[1]沈建军,牛维纳,闫冰,等.应用4DCT测量老年食管癌患者放疗引发的肺通气功能变化[J].中国医学物理学杂志,2021,38(3):277-280.[doi:DOI:10.3969/j.issn.1005-202X.2021.03.002]
　SHEN Jianjun,NIU Weina,YAN Bing,et al.Measurement of pulmonary ventilation in elderly patients with esophageal cancer by 4DCT[J].Chinese Journal of Medical Physics,2021,38(3):277-280.[doi:DOI:10.3969/j.issn.1005-202X.2021.03.002]
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应用4DCT测量老年食管癌患者放疗引发的肺通气功能变化()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第3期
页码:
277-280
栏目:
医学放射物理
出版日期:
2021-03-30

文章信息/Info

Title:
Measurement of pulmonary ventilation in elderly patients with esophageal cancer by 4DCT
文章编号:
1005-202X（2021）03-0277-04
作者:
沈建军; 牛维纳; 闫冰; 余枭; 解远
中国科学技术大学附属第一医院（安徽省立医院）肿瘤放疗科， 安徽 合肥 230001
Author(s):
SHEN Jianjun;  NIU Weina;  YAN Bing;  YU Xiao;  XIE Yuan
Department of Radiation Oncology, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, China
关键词:
食管癌; 四维计算机断层扫描; 放射治疗; 肺功能
Keywords:
Keywords: esophageal cancer four-dimensional computed tomography radiotherapy pulmonary function
分类号:
R459.2；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2021.03.002
文献标志码:
A
摘要:
目的：评价4DCT检测75岁及以上食管癌患者放疗前后的肺通气功能。方法：纳入31例符合条件的75岁及以上高龄食管癌患者。4DCT扫描图像经过形变配准后进行几何二等分。制定3个肺通气功能分析指标：上下肺通气比值，左右肺通气比值和前后肺通气比值。结果：伴有慢性阻塞性肺疾病（COPD）组与无COPD组的上下肺通气比值差异有统计学意义（P<0.05），前后肺通气比值及左右肺通气比值未见明显差异。在75~80岁组与≥80岁组只发现上下肺通气比值差异有统计学意义（P<0.05）。放疗后在COPD组与无COPD组中发现上下肺通气比值（P<0.05）及前后肺通气比值（P<0.05）均有明显差异。放疗后75~80岁组与≥80岁组的上下肺通气比值有统计学差异（P<0.05）。放疗期间同步化疗组与未同步化疗组在肺通气功能上未见明显差别。结论：应用4DCT扫描可区别放疗前后的肺通气功能变化，为早期临床干预提供可能。
Abstract:
Abstract: Objective To use four-dimensional computed tomography (4DCT) for evaluating the pulmonary ventilation in esophageal cancer patients aged 75 years and over. Methods Thirty-one esophageal cancer patients aged 75 years and over were enrolled in the study. 4DCT images were dichotomized by geometry after deformation. The pulmonary ventilation function was evaluated by 3 indexes, namely superior-inferior pulmonary ventilation ratio, left-right pulmonary ventilation ratio and anterior-posterior pulmonary ventilation ratio. Results There was significant difference between chronic obstructive pulmonary disease (COPD) group and non-COPD group in superior-inferior pulmonary ventilation ratio (P<0.05), but not in anterior-posterior pulmonary ventilation ratio and left-right pulmonary ventilation ratio. Moreover, significant difference was only found in superior-inferior pulmonary ventilation ratio between patients aged 75-80 years and those aged 80 years and over (P<0.05). After radiotherapy, there were significant differences between COPD group and non-COPD group in superior-inferior pulmonary ventilation ratio (P<0.05) and anterior-posterior pulmonary ventilation ratio (P<0.05), and the superior-inferior pulmonary ventilation ratio in patients aged 75-80 years was significantly different from that in those aged 80 years and over (P<0.05). During radiotherapy, the pulmonary ventilation function in chemoradiotherapy group was similar to that in non-concurrent chemotherapy group. Conclusion 4DCT can be used to detect the variations of pulmonary ventilation function before and after radiotherapy, providing the possibility for the early clinical intervention.

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备注/Memo

备注/Memo:
【收稿日期】2020-12-25 【基金项目】中央高校基本科研业务费专项（WK9110000106） 【作者简介】沈建军，主治医师，研究方向：肿瘤放射治疗，E-mail: takemeparadise@163.com 【通信作者】闫冰，高级工程师，研究方向：肿瘤放射物理，E-mail: cpreo@126.com
更新日期/Last Update: 2021-03-30