[1]赵文娟,许碧纯,陈迪,等.基于多对多双重筛选逐步回归法进行不同位置食管癌形态学和剂量学的相关性分析及预测[J].中国医学物理学杂志,2024,41(12):1486-1493.[doi:DOI:10.3969/j.issn.1005-202X.2024.12.005]
　ZHAO Wenjuan,XU Bichun,et al.Analysis and prediction of the correlations between morphological and dosimetric parameters in different locations of esophageal cancer based on multi-to-multi double screening stepwise regression method[J].Chinese Journal of Medical Physics,2024,41(12):1486-1493.[doi:DOI:10.3969/j.issn.1005-202X.2024.12.005]
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基于多对多双重筛选逐步回归法进行不同位置食管癌形态学和剂量学的相关性分析及预测()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
41卷
期数:
2024年第12期
页码:
1486-1493
栏目:
医学放射物理
出版日期:
2024-12-17

文章信息/Info

Title:
Analysis and prediction of the correlations between morphological and dosimetric parameters in different locations of esophageal cancer based on multi-to-multi double screening stepwise regression method
文章编号:
1005-202X（2024）12-1486-08
作者:
赵文娟1; 2; 许碧纯2; 陈迪2; 曾福斌1; 2; 何洁1; 2; 蓝林臻3; 曾钰莎4; 张火俊2
1.上海理工大学健康科学与工程学院， 上海 200093； 2.海军军医大学附属上海长海医院放疗科， 上海 200433； 3.福建医科大学附属第一医院肿瘤中心放疗科， 福建 福州 350005； 4.福建省立医院放疗科， 福建 福州 350001
Author(s):
ZHAO Wenjuan1;  2;  XU Bichun2;  CHEN Di2;  ZENG Fubin1;  2;  HE Jie1;  2;  LAN Linzhen3;  ZENG Yusha4;  ZHANG Huojun2
1. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China 2. Department of Radiation Oncology, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China 3. Department of Radiotherapy, Cancer Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China 4. Department of Radiotherapy, Fujian Provincial Hospital, Fuzhou 350001, China
关键词:
食管癌; 调强放疗; 多对多双重筛选逐步回归法
Keywords:
Keywords: esophageal cancer intensity-modulated radiotherapy multi-to-multi double screening stepwise regression method
分类号:
R318；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2024.12.005
文献标志码:
A
摘要:
目的：通过多对多双重筛选逐步回归法分析不同位置的食管癌患者形态学与剂量学的相关性，并做简单预测。方法：回顾性分析2019~2021年在福建医科大学附属第一医院行放疗的中晚期食管癌患者105例。通过CT图像收集危及器官形态学参数。调强放疗计划在Raystation4.7进行。PTV-G和PTV-C的处方剂量分别为60 Gy/30 F和54 Gy/30 F。采用多对多双重筛选逐步回归法分析食管癌危及器官形态学参数与剂量学参数的相关性，并做简单预测。结果：肺与心脏的剂量体积参数与PTV-G体积、PTV-G长度、PTV-G横截面积、左右肺体积、肺长度、双肺体积有相关性（P<0.05）。对于上段食管癌：肺与心脏剂量体积参数与PTV-G体积、PTV-G长度、右肺体积具有相关性（P<0.05）；对于中段食管癌：肺、心脏与脊髓剂量体积参数与PTV-G体积、PTV-G长度、PTV-G横截面积、左右肺体积、肺长度具有相关性（P<0.05）；对于下段食管癌：肺、心脏与脊髓剂量体积参数与PTV-G体积、PTV-G长度、右肺体积、肺长度具有相关性（P<0.05）。结论：对于不同位置的肿瘤患者，应结合总体分析和分段分析两种影响因素进行参考，权衡肿瘤放疗疗效和放疗副反应，为肿瘤患者争取最大的获益。
Abstract:
Abstract: Objective To analyze the correlation between morphological and dosimetric parameters in patients with esophageal cancer at different locations using multi-to-multi double screening stepwise regression method, and to make simple predictions. Methods A retrospective analysis was conducted on 105 patients with advanced esophageal cancer who underwent radiotherapy at the First Affiliated Hospital of Fujian Medical University from 2019 to 2021. Morphological parameters of organs-at-risk were collected from CT images, and intensity-modulated radiotherapy plans were developed using Raystation4.7. The prescription doses for PTV-G and PTV-C were 60 Gy/30 F and 54 Gy/30 F, respectively. Multi-to-multi double screening stepwise regression method was employed to analyze the correlation between morphological and dosimetric parameters in esophageal cancer patients, and some preliminary predictions were provided. Results The dosimetric volume parameters of the lungs and heart were correlated with PTV-G volume, PTV-G length, PTV-G cross-sectional area, left and right lung volumes, lung length and total lung volume (P<0.05). For upper thoracic esophageal cancer, dosimetric volume parameters of the lungs and heart were correlated with PTV-G volume, PTV-G length, and right lung volume (P<0.05). For middle thoracic esophageal cancer, dosimetric volume parameters of the lungs, heart, and spinal cord were correlated with PTV-G volume, PTV-G length, PTV-G cross-sectional area, left and right lung volumes, and lung length (P<0.05). For lower thoracic esophageal cancer, dosimetric volume parameters of the lungs, heart, and spinal cord were correlated with PTV-G volume, PTV-G length, right lung volume, and lung length (P<0.05). Conclusion For patients with tumors at different locations, both overall and segmental analyses should be considered to balance therapeutic effect and side effects of radiotherapy, thereby maximizing the benefits for tumor patients.

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备注/Memo

备注/Memo:
【收稿日期】2024-06-11 【基金项目】GH145-33固海计划 【作者简介】赵文娟，硕士研究生，研究方向：肿瘤放射治疗、医学图像处理，E-mail: wenjuan.zh@foxmail.com 【通信作者】张火俊，博士，正高级，研究方向：肿瘤放射治疗，E-mail: huojunzh@163.com
更新日期/Last Update: 2024-12-20