[1]曹宏健,刘志成,钱秀清.视乳头的结构和力学特性对筛板变形的影响[J].中国医学物理学杂志,2020,37(10):1317-1322.[doi:DOI:10.3969/j.issn.1005-202X.2020.10.018]
　CAO Hongjian,LIU Zhicheng,QIAN Xiuqing,et al.Effects of mechanical properties and structure of optic nerve head on the deformation of lamina cribrosa[J].Chinese Journal of Medical Physics,2020,37(10):1317-1322.[doi:DOI:10.3969/j.issn.1005-202X.2020.10.018]
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视乳头的结构和力学特性对筛板变形的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第10期
页码:
1317-1322
栏目:
脑科学与神经物理
出版日期:
2020-10-29

文章信息/Info

Title:
Effects of mechanical properties and structure of optic nerve head on the deformation of lamina cribrosa
文章编号:
1005-202X（2020）10-1317-06
作者:
曹宏健1; 刘志成1; 2; 钱秀清1; 2
1.首都医科大学生物医学工程学院， 北京 100069； 2.临床生物力学应用基础研究北京市重点实验室， 北京 100069
Author(s):
CAO Hongjian1;  LIU Zhicheng1;  2;  QIAN Xiuqing1;  2
1. School of Biomedical Engineering, Capital Medical University, Beijing 100069, China 2.Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Beijing 100069, China
关键词:
青光眼; 视乳头; 筛板; 力学特性; 有限元分析
Keywords:
Keywords: glaucoma optic nerve head lamina cribrosa mechanical properties finite element analysis
分类号:
R318.01
DOI:
DOI:10.3969/j.issn.1005-202X.2020.10.018
文献标志码:
A
摘要:
目的：建立包含筛板的全眼球轴对称模型，分析视乳头的结构和力学特性对青光眼患者筛板变形的影响。方法：基于青光眼患者和正常对照组的视乳头结构参数数据，并参考文献结果，建立包含筛板的全眼球轴对称有限元模型；分析视乳头的力学特性和结构参数对筛板变形的影响。结果：眼压升高会导致筛板后移，且随着眼压的升高，筛板变形程度增大。巩膜、筛板和硬脑膜的弹性模量对筛板变形的影响程度较大；且筛板厚度、视杯深度、视杯宽度均对筛板变形有影响。青光眼患者的眼底结构参数、力学特性会使其筛板对眼压和颅压的作用更敏感。结论：有限元方法可用于筛板变形影响因素的研究，为青光眼早期诊断提供参考。
Abstract:
Abstract: Objective To study the effects of mechanical properties and structure of optic nerve head (ONH) on the deformation of lamina cribrosa based on an axisymmetric model of eyeball including lamina cribrosa. Methods An axisymmetric finite element model of eyeball including lamina cribrosa was established based on the geometrical parameters of the ONH of glaucoma patients and normal controls, and with reference to the results of the literature. The effects of mechanical factors and geometrical parameters of ONH on the deformation of lamina cribrosa were analyzed. Results Increased intraocular pressure made lamina cribrosa move backward, and as intraocular pressure was increased, the degree of lamina cribrosa deformation was increased. The Youngs modulus of sclera, lamina cribrosa and dura mater had great effects on the deformation of lamina cribrosa. Moreover, thickness of lamina cribrosa, cup depth and cup width all affected the deformation of lamina cribrosa. Due to the specific structure and mechanical properties of glaucoma patients, the lamina cribrosa of glaucoma patients was more sensitive to intraocular pressure and intracranial pressure. Conclusion The finite element method can be used to study the factors affecting the deformation of lamina cribrosa, thereby providing some reference for the early diagnosis of glaucoma.

相似文献/References:

[1]张迪,宋丽君,刘迪,等.视神经三维结构可视化及定量测量[J].中国医学物理学杂志,2016,33(6):609.[doi:10.3969/j.issn.1005-202X.2016.06.015]
　[J].Chinese Journal of Medical Physics,2016,33(10):609.[doi:10.3969/j.issn.1005-202X.2016.06.015]
[2]王守欣,孙伟健,张昆亚,等. 急性高眼压下猫眼视乳头形态变化[J].中国医学物理学杂志,2017,34(4):399.[doi:DOI:10.3969/j.issn.1005-202X.2017.04.016]
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备注/Memo

备注/Memo:
【收稿日期】2020-06-04 【基金项目】国家自然科学基金（31670964） 【作者简介】曹宏健，研究方向：眼生物力学，E-mail: 13511030152@163.com 【通信作者】钱秀清，博士，教授，E-mail: qianxq@ccmu.edu.cn
更新日期/Last Update: 2020-10-29