[1]贾润慧,汪新柱,陈晓飞,等.下腰痛患者脑网络的动态功能连接[J].中国医学物理学杂志,2021,38(9):1084-1089.[doi:10.3969/j.issn.1005-202X.2021.09.007]
　JIA Runhui,WANG Xinzhu,CHEN Xiaofei,et al.Dynamic functional connectivity of brain networks in patients with low back pain[J].Chinese Journal of Medical Physics,2021,38(9):1084-1089.[doi:10.3969/j.issn.1005-202X.2021.09.007]
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下腰痛患者脑网络的动态功能连接()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第9期
页码:
1084-1089
栏目:
医学影像物理
出版日期:
2021-09-26

文章信息/Info

Title:
Dynamic functional connectivity of brain networks in patients with low back pain
文章编号:
1005-202X（2021）09-1084-06
作者:
贾润慧1; 汪新柱1; 陈晓飞1; 董馥闻1; 周晟1; 俞连春2; 陈祁青3
1. 甘肃省中医院放射影像科，甘肃兰州730050；2. 兰州大学物理科学与技术学院，甘肃兰州730000；3. 甘肃省中医院脊柱骨科， 甘肃兰州730050
Author(s):
JIA Runhui1;  WANG Xinzhu1;  CHEN Xiaofei1;  DONG Fuwen1;  ZHOU Sheng1;  YU Lianchun2;  CHEN Qiqing3
1. Department of Radiology, Gansu Provincial Hospital of TCM, Lanzhou 730050, China 2. School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China 3. Department of Orthopaedic Spine, Gansu Provincial Hospital of TCM, Lanzhou 730050, China
关键词:
下腰痛; 磁共振成像; 动态功能连接; 功能灵活性
Keywords:
low back pain magnetic resonance imaging dynamic functional connectivity functional flexibility
分类号:
R445.2；R318
DOI:
10.3969/j.issn.1005-202X.2021.09.007
文献标志码:
A
摘要:
目的：探究下腰痛（LBP）患者脑网络功能连接的动态变化。方法：对20例LBP患者及20例健康志愿者进行静息态 脑功能核磁共振扫描，采用连接数目熵（CNE）比较LBP患者与健康志愿者大脑的动态功能连接变化，分析LBP患者各独立 脑区的功能灵活性与年龄和日本骨科协会（JOA）量表评分的相关性。结果：全脑水平，LBP患者CNE低于正常人（P＜0.05）， 显著改变的脑区集中在额叶皮层、颞叶皮层、皮质下核团及部分枕叶皮层。脑区水平，LBP 患者中AAL 15（r=-0.525 5, P=0.020 8）、AAL32（r=-0.529 2,P=0.019 8）、AAL41（r=-0.546 9,P=0.015 4）、AAL62（r=0.601 5,P=0.006 4）、AAL76（r=-0.513 3, P=0.024 6）、AAL89（r=0.461 9, P=0.046 5）和AAL90（r=0.508 5, P=0.026 2）与年龄有临床相关性。LBP患者AAL17（r=-0.499 1, P=0.029 6）、AAL 47（r=0.481 4, P=0.036 9）、AAL 82（r=-0.554 8, P=0.013 7）、AAL 90（r=-0.562 1, P=0.012 3）与临床JOA量 表评分有相关性。结论：LBP患者全脑功能网络的功能灵活性是降低的。CNE动态功能连接的测量不仅为量化大脑活动 的时间与空间行为提供了一个新的框架，而且可以探索LBP脑功能变化的机理。
Abstract:
Objective To explore the dynamic functional connectivity of brain networks in low back pain (LBP) patients. Methods The resting-state functional magnetic resonance imaging was performed on 20 LBP patients and 20 normal controls. The dynamic functional connectivity between LBP patients and normal controls was compared using connectivity number entropy (CNE), and the correlations between functional flexibility of each independent brain region in LBP patients and age and JOA scale score were also analyzed. Results The CNE of LBP patients was lower than that of normal controls at the whole brain level (P<0.05), and the brain regions with significant changes were concentrated in frontal cortex, temporal cortex, subcortical nucleus mass and part of occipital cortex. Locally, some brain regions such asAAL15 (r=-0.525 5, P=0.020 8),AAL32 (r=-0.529 2, P=0.019 8),AAL41 (r=-0.546 9, P=0.015 4), AAL 62 (r=0.601 5, P=0.006 4), AAL 76 (r=-0.513 3, P=0.024 6), AAL 89 (r=0.461 9, P=0.046 5) and AAL90 (r=0.508 5, P=0.026 2) had clinical relevance to age, and others brain regions, includingAAL17 (r=-0.499 1, P=0.029 6), AAL 47 (r=0.481 4, P=0.036 9), AAL 82 (r=-0.554 8, P=0.013 7) and AAL 90 (r=-0.562 1, P=0.012 3), were correlated with JOA scale score. Conclusion The functional flexibility of brain networks in LBP patients is reduced at the whole brain level. The measurement of CNE for evaluating dynamic functional connectivity not only provides a new framework for quantifying spatial and temporal behaviors of brain activity, but also can be used to explore the mechanism of brain function changes in LBP patients.

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备注/Memo

备注/Memo:
【收稿日期】2021-03-23 【基金项目】国家自然科学基金（81760877）；甘肃省青年科技基金 （17JR5RA049） 【作者简介】贾润慧，副主任医师，研究方向：脑功能磁共振成像，Email: jrhlzh@163.com 【通信作者】周晟，研究生导师，主任医师，研究方向：针灸影像学，E-mail: lzzs@sina.com
更新日期/Last Update: 2021-09-27