颈内动脉狭窄血流动力学数值模拟-《中国医学物理学杂志》

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Title:: Numerical simulation of hemodynamics in internal carotid artery stenosis

文章编号:: 1005-202X（2024）10-1273-08

作者:: 彭红梅1; 张东威2; 左涛1; 刘宝治2; 陈阳1; 1.内蒙古民族大学物理与电子信息学院，内蒙古通辽 028000； 2.内蒙古民族大学附属医院神经内科，内蒙古通辽 028007

Author(s):: PENG Hongmei1; ZHANG Dongwei2; ZUO Tao1; LIU Baozhi2; CHEN Yang1; 1. College of Physics and Electronic Information, Inner Mongolia Minzu University, Tongliao 028000, China 2. Department of Neurology, Affiliated Hospital of Inner Mongolia Minzu University, Tongliao 028007, China

关键词:: 颈内动脉狭窄; 三维血管重建; 数值模拟; 两相流; 计算流体力学

Keywords:: Keywords: internal carotid artery stenosis?hree-dimensional vascular reconstruction?umerical simulation two-phase blood flow computational fluid dynamics

分类号:: R318；O357；O241

DOI:: DOI:10.3969/j.issn.1005-202X.2024.10.012

文献标志码:: A

摘要:: 目的：基于血流动力学数值模拟条件，探究对颈内动脉进行不同程度人工干预狭窄的颈动脉模型的血流动力学特性，并从血流动力学角度分析颈内动脉位置处产生狭窄及由于其狭窄导致脑部供血疾病的原因。方法：采集内蒙古民族大学附属医院提供的健康个体二维CT数据，应用医学建模软件MIMICS20.0将二维的颈动脉CT数据进行三维模型重建，然后借助3-Matic Medical软件，对颈动脉模型中的颈内动脉同一位置进行不同程度的人为干预狭窄，得到颈内动脉25%、50%、75%狭窄程度的颈动脉模型。经格式转化、边界条件设置、网格划分等操作后，导入计算流体力学软件FLUENT14.5进行颈动脉血管及血液两相流血流动力学数值模拟与分析。结果：比较颈内动脉同一位置3种不同狭窄程度下的血液流线及速度矢量图可知，随着狭窄程度的增大，颈动脉窦处血液的涡旋流动现象迅速减弱，而颈内动脉狭窄处上方和下方血液出现明显的涡旋流动，并且血液流动出现选择性偏流。颈内动脉狭窄程度从25％到50％再到75％的过程中，狭窄处的血管壁面压力始终较低，狭窄下方的血管壁面压力逐渐增大，为高压力区域。狭窄处为高切应力区域，并且狭窄位置上方和下方的低切应力范围明显变大。结论：利用计算机软件进行人为干预狭窄获取模型的技术进行实验研究具有方便、快捷的特点。颈内动脉狭窄从25％到50％再到75％时，颈动脉的血液流场发生明显改变，颈内动脉出现明显的涡旋流动现象，血管壁面的力学性质也发生一定变化。

Abstract:: Abstract: Objective To investigate the hemodynamic characteristics of carotid artery models with different degrees of artificial arterial stenosis based on hemodynamic numerical simulation, and to analyze causes of internal carotid artery stenosis and the diseases due to the stenosis from the perspective of hemodynamics. Methods Two-dimensional CT data of healthy individuals were collected from Affiliated Hospital of Inner Mongolia Minzu University, and the three-dimensional model of carotid artery was reconstructed from the two-dimensional CT data using medical modeling software MIMICS20.0. Subsequently, the obtained carotid artery model was imported to 3-Matic Medical software and interfered with various degrees of artificial internal carotid artery stenosis at the same location to obtain the models with 25%, 50% and 75% internal carotid artery stenosis. After format conversion, boundary condition setting and mesh generation, the models were imported to computational fluid dynamics software FLUENT14.5 for the hemodynamic numerical simulation and analysis of the carotid artery and two-phase blood flow. Results The comparison of the blood streamlines and velocity vector maps of 3 different degrees of internal carotid artery stenosis at the same location revealed that with the increase of stenosis severity, the phenomenon of blood vortex flow at the carotid sinus decreases rapidly, but obvious vortex flow appeared above and below the internal carotid artery stenosis, and the blood flow was selectively deflected. During the internal carotid artery stenosis from 25% to 50% and then to 75%, the pressure on the wall of internal carotid artery was always low, and the pressure on the wall of internal carotid artery was gradually increased, forming a high pressure area. There was high shear stress area at the stenosis, and the low shear stress ranges above and below the stenosis were obviously larger. Conclusion The technology of using computer software to obtain models with artificial stenosis is convenient and efficient. When the internal carotid artery stenosis increases from 25% to 50% and then to 75%, the blood flow of the carotid artery changes obviously, obvious vortex flow appears in the internal carotid artery, and the mechanical properties of the wall of the carotid artery also change.

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

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