[1]江承川,李茉莉,刘莎,等.不同剂量调强放疗联合同步化疗对局部晚期肺癌患者生存期和毒副反应的影响[J].中国医学物理学杂志,2022,39(11):1345-1348.[doi:DOI:10.3969/j.issn.1005-202X.2022.11.005]
　JIANG Chengchuan,LI Moli,LIU Sha,et al.Effects of different doses of intensity-modulated radiotherapy combined with concurrent chemotherapy on survival and toxicity in patients with locally advanced lung cancer[J].Chinese Journal of Medical Physics,2022,39(11):1345-1348.[doi:DOI:10.3969/j.issn.1005-202X.2022.11.005]
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不同剂量调强放疗联合同步化疗对局部晚期肺癌患者生存期和毒副反应的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第11期
页码:
1345-1348
栏目:
医学放射物理
出版日期:
2022-11-25

文章信息/Info

Title:
Effects of different doses of intensity-modulated radiotherapy combined with concurrent chemotherapy on survival and toxicity in patients with locally advanced lung cancer
文章编号:
1005-202X（2022）11-1345-04
作者:
江承川1; 李茉莉2; 刘莎1; 朱中山1; 李小兵1
1.湖南省脑科医院（湖南省第二人民医院）肿瘤科， 湖南 长沙 410007； 2.郴州市第一人民医院呼吸与危重症医学科， 湖南 郴州 423000
Author(s):
JIANG Chengchuan1;  LI Moli2;  LIU Sha1;  ZHU Zhongshan1;  LI Xiaobing1
1. Department of Oncology, Hunan Brain Hospital (the Second Peoples Hospital of Hunan Province), Changsha 410007, China 2. Department of Respiratory and Critical Care Medicine, Chenzhou No.1?eoples Hospital, Chenzhou 423000, China
关键词:
局部晚期肺癌; 调强放射治疗; 药物治疗; 生存期; 毒副反应
Keywords:
Keywords: locally advanced lung cancer intensity-modulated radiotherapy medication survival time toxic and side effect
分类号:
R816.41
DOI:
DOI:10.3969/j.issn.1005-202X.2022.11.005
文献标志码:
A
摘要:
目的：探讨不同剂量调强放疗联合同步化疗对局部晚期肺癌患者生存期和毒副反应的影响。方法：选取96例确诊为局部晚期肺癌患者为研究对象，随机分为对照组（n=48）和观察组（n=48）。对照组采用62 Gy调强放疗联合PC同步化疗，观察组调整放疗剂量为50 Gy。记录患者临床一般资料。K-M分析绘制生存曲线，Log Rank [χ2]检验比较生存率，记录两组患者治疗1个月后毒副反应发生情况。结果：观察组和对照组患者缓解率无显著差异（75.00% vs79.17%, P>0.05）；观察组患者总生存率和无进展生存率均高于对照组（P<0.05），中位生存时间显著长于对照组（P<0.05）。观察组骨髓抑制和放射性肺炎等放疗毒副反应发生率显著低于对照组（P<0.05）。结论：通过降低调强放疗剂量能够减轻患者毒副反应，提高患者生存期，联合同步化疗能够发挥良好的临床缓解效应。
Abstract:
Abstract: Objective To explore the effects of different doses of intensity-modulated radiotherapy (IMRT) combined with concurrent chemotherapy on survival and toxicity in patients with locally advanced lung cancer. Methods A total of 96 patients with locally advanced lung cancer were randomly divided into control group (n=48) and observation group (n=48). The control group was treated with IMRT (62 Gy) and concurrent PC chemotherapy, while the IMRT dose in observation group was 50 Gy. The general clinical data of patients were recorded. The survival curves were drawn using K-M analysis, and the survival rates were compared using Log Rank [χ2] test. The incidence of radiation-induced toxicity in 1 month after treatment was recorded. Results The remission rate in observation group was 75.00%, close to 79.17% in control group (P>0.05). The overall survival rate and progression-free survival rate in observation group were higher than those in control group (P<0.05), and the median survival time was significantly longer than that in control group (P<0.05). The incidences of radiation-induced toxicity such as bone marrow suppression and radiation pneumonitis in observation group were significantly lower than those in control group (P<0.05). Conclusion Reducing IMRT dose can relieve radiation-induced toxicity and prolong survival in patients. IMRT combined with concurrent chemotherapy can cause favorable clinical remission.

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备注/Memo

备注/Memo:
【收稿日期】2022-05-17 【基金项目】湖南省卫生健康委科研计划（B2019048） 【作者简介】江承川，副主任医师，研究方向：肺癌的治疗，E-mail: bxk69005@163.com 【通信作者】李茉莉，E-mail: zj8006@aliyun.com
更新日期/Last Update: 2022-11-25