[1]张恒,逯迈.磁感应热疗作用于胰腺癌模型热场分布[J].中国医学物理学杂志,2023,40(11):1408-1417.[doi:DOI:10.3969/j.issn.1005-202X.2023.11.015]
　ZHANG Heng,LU Mai.Thermal field distribution of pancreatic cancer model treated with magnetic induction hyperthermia[J].Chinese Journal of Medical Physics,2023,40(11):1408-1417.[doi:DOI:10.3969/j.issn.1005-202X.2023.11.015]
点击复制

磁感应热疗作用于胰腺癌模型热场分布()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
40卷
期数:
2023年第11期
页码:
1408-1417
栏目:
医学生物物理
出版日期:
2023-11-24

文章信息/Info

Title:
Thermal field distribution of pancreatic cancer model treated with magnetic induction hyperthermia
文章编号:
1005-202X（2023）11-1408-10
作者:
张恒; 逯迈
兰州交通大学光电技术与智能控制教育部重点实验室， 甘肃 兰州 730070
Author(s):
ZHANG Heng;  LU Mai
Key Laboratory of Optoelectronic Technology and Intelligent Control of Ministry of Education, Lanzhou Jiaotong University, Lanzhou 730070, China
关键词:
胰腺导管腺癌; 磁感应热疗; 有限元分析; 磁介质
Keywords:
Keywords: pancreatic ductal adenocarcinoma magnetic fluid hyperthermia finite element analysis magnetic medium
分类号:
R318；R735.9
DOI:
DOI:10.3969/j.issn.1005-202X.2023.11.015
文献标志码:
A
摘要:
为了对磁感应热疗作用于胰腺导管腺癌时的效果进行研究，根据真实的人体数据构建三维的人体腹部、胰腺、胰腺导管和肿瘤模型，采取亥姆霍兹线圈用作产生交变磁场的热疗装置。在有限元仿真分析软件COMSOL中进行电磁与传热模块的耦合后，得到磁感应热疗作用于胰腺导管腺癌时的磁场和温度场的仿真结果。结果表明，治疗区域的空间磁场分布均匀，温度场分布满足热疗需要。胰腺导管腺癌在进行磁感应热疗时，肿瘤组织的温度可以迅速升高，达到42 ℃以上，而周围正常组织升温不显著。此外，研究还证实了胰腺导管周围存在的大血管、磁流体溢出等因素对热疗的疗效没有太大的影响，仿真结果能够为胰腺导管腺癌的磁感应热疗临床实践提供参考。
Abstract:
Abstract: The effect of magnetic induction hyperthermia on pancreatic ductal adenocarcinoma (PDAC) is analyzed using a three-dimensional model of human abdomen, pancreas, pancreatic duct and tumor constructed based on real human data, and a Helmholtz coil is used as a hyperthermia device to generate alternating magnetic fields. The simulation results of magnetic field and temperature field of magnetic induction hyperthermia acting on PDAC are obtained after coupling electromagnetic and heat transfer modules in the finite element calculation and analysis software COMSOL. The results reveal that the spatial distribution of the magnetic field in the treatment area is relatively uniform, and that the temperature field distribution can provide the optimal temperature for hyperthermia. When magnetic induction hyperthermia is performed for PDAC, the temperature of the tumor tissue can rise rapidly to over 42 ℃, while the surrounding normal tissue does not heat up remarkably. In addition, the study also confirmes that the factors such as the existence of large blood vessels near the pancreatic ducts and magnetic fluid overflow have trivial effects on the efficacy of hyperthermia treatment. The simulation results can be a reference for the clinical implementation of magnetic induction hyperthermia for PDAC.

相似文献/References:

[1]李政晓,李昇霖,薛彩强,等.基于术前增强CT构建列线图模型预测胰腺导管腺癌R0切除[J].中国医学物理学杂志,2022,39(8):957.[doi:DOI:10.3969/j.issn.1005-202X.2022.08.007]
　LI Zhengxiao,,et al.Using nomogram model based on preoperative contrast-enhanced CT to predict R0 resection of pancreatic ductal adenocarcinoma[J].Chinese Journal of Medical Physics,2022,39(11):957.[doi:DOI:10.3969/j.issn.1005-202X.2022.08.007]
[2]郭思玮,逯迈.大鼠磁感应热疗的线圈设计与仿真分析[J].中国医学物理学杂志,2024,41(1):101.[doi:DOI:10.3969/j.issn.1005-202X.2024.01.015]
　GUO Siwei,LU Mai.Coil design and simulation analysis of magnetic induction hyperthermia in rats[J].Chinese Journal of Medical Physics,2024,41(11):101.[doi:DOI:10.3969/j.issn.1005-202X.2024.01.015]

备注/Memo

备注/Memo:
【收稿日期】2023-07-05 【基金项目】国家自然科学基金（51567015, 51867014） 【作者简介】张恒，硕士，研究方向：磁感应热疗，E-mail: zhangheng0921@126.com 【通信作者】逯迈，博士，教授，博士生导师，研究方向：生物医学电磁学、电磁暴露安全评估，E-mail: mai.lu@hotmail.com
更新日期/Last Update: 2023-11-24