多电极联合电刺激神经调控模型建立与分析-《中国医学物理学杂志》

文章信息/Info

Title:: Establishment and analysis of neuromodulation model based on multiple-electrode electrical stimulation

作者:: 张双1; 2; 3; 余远昱1; 王久江1; 徐晶1; 旷江明1; 杨济宁1; 张涛2; 3; 1.内江师范学院人工智能学院，四川内江 641112； 2.电子科技大学生命科学与技术学院，四川成都 611731； 3.电子科技大学高场磁共振脑成像四川省重点实验室，四川成都 611731

Author(s):: ZHANG Shuang1; 2; 3; YU Yuanyu1; WANG Jiujiang1; XU Jing1; KUANG Jiangming1; YANG Jining1; ZHANG Tao2; 3; 1.School of Artificial Intelligence, Neijiang Normal University, Neijiang 641112, China 2. School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China 3. Sichuan Key Laboratory of High-Field Magnetic Resonance Brain Imaging, University of Electronic Science and Technology of China, Chengdu 611731, China

Keywords:: Keywords: transcranial electrical stimulation multiple-electrode electrical stimulation single-layer human head model neuromodulation finite element model

摘要:: 目的：分析电刺激信号在人体组织中的扩散情况，为多电极联合刺激提供理论依据。方法：采用以电磁仿真标准单层人体头部模型为研究对象的几何结构模型，假定模型中填充物为肌肉组织，建立具有肌肉特性的有限元模型。向模型注入20 mA的直流电信号，通过多物理场仿真软件COMSOL Multiphysics 5.5计算分析信号在简化头部模型中的信号传播机制。结果：信号主要集中在电极周围；多电极联合刺激时，在模型的几何中心处存在信号叠加，信号在该处存在增强的趋势；同时，通过xy截面分析发现，在均匀的肌肉组织中，信号衰减强度约为8 dB/cm。结论：在简化头部模型中，多电极联合刺激能够在头部截面几何中心形成信号增强的趋势。

Abstract:: Abstract: Objective To analyze the diffusion of electrical stimulation signal in human tissues, thereby providing theoretical basis for multiple-electrode electrical stimulation. Methods A geometric structure model with the standard single-layer human head model in the electromagnetic simulation as the research object was adopted in the study. Assuming that the filler in the model was muscle tissues, a finite element model with muscle characteristics was established. Then, DC electrical signal of 20 mA was input to the model, and the signal transmission mechanism in the simplified head model was computed and analyzed by the multi-physics field simulation software COMSOL Multiphysics 5.5. Results The signal was mainly concentrated around the electrode. When using multi-electrode electrical stimulation, there was signal superposition at the geometric center of the model, and the signal at here had a trend of enhancement. Meanwhile, it was found through analysis on xy cross-section that in a homogeneous muscle tissue, the signal attenuation intensity was about 8 dB/cm. Conclusion In the simplified head model, multi-electrode electrical stimulation can form a signal enhancement trend at the geometric center of the cross-section of the head.