[1]张光玉,徐龙春,张敏风,等.听视觉刺激对长期听力损失患者语言处理的影响[J].中国医学物理学杂志,2021,38(2):228-232.[doi:DOI:10.3969/j.issn.1005-202X.2021.02.018]
　ZHANG Guangyu,XU Longchun,ZHANG Minfeng,et al.Effects of auditory and visual stimuli on speech processing of patients with long-term hearing loss[J].Chinese Journal of Medical Physics,2021,38(2):228-232.[doi:DOI:10.3969/j.issn.1005-202X.2021.02.018]
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听视觉刺激对长期听力损失患者语言处理的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第2期
页码:
228-232
栏目:
医学信号处理与医学仪器
出版日期:
2021-02-02

文章信息/Info

Title:
Effects of auditory and visual stimuli on speech processing of patients with long-term hearing loss
文章编号:
1005-202X（2021）02-0228-05
作者:
张光玉1; 徐龙春2; 张敏风2; 张岗2; 邹越2; 程运福1; 何乐民1; 赵文波2; 刘怡颖1; 王晓艳1; 王鹏程1
1.山东第一医科大学（山东省医学科学院）放射学院， 山东 泰安271016； 2.山东第一医科大学（山东省医学科学院）第二附属医院， 山东 泰安271000
Author(s):
ZHANG Guangyu1;  XU Longchun2;  ZHANG Minfeng2;  ZHANG Gang2;  ZOU Yue2;  CHENG Yunfu1;  HE Lemin1;  ZHAO Wenbo2;  LIU Yiying1;  WANG Xiaoyan1;  WANG Pengcheng1
1. Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, China 2. the Second Affiliated Hospital of Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271000, China
关键词:
听视觉重组; 最短因果连接路径; 听视觉抑制; 虚拟数字脑; 双侧听力损失; 语言处理
Keywords:
Keywords: auditory-visual reorganization the shortest causal connectivity path auditory-visual inhibition virtual digital brain bilateral hearing loss speech processing
分类号:
R318；TP391.4
DOI:
DOI:10.3969/j.issn.1005-202X.2021.02.018
文献标志码:
A
摘要:
目的：研究听视觉刺激对听力损失患者大脑中与语言处理相关脑区神经活动的影响，为患者的康复治疗提供理论支撑。方法：募集12个听力损失患者和12个性别年龄匹配的正常听力受试者。首先构建每个参与者个体化虚拟数字脑，然后将虚拟视觉刺激信号施加到已构建虚拟数字脑的次级视觉皮层；将虚拟听觉刺激信号施加到已构建虚拟数字脑的初级听觉皮层。最后，观察这些刺激信号在听力损失患者脑皮层中所诱发的神经活动变化。结果：同正常受试者相比，虚拟视觉刺激信号抑制了听力损失患者听觉皮层和布洛卡区的神经活动，并通过最短因果路径削弱了布洛卡区的激活。相反，虚拟听觉刺激信号抑制了听力损失患者视觉皮层的激活，但通过最短因果路径增强了布洛卡区的神经活动。此外，听力损失患者也呈现了减弱的视觉诱发的威尼克区的激活。结论：目前的研究表明，视觉刺激通过削弱听觉皮层和布洛卡区的神经活动抑制了听力损失患者的语言处理。相反，听觉刺激通过抑制视觉皮层的活动,增强布洛卡区的神经活动，从而改善了听力损失患者的语言处理。
Abstract:
Abstract: Objective To research the effects of auditory and visual stimuli on the neural activities of cerebral cortices associated with speech processing in patients with hearing loss (HL), thereby providing theoretical support for the rehabilitation treatment of HL patients. Methods Twelve patients with long-term bilateral HL and 12 gender- and age-matched normal-hearing controls were enrolled in the study. The individual virtual digital brain of each subject was firstly constructed. Then a stimulating signal of visual task was processed and then exerted to the secondary visual cortex of the constructed virtual digital brain. Similarly, a stimulating signal of auditory task was also processed and then exerted to the primary auditory cortex of the constructed virtual digital brain. Finally, the changes of brain region activations evoked by these stimulating signals in HL patients were observed. Results The visual stimulus inhibited the neural activities of auditory cortex and Brocas area, and through the shortest causal connectivity paths, further weakened the activation of Brocas area in HL patients compared with normal-hearing controls. In contrast, the auditory stimulus inhibited the activation of visual cortex in HL patients, but enhanced their neural activity of Brocas area through the shortest synchronous causal connectivity paths. Additionally, compared with normal-hearing controls, HL patients presented weaker visual-evoked activation in Wernickes area. Conclusion The findings suggest that the visual stimulus limits the HL patients capacity of speech processing through inhibiting the neural activities of auditory cortex and Brocas area, and that the auditory stimulus improves the HL patients capacity of speech processing through inhibiting the activation of visual cortex and enhancing the neural activity of Brocas area.

备注/Memo

备注/Memo:
【收稿日期】2020-10-15 【基金项目】山东省自然科学基金（ZR2018MH033, ZR2015HL095, ZR2014HM072）；山东省医药卫生科技发展计划（2016WS0608）；泰山医学院高层次课题培育计划（2018GCC13）；山东第一医科大学学术提升计划（2019LJ004） 【作者简介】张光玉，副教授，主要从事医学图像处理、脑功能成像和虚拟数字脑方面的研究，E-mail: gyuzhn@163.com
更新日期/Last Update: 2021-02-04