[1]李春龙,江桂华,马晓芬,等.慢性失眠患者大脑蓝斑的异常静息态功能连接[J].中国医学物理学杂志,2021,38(6):699-703.[doi:DOI:10.3969/j.issn.1005-202X.2021.06.008]
　LI Chunlong,JIANG Guihua,MA Xiaofen,et al.Abnormal resting-state functional connectivity of the locus coeruleus in patients with chronic insomnia[J].Chinese Journal of Medical Physics,2021,38(6):699-703.[doi:DOI:10.3969/j.issn.1005-202X.2021.06.008]
点击复制

慢性失眠患者大脑蓝斑的异常静息态功能连接()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第6期
页码:
699-703
栏目:
医学影像物理
出版日期:
2021-06-29

文章信息/Info

Title:
Abnormal resting-state functional connectivity of the locus coeruleus in patients with chronic insomnia
文章编号:
1005-202X（2021）06-0699-05
作者:
李春龙1; 江桂华1; 2; 马晓芬2; 李淑美2; 蓝智鸿2; 黄淑梅1
1.广东医科大学第一临床医学院， 广东 湛江 524023； 2.广东省第二人民医院影像科， 广东 广州 510317
Author(s):
LI Chunlong1;  JIANG Guihua1; 2;  MA Xiaofen2;  LI Shumei2;  LAN Zhihong2;  HUANG Shumei1
1. the First Clinical Medical College, Guangdong Medical University, Zhanjiang 524023, China 2. Department of Imaging, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
关键词:
慢性失眠; 蓝斑; 默认模式网络; 静息态功能连接
Keywords:
Keywords: chronic insomnia locus coeruleus default mode network resting-state functional connectivity
分类号:
R318；R445.2
DOI:
DOI:10.3969/j.issn.1005-202X.2021.06.008
文献标志码:
A
摘要:
目的：利用功能连接方法观察慢性失眠患者静息态下蓝斑的异常功能连接。方法：采集49例慢性失眠患者以及47例性别年龄和受教育程度相匹配的健康对照组的功能磁共振图像，以蓝斑为感兴趣区域，与全脑其他体素进行功能连接分析，得到两组之间功能连接的差异脑区，再对异常连接脑区的功能连接值与临床量表分数做相关分析。结果：与对照组相比，慢性失眠患者蓝斑与右楔前叶皮质、右后扣带回皮质、左颞中回皮质、左距状沟周围皮质、右眶部额上回皮质之间的功能连接增强（P<0.05, FDR校正），并且蓝斑与左颞中回皮质之间功能连接值与抑郁自评量表呈正相关（P=0.021）。结论：慢性失眠患者蓝斑与多个脑区（主要是默认模式网络）出现的异常功能连接，可能有助于更好地理解慢性失眠的神经生物学机制，可能为失眠的高度唤醒假说提供新的影像学证据。
Abstract:
Abstract: Objective To investigate the abnormal resting-state functional connectivity of the locus coeruleus in patients with chronic insomnia using functional connectivity analysis. Methods A total of 49 patients with chronic insomnia and 47 gender-, age- and education-matched healthy controls were examined with resting-state functional magnetic resonance imaging (fMRI) in the study. The locus coeruleus in fMRI image was selected as the region of interest, and then functional connectivity analysis was conducted on the locus coeruleus and other voxels in the brain for obtaining the brain regions with different functional connectivity between two groups. The correlation between the functional connectivity value of the brain region with abnormal functional connectivity and clinical scale score was also analyzed. Results Compared with that in control group, the functional connectivity between the locus coeruleus and multiple brain regions (including right precuneus, right posterior cingulate cortex, left middle temporal gyrus, left calcarine periphery cortex and right superior orbitofrontal cortex) was significantly enhanced (P<0.05, FDR correction), and the functional connectivity value between the locus coeruleus and left middle temporal gyrus was positively correlated with the score of self-rating depression scale (P=0.021). Conclusion The abnormal functional connectivity between the locus coeruleus and multiple brain regions (mainly default mode network) in patients with chronic insomnia may contribute to understanding the neurobiological mechanism of chronic insomnia, and may provide new imaging evidence for the high arousal hypothesis of insomnia.

备注/Memo

备注/Memo:
【收稿日期】2021-02-15 【基金项目】国家自然科学基金联合申报培育项目（U1903120）；广州市科技计划项目（202002030234） 【作者简介】李春龙，硕士研究生，研究方向：脑功能磁共振，E-mail: 960559619@qq.com 【通信作者】江桂华，博士，教授，研究方向：中枢神经系统影像，E-mail: 13828472201@163.com
更新日期/Last Update: 2021-06-29