[1]李赓,高健全.EB病毒DNA检测在鼻咽癌IMRT疗效分析中的价值[J].中国医学物理学杂志,2020,37(12):1502-1505.[doi:DOI:10.3969/j.issn.1005-202X.2020.12.006]
　LI Geng,GAO Jianquan.Value of DNA detection of Epstein Barr virus in the analysis of curative effect of intensity-modulated radiation therapy for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2020,37(12):1502-1505.[doi:DOI:10.3969/j.issn.1005-202X.2020.12.006]
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EB病毒DNA检测在鼻咽癌IMRT疗效分析中的价值()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第12期
页码:
1502-1505
栏目:
医学放射物理
出版日期:
2020-12-30

文章信息/Info

Title:
Value of DNA detection of Epstein Barr virus in the analysis of curative effect of intensity-modulated radiation therapy for nasopharyngeal carcinoma
文章编号:
1005-202X（2020）12-1502-04
作者:
李赓; 高健全
梧州市红十字会医院放疗三区， 广西 梧州 543000
Author(s):
LI Geng;  GAO Jianquan
Radiotherapy Zone 3, Wuzhou Red Cross Hospital, Wuzhou 543000, China
关键词:
鼻咽癌; EB病毒; DNA检测; 调强放射治疗
Keywords:
Keywords: nasopharyngeal carcinoma EB virus DNA detection intensity-modulated radiation therapy
分类号:
R739.6；R816.96
DOI:
DOI:10.3969/j.issn.1005-202X.2020.12.006
文献标志码:
A
摘要:
目的：探讨EB病毒DNA检测在鼻咽癌调强放射治疗（IMRT）疗效分析中的价值。方法：选取梧州市红十字会医院肿瘤科放疗三区接受治疗的50例鼻咽癌患者为研究对象，对其予IMRT放疗，分别在放疗前、中、结束后即刻以及放疗后第6、9、12、18个月时复查患者外周血标本，采用荧光定量PCR法检测EB病毒DNA，分析其与鼻咽癌近期疗效、总生存率（OS）、无进展生存期（PFS）、无病生存率（DFS）、无复发生存率（RFS）的关系。结果：随着患者接受放疗至随访结束，DNA阳性率从放疗前的63.2%、放疗中的30.1%、放疗后即时10.6%一直下降至放疗后18个月复查时的5.35%，可见其随时间呈下降趋势，而这一结果与它的近期疗效评价及生存分析中OS、PFS、DFS、RFS结果一致。结论：可以通过检测鼻咽癌患者EB病毒DNA了解放疗疗效并进行预后评估。
Abstract:
Abstract: Objective To explore the value of DNA detection of Epstein Barr (EB) virus in the analysis of curative effect of intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma. Methods 50 nasopharyngeal carcinoma patients who were treated in the radiotherapy zone 3 of the oncology department of Wuzhou Red Cross Hospital were selected as the research objects and were treated with IMRT radiotherapy. Their peripheral blood samples were tested before, during, and immediately after the radiotherapy and were retested in six, nine, twelve, and eighteen months after the radiotherapy. Based on the DNA detection of EB virus by fluorescence quantitative PCR, the relationship between EB virus DNA concentration and short-term efficacy of nasopharyngeal carcinoma, overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), recurrence-free survival (RFS) was analyzed. Results From the patients receiving radiotherapy to the end of follow-up, the positive rate of DNA decreased from 63.2% (before the radiotherapy), 30.1% (during radiotherapy) and 10.6% (immediately after radiotherapy) to 5.35% in the reexamination when 18 months after radiotherapy, showing a downward trend over time. This result was consistent with OS, PFS, DF and RFS in recent efficacy evaluation and survival analysis. Conclusion The efficacy of liberation therapy and prognosis can be determined and evaluated by detecting the DNA of EB virus in patients with nasopharyngeal carcinoma.

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备注/Memo

备注/Memo:
【收稿日期】2020-08-21 【基金项目】广西壮族自治区卫生和计划生育委员会科研课题（Z2017- 0645）；梧州市科技计划项目（201902154） 【作者简介】李赓，主治医师，E-mail: 451033790@qq.com 【通信作者】高健全，主任医师，E-mail: gjq2369712@sina.com
更新日期/Last Update: 2020-12-30