[1]杜永欢,杨悦,董顺成,等.应用约束最小二乘方滤波法校正放疗3D剂量验证辐射荧光图像[J].中国医学物理学杂志,2023,40(9):1083-1090.[doi:DOI:10.3969/j.issn.1005-202X.2023.09.005]
　DU Yonghuan,YANG Yue,DONG Shuncheng,et al.Fluorescence image correction with constrained least squares filtering method for 3D dose verification in radiotherapy[J].Chinese Journal of Medical Physics,2023,40(9):1083-1090.[doi:DOI:10.3969/j.issn.1005-202X.2023.09.005]
点击复制

应用约束最小二乘方滤波法校正放疗3D剂量验证辐射荧光图像()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
40卷
期数:
2023年第9期
页码:
1083-1090
栏目:
医学放射物理
出版日期:
2023-09-26

文章信息/Info

Title:
Fluorescence image correction with constrained least squares filtering method for 3D dose verification in radiotherapy
文章编号:
1005-202X（2023）09-1083-08
作者:
杜永欢; 杨悦; 董顺成; 张佩毅; 文万信
苏州大学医学部放射医学与防护学院， 江苏 苏州 215123
Author(s):
DU Yonghuan;  YANG Yue;  DONG Shuncheng;  ZHANG Peiyi;  WEN Wanxin
School of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou 215123, China
关键词:
剂量验证; 约束最小二乘方滤波; 点扩散函数; Gamma通过率
Keywords:
Keywords: dose verification constrained least squares filtering point spread function Gamma passing rate
分类号:
R318；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2023.09.005
文献标志码:
A
摘要:
目的：通过约束最小二乘方滤波法对塑料闪烁体在射束辐照下的荧光图像进行校正，提高基于闪烁体辐射荧光的放疗3D剂量验证系统的准确性。方法：首先对正交三视角度拍摄的辐射荧光投影图进行去噪预处理，同时通过Zemax光学模拟软件计算出成像系统的点扩散函数（PSF），并用洛伦兹函数对其进行拟合调整。其次使用约束最小二乘方滤波法对去噪预处理后的正交三视投影图进行去卷积处理。最后将校正前后图像进行3D剂量分布重建，并分别与Pinnacle3治疗计划系统中计算的剂量分布数据进行比较。结果：对于4 cm×4 cm、3 cm×3 cm方野照射，应用约束最小二乘方滤波法校正后的平均2D Gamma通过率（阈值10%，3%/3 mm标准）分别提高了22.95%和5.76%，中心轴上的百分深度剂量（PDD）曲线的均方根误差（RMSE）值分别降低了1.13%和0.63%。对于2 cm×2 cm方野照射，滤波校正后的平均2D Gamma通过率（阈值20%，3%/3 mm标准）提高了1.54%，PDD曲线的RMSE值降低了0.49%。结论：在3D剂量重建前对正交三视投影图进行图像校正可以有效提高基于塑闪辐射荧光3D剂量验证系统的准确性。
Abstract:
Abstract: Objective To correct the fluorescence image of the plastic scintillators under beam irradiation using the constrained least squares filtering method for improving the accuracy of 3D radiation dose verification system based on scintillator fluorescence. Methods The radiation-induced fluorescence map taken from orthogonal 3-view angle was denoised, and the point spread function (PSF) of the imaging system was calculated using Zemax optical simulation software and adjusted by Lorentz function. Then, the constrained least squares filtering method was used for the deconvolution of the orthogonal 3-view projection image after denoising. The 3D dose distribution reconstruction was carried out on the images before and after correction, and the results were compared with the dose distribution calculated in the Pinnacle3 treatment planning system. Results For the square radiation fields of 4 cm×4 cm and 3 cm×3 cm, the average 2D Gamma passing rates (threshold 10%, 3%/3 mm) after correction with the constrained least squares filtering method were increased by 22.95% and 5.76%, respectively, and the root-mean-square errors (RMSE) of the percentage depth dose (PDD) curve on the center axis were reduced by 1.13% and 0.63%, respectively. For the square radiation field of 2 cm×2 cm, the average 2D Gamma pass rate (threshold 20%, 3%/3 mm) after filtering correction was increased by 1.54%, and the RMSE of the PDD curve was reduced by 0.49%. Conclusion The correction of orthogonal 3-view projection image before 3D dose reconstruction can effectively improve the accuracy of 3D radiation dose verification system based on scintillator fluorescence.

相似文献/References:

[1]张富利,王雅棣,许卫东,等.应用两种三维探测器阵列进行螺旋断层调强放疗计划剂量验证[J].中国医学物理学杂志,2015,32(02):218.[doi:10.3969/j.issn.1005-202X.2015.02.015]
[2]曾 彪,张九堂,席许平.单中心上下半野调强放射治疗的物理剂量验证[J].中国医学物理学杂志,2015,32(01):17.[doi:10.3969/j.issn.1005-202X.2015.01.005]
[3]任 强,王 玉,曹瑞芬,等.基于非晶硅电子射野影像装置的精确剂量刻度方法[J].中国医学物理学杂志,2015,32(01):38.[doi:10.3969/j.issn.1005-202X.2015.01.010]
[4]刘 浩,王 新,李公平,等.用二维电离室矩阵验证宫颈癌腔内放疗剂量分布[J].中国医学物理学杂志,2014,31(04):4988.[doi:10.3969/j.issn.1005-202X.2014.04.004]
[5]张富利,蒋华勇,王雅棣,等.应用一维、二维、三维探测器阵列进行螺旋断层调强放疗计划剂量验证[J].中国医学物理学杂志,2014,31(06):5230.[doi:10.3969/j.issn.1005-202X.2014.06.002]
[6]易金玲,金献测,周永强,等.鼻咽癌IMRT与VMAT治疗的计划与剂量验证比较研究[J].中国医学物理学杂志,2013,30(01):3859.[doi:10.3969/j.issn.1005-202X.2013.01.006]
[7]方明明,周希法,卢绪菁,等.使用Compass系统进行调强验证的一些探讨[J].中国医学物理学杂志,2013,30(01):3870.[doi:10.3969/j.issn.1005-202X.2013.01.008]
[8]陆佳扬,林珠,陈志坚,等.基于Delta4对Truebeam容积调强放疗(VMAT)计划的验证评估[J].中国医学物理学杂志,2013,30(03):4118.[doi:10.3969/j.issn.1005-202X.2013.03.008]
[9]谭丽娜,孙晓欢,马奎,等.三维剂量验证系统Delta4在容积旋转调强计划剂量验证中的应用[J].中国医学物理学杂志,2013,30(06):4497.[doi:10.3969/j.issn.1005-202X.2013.06.007]
[10]陈上河,王 石,吴朝霞,等.基于蒙特卡罗模拟的CyberKnife病人治疗计划剂量验证[J].中国医学物理学杂志,2015,32(04):451.[doi:10.3969/j.issn.1005-202X.2015.04.001]
　[J].Chinese Journal of Medical Physics,2015,32(9):451.[doi:10.3969/j.issn.1005-202X.2015.04.001]

备注/Memo

备注/Memo:
【收稿日期】2023-03-13 【作者简介】杜永欢，硕士，研究方向：医学物理学，E-mail:1370561240 @qq.com 【通信作者】文万信，博士，研究员，研究方向：医学物理、辐射探测，E-mail: wxwen@suda.edu.cn
更新日期/Last Update: 2023-09-26