[1]张扬琼,杨华君,罗日顺,等.不同放射治疗技术对全脑全脊髓放疗患者血液学毒性的影响[J].中国医学物理学杂志,2022,39(7):805-810.[doi:DOI:10.3969/j.issn.1005-202X.2022.07.003]
　ZHANG Yangqiong,YANG Huajun,LUO Rishun,et al.Effect of different radiotherapy techniques on hematological toxicity of craniospinal irradiation[J].Chinese Journal of Medical Physics,2022,39(7):805-810.[doi:DOI:10.3969/j.issn.1005-202X.2022.07.003]
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不同放射治疗技术对全脑全脊髓放疗患者血液学毒性的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第7期
页码:
805-810
栏目:
医学放射物理
出版日期:
2022-07-15

文章信息/Info

Title:
Effect of different radiotherapy techniques on hematological toxicity of craniospinal irradiation
文章编号:
1005-202X（2022）07-0805-06
作者:
张扬琼; 杨华君; 罗日顺; 邓官华; 张平; 蔡林波
广东三九脑科医院肿瘤综合治疗中心， 广东 广州 510510
Author(s):
ZHANG Yangqiong;  YANG Huajun;  LUO Rishun;  DENG Guanhua;  ZHANG Ping;  CAI Linbo
Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China
关键词:
全脑全脊髓放疗; 三维适形放疗; 调强放疗; 血液学毒性; 骨髓抑制
Keywords:
Keywords: craniospinal irradiation three-dimensional conformal radiotherapy intensity-modulated radiotherapy hematological toxicity bone marrow suppression
分类号:
R815
DOI:
DOI:10.3969/j.issn.1005-202X.2022.07.003
文献标志码:
A
摘要:
目的：探讨不同放疗技术对全脑全脊髓放疗患者血象的影响。方法：回顾性分析79例行全脑全脊髓放疗患者的血象变化，其中观察组36例行调强放疗，对照组43例行三维适形放疗。两组患者靶区处方剂量为28.8~36.0 Gy，单次剂量为1.6~2.0 Gy，记录两组患者在放疗前、中、后血液学毒性变化和骨髓抑制程度，采用非参数Mann-Whitney U检验比较组间差异。结果：90%的病人在放疗期间以及放疗后出现不同程度的骨髓抑制，观察组在放疗期间血红蛋白以及放疗结束后2周血红蛋白和白细胞的抑制程度较对照组严重（z=-2.272, P=0.023；z=-3.053, P=0.002；z=-3.163, P=0.002）。结论：采用调强技术行全脑全脊髓放疗时，应密切观察患者血象变化并采取相应防治措施，避免调强放疗导致的严重骨髓抑制的发生。
Abstract:
Abstract: Objective To investigate the effect of different radiotherapy techniques on hematological toxicity of craniospinal irradiation. Methods A retrospective study involving changes in hematology during craniospinal irradiation was conducted on 79 patients who were treated by craniospinal irradiation. The 36 patients in observation group received intensity-modulated radiotherapy, and 43 patients in control group underwent three-dimensional conformal radiotherapy.The prescribed dose of PTV in the two groups was 28.8-36.0 Gy, with 1.6-2.0 Gy each fraction. The hematological toxicity changes and bone marrow suppression stage of the two groups of patients before, during and after radiotherapy were recorded and analyzed. Results 90% of patients had different bone marrow suppression stages during and after radiotherapy. During radiotherapy, the toxicity of hemoglobin in observation group was more serious than that in the control group (z=-2.272, P=0.023).After radiotherapy, the toxicity of hemoglobin and white blood cells in observation group was more serious than those in control group (z=-3.053, P=0.002 z=-3.163, P=0.002). Conclusion The changes of hematological toxicity for craniospinal irradiation patient treated with IMRT should be closely observed compared with 3DCRT, and the corresponding preventive measures should be taken to avoid serious bone marrow suppression.

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备注/Memo

备注/Memo:
【收稿日期】2022-01-21 【基金项目】广东省科技计划项目（2017ZC0418） 【作者简介】张扬琼，主管护师，研究方向：神经肿瘤的综合护理，E-mail: 190124683@qq.com 【通信作者】蔡林波，硕士，主任医师，研究方向：神经肿瘤的综合治疗，E-mail: cailinbo999@163.com
更新日期/Last Update: 2022-07-15