基于近红外光谱的脑组织氧监测系统研发与验证-《中国医学物理学杂志》

文章信息/Info

Title:: Development and validation of a novel cerebral oximeter using near-infrared spectroscopy

作者:: 蔡世杰1; 2; 李翰林1; 2; 沈昭3; 于辉3; 叶继伦2; 3; 张旭1; 2; 1.深圳市生物医学工程重点实验室，广东深圳 518060； 2.深圳大学医学部生物医学工程学院，广东深圳 518060； 3.广东宝莱特医疗技术研究院有限公司，广东珠海 519080

Author(s):: CAI Shijie1; 2; LI Hanlin1; 2; SHEN Zhao3; YU Hui3; YE Jilun2; 3; ZHANG Xu1; 2; 1. Shenzhen Key Laboratory for Biomedical Engineering, Shenzhen 518060, China 2. School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China 3. Guangdong Biolight Meditech Research Institute Co., Ltd., Zhuhai 519080, China

Keywords:: Keywords: regional cerebral oxygen saturation arterial blood oxygen saturation near-infrared spectroscopy spatially resolved spectroscopy controlled hypoxia experiment

摘要:: 结合修正Lambert-Beer定律和空间分辨光谱技术，提出一种基于三波长的脑组织氧饱和度监测系统。搭建脑组织氧饱和度（rSO2）测量平台，从光谱稳定性和本底噪声验证系统可靠性，建立受控低氧试验并招募18名志愿者，研究rSO2随吸入氧阶梯平台变化的趋势以及rSO2与动脉血氧饱和度之间的关系。结果表明，该测量系统可以有效监测rSO2，测试结果符合测量要求。受控低氧序列中，随吸入氧浓度下降，rSO2均呈下降趋势，且个体rSO2与动脉血氧饱和度具有较高的相关性。

Abstract:: Abstract: A cerebral oximeter based on 3-wavelength spatially resolved spectroscopy and the modified Lambert-Beer law is proposed. A platform for monitoring the regional cerebral oxygen saturation (rSO2) is established, and the system reliability is verified through spectral stability and background noise test. Eighteen volunteers are recruited to participate in the controlled hypoxia test for exploring the trend of rSO2 with the sequence of stepped hypoxia platform and discussing the relationship between rSO2 and arterial blood oxygen saturation. The results show that the established system can effectively monitor rSO2 and meet the measurement requirements. During the controlled hypoxia sequence, as the fraction of inspired oxygen decreases, rSO2 shows a downward trend, and the individual rSO2 has a high correlation with arterial blood oxygen saturation.