[1]黄仁祥,王小辉,郭南萍,等.纯氧及LED阵列光动力复合治疗设备的研制[J].中国医学物理学杂志,2020,37(6):734-742.[doi:DOI:10.3969/j.issn.1005-202X.2020.06.015]
　HUANG Renxiang,WANG Xiaohui,GUO Nanping,et al.Development of a device for photodynamic therapy combining pure oxygen with LED array[J].Chinese Journal of Medical Physics,2020,37(6):734-742.[doi:DOI:10.3969/j.issn.1005-202X.2020.06.015]
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纯氧及LED阵列光动力复合治疗设备的研制()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第6期
页码:
734-742
栏目:
医学信号处理与医学仪器
出版日期:
2020-06-25

文章信息/Info

Title:
Development of a device for photodynamic therapy combining pure oxygen with LED array
文章编号:
1005-202X（2020）06-0734-09
作者:
黄仁祥1; 王小辉2; 郭南萍1; 林珊莉2; 边艳香1; 王炎2; 周宇晖2
1.广州美锐健康产业股份有限公司， 广东 广州 510555； 2.广州生物工程中心， 广东 广州 510630
Author(s):
HUANG Renxiang1;  WANG Xiaohui2;  GUO Nanping1;  LIN Shanli2;  BIAN Yanxiang1;  WANG Yan2;  ZHOU Yuhui2
1. Guangzhou Race Medical & Beauty Equipment Co., Ltd., Guangzhou 510555, China 2. Guangzhou Biotechnology Center, Guangzhou 510630, China
关键词:
光动力疗法; 复合治疗; 单态氧; 透镜阵列; 乏氧; 光排序
Keywords:
Keywords: photodynamic therapy complex treatment singlet oxygen lens array hypoxia light sorting
分类号:
R318.6；R318.51
DOI:
DOI:10.3969/j.issn.1005-202X.2020.06.015
文献标志码:
A
摘要:
基于变压吸附制氧原理产生纯氧，并采用微透镜阵列多光谱LED发光器件与二次透镜阵列相结合构成光动力治疗辐照器，研制一种纯氧及LED阵列光动力复合治疗设备。其辐照器输出纯氧浓度大于90%，照射光包括波长625 nm红光、465 nm蓝光和520 nm绿光，应用光排序辐照技术实现纯氧及多光谱光动力复合治疗。通过辐照器上纯氧和照射光同步输出等多种外源性给氧保持光动力治疗区域的富氧状态，解决由于乏氧影响光动力疗效的问题。辐照器光学系统解决现有技术采用LED阵列排布替代激光器作为光动力治疗光源时存在的光能利用率低、光功率密度分布不均匀、不同波长光束在目标靶面光功率密度分布曲面差异大等缺陷。
Abstract:
Abstract: A novel treatment device for photodynamic therapy combining with pure oxygen and LED array is developed. The device can produce pure oxygen based on the principle of pressure swing adsorption, and there is a photodynamic therapy irradiator established by micro-lens array multi-wavelength LED and secondary lens array. The concentration of pure oxygen output by irradiator is higher than 90%. The light sources include 625 nm red light, 465 nm blue light and 520 nm green light. The pure oxygen combined with multi-spectral photodynamic therapy is realized by light sorting irradiation technology. The problem that the therapeutic effect of photodynamic therapy is affected by the lack of oxygen is solved by a variety of exogenous oxygen such as the synchronous output of pure oxygen and light by the irradiator to maintain the photodynamic therapy area in oxygen-enriched environment. Moreover, the optical system of the irradiator takes LED array arrangement instead of laser as the light source of photodynamic therapy, thereby overcoming the defects of low utilization of light energy, uneven distribution of optical power density and large difference in the optical power density distribution surface of lights of different wavelengths on the target surface.

相似文献/References:

[1]唐琳,李晓原,刘建中,等.蓝光照射姜黄素对乳腺癌MCF-7细胞的光动力杀伤效应研究[J].中国医学物理学杂志,2013,30(03):4200.[doi:10.3969/j.issn.1005-202X.2013.03.025]
[2]汪静文,王静,王娜,等.光动力疗法联合钬激光治疗尖锐湿疣的疗效与安全性[J].中国医学物理学杂志,2023,40(4):469.[doi:DOI:10.3969/j.issn.1005-202X.2023.04.012]
　WANG Jingwen,WANG Jing,WANG Na,et al.Therapeutic efficacy and safety of photodynamic therapy combined with holmium laser in condyloma acuminatum[J].Chinese Journal of Medical Physics,2023,40(6):469.[doi:DOI:10.3969/j.issn.1005-202X.2023.04.012]

备注/Memo

备注/Memo:
【收稿日期】2020-03-12 【基金项目】国家重点研发计划（2019YFC0118804）；广州市对外科技合作计划项目（201807010009） 【作者简介】黄仁祥，高级工程师，主要从事生物医学工程、光动力治疗技术等方面研究，E-mail: 2861610521@qq.com；王小辉，研究员，主要从事光电技术、有源医疗仪器等方面研究，E-mail: 503225328@qq.com
更新日期/Last Update: 2020-07-03