[1]徐承裕,吴玉凤,周丹.低频rTMS联合帕罗西汀治疗对惊恐障碍患者临床症状和社会功能的影响[J].中国医学物理学杂志,2023,40(12):1554-1557.[doi:DOI:10.3969/j.issn.1005-202X.2023.12.015]
　XU Chengyu,WU Yufeng,ZHOU Dan.Effects of low-frequency rTMS combined with paroxetine on clinical symptoms and social abilities in patients with panic disorder[J].Chinese Journal of Medical Physics,2023,40(12):1554-1557.[doi:DOI:10.3969/j.issn.1005-202X.2023.12.015]
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低频rTMS联合帕罗西汀治疗对惊恐障碍患者临床症状和社会功能的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
40卷
期数:
2023年第12期
页码:
1554-1557
栏目:
医学生物物理
出版日期:
2023-12-27

文章信息/Info

Title:
Effects of low-frequency rTMS combined with paroxetine on clinical symptoms and social abilities in patients with panic disorder
文章编号:
1005-202X（2023）12-1554-04
作者:
徐承裕1; 吴玉凤2; 周丹3
1.梧州市第二人民医院精神科， 广西 梧州 543001； 2.桂东人民医院感染性疾病二科， 广西 梧州 543001； 3.东莞清溪医院神经外科， 广东 东莞 523658
Author(s):
XU Chengyu1;  WU Yufeng2;  ZHOU Dan3
1. Department of Psychiatry, Wuzhou Second Peoples Hospital, Wuzhou 543001, China 2. The Second Department of Infectious Diseases, Guidong Peoples Hospital of Guangxi Zhuang Autonomous Region, Wuzhou 543001, China 3. Department of Neurosurgery, Dongguan Qingxi Hospital, Dongguan 523658, China
关键词:
惊恐障碍; 低频重复经颅磁刺激; 帕罗西汀; 临床症状; 社会功能
Keywords:
Keywords: panic disorder low-frequency repetitive transcranial magnetic stimulation paroxetine clinical symptom social ability
分类号:
R749.99
DOI:
DOI:10.3969/j.issn.1005-202X.2023.12.015
文献标志码:
A
摘要:
目的：观察低频重复经颅磁刺激（rTMS）联合帕罗西汀治疗对惊恐障碍（PD）患者临床症状和社会功能的影响。方法：将90例PD患者随机分为观察组和对照组，每组45例。观察组采用低频rTMS联合帕罗西汀进行治疗，对照组仅用帕罗西汀治疗，均持续治疗6周。于治疗前后，采用PD严重程度量表（PDSS）、汉密尔顿焦虑量表（HAMA）对患者临床症状进行评估，观察其临床疗效；采用大体功能评定量表（GAF）、领悟社会支持量表（PSSS）对患者进行社会功能的评价。观察患者治疗期间不良反应发生情况。结果：治疗4周及6周后，观察组患者的PDSS和HAMA评分均低于对照组（F时间分别为566.213、533.124，P<0.05；F组间分别为13.211、4.466，P<0.05）；观察组患者的GAF和PSSS评分均高于对照组（F时间分别为486.312、497.112，P<0.05；F组间分别为62.601、123.510，P<0.05）。观察患者治疗4周和6周后有效率分别为80.00%和91.11%，均高于对照组的60.00%和71.11%（P<0.05）。观察组总不良反应发生率与对照组比较无统计学意义（22.22% vs 17.78%，P>0.05）。结论：PD患者应用低频rTMS联合帕罗西汀可有效改善其临床症状，缓解焦虑情绪，提高临床疗效，改善患者社会功能，且具有一定的安全性，较仅用帕罗西汀受益。
Abstract:
Abstract: Objective To explore the effects of the combination of low-frequency repetitive transcranial magnetic stimulation (rTMS) and paroxetine on clinical symptoms and social abilities in patients with panic disorder. Methods A total of 90 patients with panic disorder were randomly divided into observation group (n=45, low-frequency rTMS combined with paroxetine) and control group (n=45, paroxetine alone). All were continuously treated for 6 weeks. The clinical symptoms were evaluated with panic disorder severity scale (PDSS) and Hamilton anxiety scale (HAMA) for assessing the therapeutic effect and the social abilities were evaluated with global assessment function (GAF) and perceived social support scale (PSSS). The occurrence of adverse reactions during treatment was recorded. Results After 4 and 6 weeks of treatment, compared with control group, observation group had lower PDSS score and HAMA score (Ftime=566.213, 533.124, P<0.05 Fbetween-group=13.211, 4.466, P<0.05), and higher GAF score and PSSS score (Ftime=486.312, 497.112, P<0.05 Fbetween-group=62.601, 123.510, P<0.05). After 4 and 6 weeks of treatment, the response rates in observation group were 80.00% and 91.11%, higher than 60.00% and 71.11% in control group (P<0.05). There was no significant difference in total incidence of adverse reactions between observation group and control group (22.22% vs 17.78%, P>0.05). Conclusion The combination of low-frequency rTMS and paroxetine can effectively relieve anxiety, improve clinical symptoms, therapeutic effect and social abilities in patients with panic disorder, with certain safety and bringing more benefits as compared with paroxetine alone.

相似文献/References:

[1]陈亮,陈洁,金戈,等. 低频重复经颅磁刺激治疗卒中后抑郁疗效的Meta分析[J].中国医学物理学杂志,2019,36(6):736.[doi:DOI:10.3969/j.issn.1005-202X.2019.06.023]
　CHEN Liang,CHEN Jie,JIN Ge,et al.Therapeutic efficacy of low-frequency repetitive transcranial magnetic stimulation in post-stroke depression: a Meta-analysis[J].Chinese Journal of Medical Physics,2019,36(12):736.[doi:DOI:10.3969/j.issn.1005-202X.2019.06.023]

备注/Memo

备注/Memo:
【收稿日期】2023-06-07 【基金项目】广西壮族自治区卫生健康委员会科研课题（Z20200002） 【作者简介】徐承裕，副主任医师，研究方向：临床精神疾病，E-mail: tqb2023@163.com
更新日期/Last Update: 2023-12-27