用于经导管二尖瓣置换术的支架有限元评估-《中国医学物理学杂志》

文章信息/Info

Title:: Finite element evaluation of stents for transcatheter mitral valve replacement

作者:: 陈一然1; 贺照明1; 2; 1.江苏大学流体机械工程技术研究中心生物医学工程系，江苏镇江 212013； 2.德州理工大学机械工程系，拉伯克 79409

Author(s):: CHEN Yiran1; HE Zhaoming1; 2; 1. Department of Biomedical Engineering, Research Center of Fluid Machinery Engineering and Technology, Jiangsu University, Zhenjiang 212013, China 2. Department of Mechanical Engineering, Texas Tech University, Lubbock 79409, USA

Keywords:: Keywords: transcatheter mitral valve replacement mitral valve stent finite element analysis

摘要:: 目的：提出一种经导管二尖瓣置换术支架设计，评估支架与瓣叶植入后在体内相互作用产生的变形情况并分析其力学行为。方法：应用有限元方法，建立支架瓣叶组合模型，在瓣叶上施加压强载荷模拟其在人体内闭合的过程，分析其变形情况和应力应变结果以及受此影响的疲劳寿命。结果：本支架受瓣叶牵拉产生的最大顶端位移为0.24 mm，周期性应变的疲劳寿命约为2.05×108次。结论：变形程度可接受但不可忽视，瓣叶的周期性牵拉对支架的影响可使其在人体内正常工作5~9年。

Abstract:: Abstract: Objective To propose a stent design for transcatheter mitral valve replacement, and to evaluate the deformation caused by the interaction between the stent and the valve leaflets in vivo and analyze its mechanical behavior. Methods The finite element method was used to establish a composite model of the stent and leaflets, and a pressure load was applied on the leaflets to simulate its closing process in the human body. The stent deformation, stress-strain results, and fatigue life affected by the pressure load were analyzed. Results The maximum apical displacement of the stent was about 0.24 mm, and the fatigue life under periodic strain was about 2.05×108 times. Conclusion The degree of stent deformation is acceptable but should not to be neglected. Considering only the periodic traction of the valve leaflets on the stent, the stent can work normally for 4-9 years.