[1]薛彩强,李昇霖,刘显旺,等.MRI征象及ADC值鉴别成人颅内髓母细胞瘤与室管膜瘤的价值[J].中国医学物理学杂志,2022,39(10):1244-1249.[doi:DOI:10.3969/j.issn.1005-202X.2022.10.011]
　XUE Caiqiang,,et al.Differentiating adult intracranial medulloblastoma and ependymoma using MRI signs and ADC[J].Chinese Journal of Medical Physics,2022,39(10):1244-1249.[doi:DOI:10.3969/j.issn.1005-202X.2022.10.011]
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MRI征象及ADC值鉴别成人颅内髓母细胞瘤与室管膜瘤的价值()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第10期
页码:
1244-1249
栏目:
医学影像物理
出版日期:
2022-11-02

文章信息/Info

Title:
Differentiating adult intracranial medulloblastoma and ependymoma using MRI signs and ADC
文章编号:
1005-202X（2022）10-1244-06
作者:
薛彩强1; 2; 3; 4; 李昇霖1; 2; 3; 4; 刘显旺1; 2; 3; 4; 邓娟1; 2; 3; 4; 周俊林1; 2; 3; 4
1.兰州大学第二医院放射科， 甘肃 兰州 730030； 2.兰州大学第二临床医学院， 甘肃 兰州 730030； 3.甘肃省医学影像重点实验室， 甘肃 兰州 730030； 4.医学影像人工智能甘肃省国际科技合作基地， 甘肃 兰州 730030
Author(s):
XUE Caiqiang1;  2;  3;  4;  LI Shenglin1;  2;  3;  4;  LIU Xianwang1;  2;  3;  4;  DENG Juan1;  2;  3;  4;  ZHOU Junlin1;  2;  3;  4
1. Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China 2. The Second Clinical Medical School, Lanzhou University, Lanzhou 730030, China 3. Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China 4. Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, Lanzhou 730030, China
关键词:
髓母细胞瘤; 室管膜瘤; 磁共振成像; 表观扩散系数
Keywords:
Keywords: medulloblastoma ependymoma magnetic resonance imaging apparent diffusion coefficient
分类号:
R739.41；R816.1
DOI:
DOI:10.3969/j.issn.1005-202X.2022.10.011
文献标志码:
A
摘要:
目的：探索磁共振成像（MRI）征象及表观扩散系数（ADC）值在鉴别成人颅内髓母细胞瘤与室管膜瘤中的价值。方法：回顾性分析手术及病理证实的16例成人颅内髓母细胞瘤及24例室管膜瘤临床、MRI及病理资料，对比MRI征象及ADC值差异，使用受试者工作特征（ROC）曲线评估ADC值在两组肿瘤鉴别诊断中的效能。结果：成人髓母细胞瘤与室管膜瘤在年龄、肿瘤位置和强化程度比较差异有统计学意义（P<0.05），两组患者性别、形态、肿瘤边界、囊变、瘤周水肿、肿瘤最大径、水肿最大径等比较差异无统计学意义（P>0.05）；成人室管膜瘤ADCmean、ADCmin及rADC值均大于成人髓母细胞瘤，差异有统计学意义（P<0.05）。ADCmean阈值为665.00 mm2/s时，鉴别诊断成人髓母细胞瘤与室管膜瘤的性能最佳，AUC值为0.966，敏感度和特异度分别为0.958、0.937。结论：通过MRI征象联合ADC值对术前鉴别成人髓母细胞瘤与室管膜瘤具有重要的临床价值，有助于辅助临床术前制定个性化诊疗方案。
Abstract:
Abstract: Objective To explore the value of MRI signs and apparent diffusion coefficient (ADC) in differentiating adult intracranial medulloblastoma from ependymoma. Methods The clinical, MRI and pathological data of 16 adults with intracranial medulloblastoma and 24 with ependymoma confirmed by surgery and pathology were retrospectively analyzed.The differences between two groups in MRI signs and ADC values ?#8203were compared, and receiver operating characteristic curve was used to assess the diagnostic efficacy of ADC values in the differentiation of adult intracranial medulloblastoma and ependymoma. Results There were statistically significant differences between adult medulloblastoma and ependymoma in age, tumor location and degree of enhancement (P<0.05), but not in gender, morphology, tumor boundary, cystic degeneration, peritumoral edema, maximum diameter of the tumor, and maximum diameter of edema (P>0.05). The ADCmean, ADCmin and rADC values ?#8203of adult ependymoma were greater than those of adult medulloblastoma, and the differences were statistically significant (P<0.05). When the ADCmean threshold was 665.00 mm2/s, it had the best performance for the differential diagnosis of adult medulloblastoma and ependymoma, with an AUC of 0.966, and its sensitivity and specificity were 0.958 and 0.937, respectively. Conclusion The combination of MRI signs and ADC has important clinical value for the preoperative differentiation of adult medulloblastoma and ependymoma, and it is helpful to assist the formulation of preoperative personalized diagnosis and treatment scheme.

备注/Memo

备注/Memo:
【收稿日期】2022-02-19 【基金项目】国家自然科学基金（82071872）；兰州大学中央高校基本科研业务费专项资金资助（lzujbky-2021-kb32） 【作者简介】薛彩强，在读博士，研究方向：中枢神经系统肿瘤，E-mail: 1102599617@qq.com 【通信作者】周俊林，博士，主任医师，研究方向：神经影像学，E-mail: lzuzjl601@163.com
更新日期/Last Update: 2022-10-27