[1]陆世培,陈昱汐,盘茵琳,等.摆位误差对肝癌立体定向放射治疗剂量学的影响[J].中国医学物理学杂志,2020,37(11):1360-1366.[doi:DOI:10.3969/j.issn.1005-202X.2020.11.004]
 LU Shipei,CHEN Yuxi,PAN Yinlin,et al.Effects of setup error on the dosimetry of stereotactic body radiotherapy for liver cancer[J].Chinese Journal of Medical Physics,2020,37(11):1360-1366.[doi:DOI:10.3969/j.issn.1005-202X.2020.11.004]
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摆位误差对肝癌立体定向放射治疗剂量学的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第11期
页码:
1360-1366
栏目:
医学放射物理
出版日期:
2020-12-02

文章信息/Info

Title:
Effects of setup error on the dosimetry of stereotactic body radiotherapy for liver cancer
文章编号:
1005-202X(2020)11-1360-07
作者:
陆世培1陈昱汐12盘茵琳123黄思娟1杨鑫1
1.中山大学肿瘤防治中心/华南肿瘤学国家重点实验室/肿瘤医学协同创新中心/广东省鼻咽癌诊治研究重点实验室, 广东 广州 510060; 2.中山大学新华学院, 广东 广州 510520; 3.广州医科大学附属肿瘤医院, 广东 广州 510095
Author(s):
LU Shipei1 CHEN Yuxi1 2 PAN Yinlin1 2 3 HUANG Sijuan1 YANG Xin1
1. Cancer Center of Sun Yat-sen University/State Key Laboratory of Oncology in South China/Collaborative Innovation Center for Cancer Medicine/Guangdong Provincial Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, China 2. Xinhua College of Sun Yat-sen University, Guangzhou 510520, China 3. Cancer Center of Guangzhou Medical University, Guangzhou 510095, China
关键词:
肝癌图像引导放射治疗立体定向放射治疗摆位误差剂量学
Keywords:
Keywords: liver cancer image-guided radiotherapy stereotactic body radiotherapy setup error dosimetry
分类号:
R735.7;R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2020.11.004
文献标志码:
A
摘要:
目的:在锥形束CT(CBCT)图像引导下,测量立体定向放射治疗(SBRT)中肝癌的摆位误差,并讨论摆位误差对靶区PTV和危及器官(OAR)剂量的影响。方法:回顾性分析接受SBRT的肝癌患者13例,每日放射治疗前行CBCT扫描,与计划CT图像进行灰度配准,根据肿瘤靶区及OAR位置获取患者移床参数,在计划系统中计算剂量分布,并分析移床参数对靶区PTV、OAR剂量和均匀性指数(HI)、适形度指数(CI)等一系列剂量学参数的影响。结果:校正后X、Y、Z方向上的摆位误差分别为(0.47±2.00)、(1.54±4.16)、(0.10±2.77) mm,Y方向上的摆位误差较大。相对于最小位移,最大位移对靶区、HI和CI影响大;对于OAR,与原始计划相比,左肾、小肠最大位移的剂量分布在Dmean、Dmax上具有统计学意义,右肾最小位移的剂量分布在Dmean上具有统计学意义。结论:≤3 mm的摆位误差对靶区剂量的影响比>5 mm的影响小,但对于最小剂量和覆盖率仍然影响显著。应该尽可能减小摆位误差,以实现精确放疗。
Abstract:
Abstract: Objective Under the guidance of cone-beam CT (CBCT) images, the setup error of stereotactic body radiotherapy (SBRT) for liver cancer was measured, and the effect of setup error on the PTV and organ-at-risk (OAR) dose in the target area was discussed. Methods 13 liver cancer patients who received SBRT was reviewed retrospectively. CBCT image was taken before each daily radiotherapy and then the gray-scale registration was done with the planning CT images. Based on the coach shifting parameters from the tumor target area and OAR position,the dose distribution in the planning system was calculated, and the effects of coach shifting parameters on a series of dosimetric parameters such as PTV, OAR dose, uniformity index (HI), and conformity index (CI) was analyzed. Results After correction, the setup errors in X, Y and Z directions are (0.47±2.00), (1.54±4.16) and (0.10±2.77) mm respectively, and the setup error is larger in Y direction. Compared with the minimum displacement, the maximum displacement has a significant effect on the target area, HI and CIF. As for OARs, compared with the original plan, the dose distribution of the maximum displacement in the left kidney and small intestine is statistically significant in the Dmean and Dmax, and the dose distribution of the minimum displacement in the right kidney is statistically significant in the Dmean. Conclusion The effect of setup error ≤3 mm on the dose of target area is smaller than that >5 mm, but the effect still has a significant impact on the minimum dose and coverage rate. In order to achieve accurate radiotherapy, the setup error should be minimized as much as possible.

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备注/Memo

备注/Memo:
【收稿日期】2020-03-24 【基金项目】广州市珠江科技新星专项(201710010162);广东省自然科学基金(2017A030310217);“医学信息分析及肿瘤诊疗湖北省重点实验室”开放课题(PJS140011504);大学生创新创业训练计划项目(202013902065, 202013902062, 20191390109, 201813902075, 201813902071, 201713902050) 【作者简介】陆世培,放射治疗技师,研究方向:肿瘤放射治疗技术、放疗质控质保,E-mail: lushp@sysucc.org.cn 【通信作者】杨鑫,博士,硕士生导师,助理研究员,研究方向:医学物理、生物医学工程、放疗质控质保,E-mail: yangxin@sysucc.org.cn
更新日期/Last Update: 2020-12-02