[1]张晓辉,曹贤东,邵丹.131碘对Graves病合并甲状腺结节的疗效[J].中国医学物理学杂志,2023,40(11):1332-1335.[doi:DOI:10.3969/j.issn.1005-202X.2023.11.003]
　ZHANG Xiaohui,CAO Xiandong,SHAO Dan.Therapeutic effect of 131iodine on Graves hyperthyroidism with thyroid nodules[J].Chinese Journal of Medical Physics,2023,40(11):1332-1335.[doi:DOI:10.3969/j.issn.1005-202X.2023.11.003]
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131碘对Graves病合并甲状腺结节的疗效()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
40卷
期数:
2023年第11期
页码:
1332-1335
栏目:
医学放射物理
出版日期:
2023-11-24

文章信息/Info

Title:
Therapeutic effect of 131iodine on Graves hyperthyroidism with thyroid nodules
文章编号:
1005-202X（2023）11-1332-04
作者:
张晓辉1; 曹贤东2; 邵丹3
1.深圳市第三人民医院核医学科， 广东 深圳 518100； 2.深圳市第三人民医院统计室， 广东 深圳 518100； 3.广东省人民医院核医学科， 广东 广州 510000
Author(s):
ZHANG Xiaohui1;  CAO Xiandong2;  SHAO Dan3
1. Department of Nuclear Medicine, the Third People′s Hospital of Shenzhen, Shenzhen 518100, China 2. Department of Statistics, the Third People′s Hospital of Shenzhen, Shenzhen 518100, China 3. Department of Nuclear Medicine, Guangdong Provincial Peoples Hospital, Guangzhou 510000, China
关键词:
Graves病; 131碘; 内放射治疗; 甲状腺结节
Keywords:
Keywords: Graves disease 131iodine inner radiation therapy thyroid nodule
分类号:
R817.8
DOI:
DOI:10.3969/j.issn.1005-202X.2023.11.003
文献标志码:
A
摘要:
目的：观察Graves病（GH）合并甲状腺结节患者131I碘（131I）治疗后甲状腺结节的大小变化，以了解131I在治疗GH的同时对合并的甲状腺结节的疗效。方法：回顾性分析GH合并甲状腺结节患者行个体化131I治疗的106例病例资料，共发现193个结节，根据结节大小分为3组，A组：结节直径≤5 mm，B组：5 mm<结节≤10 mm，c组：结节="">10 mm。分析3组病例行131I治疗前后结节大小的变化，了解131I治疗后不同结节大小的治疗效果，并采用多重线性回归方法分析与治疗效果相关的因素。结果：A组结节共59个，131I治疗甲亢痊愈后结节消失83.33%、结节变小7.41%、结节不变或增大9.26%，总有效率90.74%；B组结节共108个，131I治疗甲亢痊愈后结节消失61.82%、结节变小21.82%、结节不变或增大16.36%，总有效率为83.64%；C组结节共26个，131I治疗甲亢痊愈后结节消失31.58%、结节变小31.58%、结节不变或增大36.84%，总有效率为63.16%。3组结节治疗前后变化差异有统计学意义（P<0.05）。甲状腺结节大小、年龄与治疗效果有相关性，而甲状腺质量、个体化服131I剂量、性别、总三碘甲状腺原氨酸、总甲状腺素、促甲状腺素、2 h吸碘率、24 h吸碘率等因素与治疗效果均无相关性。结论：131I治疗GH合并甲状腺良性小结节效果明显，尤以小于10 mm的小结节效果显著。
Abstract:
Abstract: Objective To observe the changes in the size of thyroid nodules after 131iodine (131I) therapy in patients with Graves hyperthyroidism (GH) and thyroid nodules for exploring the efficacy of 131I for thyroid nodules while treating GH. Methods A retrospective analysis was conducted on 106 patients with GH and thyroid nodules receiving individualized 131I therapy. A total of 193 nodules were identified and categorized into 3 groups according to their size (group A: nodule diameter ≤ 5 mm, group B: 5 mm < nodule diameter ≤ 10 mm, group C: nodule diameter >10 mm). The changes in nodule size before and after 131I therapy were analyzed in the 3 groups to analyze the therapeutic effects of 131I on nodules of different sizes. Multiple linear regression analysis was used to identify factors related to therapeutic effects. Results In group A, there were 59 thyroid nodules, of which 83.33% disappeared after 131I therapy, 7.41% decreased in size, and 9.26% remained unchanged or enlarged, with an overall response rate of 90.74%. In group B, there were 108 thyroid nodules, with 61.82% disappearing after 131I therapy, 21.82% decreasing in size, and 16.36% remaining unchanged or enlarged, and the overall response rate was 83.64%. There were 26 nodules in group C, with 31.58% disappearing after 131I therapy, 31.58% decreasing in size, and 36.84% remaining unchanged or enlarged, and the overall response rate was 63.16%. The nodule size in the 3 groups changed differently (P<0.05). Nodule size and age were found to be correlated with therapeutic effect, while thyroid weight, individualized dose of 131I, gender, TT3, TT4, TSH, 2-h iodine uptake rate, and 24-h iodine uptake rate had no correlation with therapeutic effect. Conclusion 131I therapy is effective for GH and benign small nodules in the thyroid, especially for nodules smaller than 10 mm.

相似文献/References:

[1]何芳,王月慧,黄金城,等. 公式法碘-131治疗Graves病甲亢甲状腺吸收剂量误差分析[J].中国医学物理学杂志,2017,34(9):879.[doi:DOI:10.3969/j.issn.1005-202X.2017.09.004]
　[J].Chinese Journal of Medical Physics,2017,34(11):879.[doi:DOI:10.3969/j.issn.1005-202X.2017.09.004]

备注/Memo

备注/Memo:
【收稿日期】2023-08-12 【基金项目】国家自然科学基金青年科学基金（KY012021162） 【作者简介】张晓辉，硕士，副主任医师，研究方向：甲状腺疾病的核素治疗，E-mail: 48555775@qq.com
更新日期/Last Update: 2023-11-24