[1]张翠翠,卢晓军,赵静.3种剂量三维适形放疗对Ⅲ期食管癌患者的疗效与安全性比较[J].中国医学物理学杂志,2020,37(12):1494-1497.[doi:DOI:10.3969/j.issn.1005-202X.2020.12.004]
　ZHANG Cuicui,LU Xiaojun,ZHAO Jing.A comparative study on efficacy and safety of 3D conformal radiotherapy with three doses for patients with stage Ⅲ esophageal cancer[J].Chinese Journal of Medical Physics,2020,37(12):1494-1497.[doi:DOI:10.3969/j.issn.1005-202X.2020.12.004]
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3种剂量三维适形放疗对Ⅲ期食管癌患者的疗效与安全性比较()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第12期
页码:
1494-1497
栏目:
医学放射物理
出版日期:
2020-12-30

文章信息/Info

Title:
A comparative study on efficacy and safety of 3D conformal radiotherapy with three doses for patients with stage Ⅲ esophageal cancer
文章编号:
1005-202X（2020）12-1494-04
作者:
张翠翠; 卢晓军; 赵静
空军军医大学第一附属医院， 陕西 西安 710032
Author(s):
ZHANG Cuicui;  LU Xiaojun;  ZHAO Jing
The First Affiliated Hospital of Air Force Medical University, Xian 710032, China
关键词:
食管癌; 三维适形放疗; 放疗剂量; 同步放化疗; 疗效; 安全性
Keywords:
esophageal cancer 3D conformal radiotherapy radiotherapy dose concurrent chemoradiotherapy efficacy safety
分类号:
R811.1；R735.1
DOI:
DOI:10.3969/j.issn.1005-202X.2020.12.004
文献标志码:
A
摘要:
目的：比较3种剂量三维适形放疗（3D-CRT）对Ⅲ期食管癌患者的疗效与安全性。方法：前瞻性选取2016年1月至2018年3月期间收治的99例食管癌同期放化疗患者作为研究对象，随机分为低、中、高剂量组，每组33例，分别给予54、62、68 Gy的3D-CRT治疗及同步化疗。比较3组近期疗效、远期生存状况及安全性。结果：全部患者放疗2个月后无1例肿瘤进展，疾病控制率100%。低剂量组客观缓解率显著低于高剂量组（P<0.05）。全部患者均进行定期随访，截止至2020年5月，中位随访时间为20.5个月（2.5~49.5个月），低、中、高剂量组中位总生存时间（OS）分别为15.16个月（95% CI：8.33~22.89）、28.06个月（95% CI：13.98~42.09）、23.33个月（95% CI：10.06~36.80）。中剂量组中位OS显著高于低剂量组（P<0.05）。安全性方面，全部患者均未出现食管穿孔、放射性脊髓炎等严重并发症，3组患者的不良反应以骨髓抑制最为常见，低剂量组放射性食管炎的发生率显著低于高剂量组（P<0.05）。结论：对于Ⅲ期食管癌同步放化疗患者，62 Gy放疗剂量的3D-CRT综合效果最优，近期疗效与远期生存时间较满意，且安全性较高。
Abstract:
Objective To compare the efficacy and safety of three-dose 3D conformal radiotherapy (3D-CRT) for patients with stage III esophageal cancer. Methods 99 esophageal cancer patients who were treated with concurrent radiotherapy and chemotherapy from January 2016 to March 2018 were retrospectively selected and randomly divided into low, medium, and high dose groups, with 33 cases in each group. Each group was respectively given 3D-CRT 54, 62, and 68 Gy and concurrent chemotherapy. The short-term efficacy, long-term survival status and safety of the three groups were compared. Results There was no tumor progression in all patients after 2 months of radiotherapy, and the disease control rate reached 100%. The objective response rate of the low-dose group was significantly lower than that of the high-dose group (P<0.05). All patients were followed up regularly. As of May 2020, the median follow-up time was 20.5 months (2.5-49.5 months), and the median overall survival time (OS) in the low, medium, and high dose groups was 15.16 months, (95% CI: 8.33-22.89), 28.06 months (95% CI: 13.98-42.09), and 23.33 months (95% CI: 10.06-36.80) respectively. The median OS of the middle-dose group was significantly higher than that of the low-dose group (P<0.05). In terms of safety, none of the patients had serious complications such as esophageal perforation, radiation myelitis, but the bone marrow suppression was the most common adverse reaction in the three groups. The incidence of radiation esophagitis in the low-dose group was significantly lower than that of the high-dose group (P<0.05). Conclusions For patients with stage III esophageal cancer with concurrent radiotherapy and chemotherapy, the 3D-CRT 62 Gy has the best comprehensive effect, with satisfactory short-term efficacy and long-term survival time, and high safety.

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备注/Memo

备注/Memo:
【收稿日期】2020-08-05 【基金项目】陕西省科技计划项目（2018ZDXM-SF-061） 【作者简介】张翠翠，主管护师，E-mail: 252715937@qq.com 【通信作者】卢晓军，主任医师，研究方向：食管癌、肺癌的放射治疗，E-mail: byiyi198198@163.com
更新日期/Last Update: 2020-12-30