[1]赵瑞,曹洋森,高行新,等.基于胸部仿真模体研究CT层厚对射波刀放疗靶区剂量分布的影响[J].中国医学物理学杂志,2023,40(6):667-671.[doi:DOI:10.3969/j.issn.1005-202X.2023.06.002]
　ZHAO Rui,CAO Yangsen,GAO Xingxin,et al.Analysis of effects of CT slice thickness on target dose distribution in Cyberknife radiotherapy using chest phantom[J].Chinese Journal of Medical Physics,2023,40(6):667-671.[doi:DOI:10.3969/j.issn.1005-202X.2023.06.002]
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基于胸部仿真模体研究CT层厚对射波刀放疗靶区剂量分布的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
40卷
期数:
2023年第6期
页码:
667-671
栏目:
医学放射物理
出版日期:
2023-06-27

文章信息/Info

Title:
Analysis of effects of CT slice thickness on target dose distribution in Cyberknife radiotherapy using chest phantom
文章编号:
1005-202X（2023）06-0667-05
作者:
赵瑞1; 曹洋森2; 高行新1; 王震岳1; 李莎1; 田种泽1
1.联勤保障部队第940医院放疗科， 甘肃 兰州730050； 2.海军军医大学附属上海长海医院放疗科， 上海 200433
Author(s):
ZHAO Rui1;  CAO Yangsen2;  GAO Xingxin1;  WANG Zhenyue1;  LI Sha1;  TIAN Zhongze1
1. Department of Radiation Oncology, the 940th Hospital of Joint Logistics Force, Lanzhou 730050, China 2. Department of Radiation Oncology, Changhai Hospital, Naval Medical University, Shanghai 200433, China
关键词:
胸部仿真模体; 射波刀; CT层厚; 治疗计划; 剂量
Keywords:
Keywords: chest phantom Cyberknife CT slice thickness treatment plan dose
分类号:
R318；R815
DOI:
DOI:10.3969/j.issn.1005-202X.2023.06.002
文献标志码:
A
摘要:
目的：研究不同CT层厚对射波刀放疗靶区剂量分布的影响。方法：①使用胸部仿真模体对不同大小模拟肿瘤TUMOR01~TUMOR05以1.0~5.0 mm CT层厚行常规CT模拟定位和重建；②使用各模拟肿瘤不同层厚CT序列以固定Auto-Shells、处方剂量、处方剂量线及限光筒制定射波刀放疗计划，记录放疗靶区计算结果；③分别将各模拟肿瘤不同CT层厚放疗计划移植至1.0 mm CT层厚放疗计划，记录放疗计划移植后放疗靶区变化结果；④比较各模拟肿瘤不同CT层厚放疗计划移植前后放疗靶区的变化情况。结果：除模拟肿瘤TUMOR01放疗靶区最大剂量（Dmax）与CT层厚表现为弱相关性（|r|＝0.20）外，模拟肿瘤TUMOR02~TUMOR05放疗靶区Dmax及各模拟肿瘤放疗靶区最小剂量（Dmin）、适形度指数（CI）、新适形度指数（nCI）、覆盖率Coverage与CT层厚均表现为强相关性（|r|>0.70），各模拟肿瘤放疗靶区Dmin、覆盖率Coverage与CT层厚呈负相关，放疗靶区Dmax、CI、nCI与CT层厚呈正相关，其相关显著性水平不同；当模拟肿瘤TUMOR01 CT层厚>2 mm时，放疗靶区Dmin、nCI、覆盖率Coverage数值变化尤为明显，其变化范围分别为9.89~15.29 Gy、0.19~0.76、11.44％~29.94％。结论：CT层厚显著影响射波刀放疗靶区剂量分布，对体积较小肿瘤的影响尤为明显。
Abstract:
Abstract: Objective To study the effects of CT slice thickness on the target dose distribution in Cyberknife radiotherapy. Methods The conventional CT locating and reconstruction were carried out on the chest phantom for the simulated tumors TUMOR01-TUMOR05 with CT slice thicknesses of 1.0-5.0 mm. For each simulated tumor, the Cyberknife radiotherapy plans of the CT sequences with different slice thicknesses were made with the fixed Auto-Shells, prescription dose, prescription dose line and collimator, and the calculation results were recorded. Then the treatment plans with different CT slice thicknesses were transplanted to the treatment plan with 1.0 mm slice thickness, and the dosimetric changes after plan transplantation were recorded. The changes in the radiotherapy target area before and after transplantation of radiotherapy plans of different CT slice thicknesses were compared. Results Except that the Dmax of the TUMOR01 target area showed a weak correlation to the CT slice thickness (|r|=0.20), the Dmax of the TUMOR02-TUMOR05 target areas, and the Dmin, CI, nCI and coverage of TUMOR01-TUMOR05 target areas had strong correlations to the CT slice thickness (|r|>0.70). The Dmin and the coverage of TUMOR01-TUMOR05 target areas were negatively correlated to the CT slice thickness, while the Dmax, CI and nCI were positively correlated to the CT slice thickness, and their significance levels were different. The Dmin, nCI and coverage of the TUMOR01 target area were changed significantly with the slice thickness larger than 2 mm, and their changed ranges were 9.89-15.29 Gy, 0.19-0.76 and 11.44%-29.94%, respectively. Conclusion CT slice thickness affects the target dose distribution in Cyberknife radiotherapy significantly, and it is extremely significant for the smaller tumor.

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备注/Memo

备注/Memo:
【收稿日期】2023-02-10 【基金项目】上海申康临床“五新”创新研发项目（SHDC2020CR3087B） 【作者简介】赵瑞，副主任技师，主要从事放射技术方面的研究，E-mail: zrznl318@sina.com 【通信作者】曹洋森，副主任技师，主要从事肿瘤放射物理工作，E-mail: caoyangsen@163.com
更新日期/Last Update: 2023-06-28