算方法，E-mail: wujin1111@mail.ustc.edu.cn
更新日期/Last Update: 2024-10-29