[1]杨丽姝,刘丽珠,韩波.肿瘤治疗电场的微观机制及临床应用进展[J].中国医学物理学杂志,2021,38(7):883-888.[doi:DOI:10.3969/j.issn.1005-202X.2021.07.018]
　YANG Lishu,LIU Lizhu,HAN Bo.Micromechanism of tumor treating fields and advances in its clinical application[J].Chinese Journal of Medical Physics,2021,38(7):883-888.[doi:DOI:10.3969/j.issn.1005-202X.2021.07.018]
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肿瘤治疗电场的微观机制及临床应用进展()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第7期
页码:
883-888
栏目:
医学生物物理
出版日期:
2021-07-26

文章信息/Info

Title:
Micromechanism of tumor treating fields and advances in its clinical application
文章编号:
1005-202X（2021）07-0883-06
作者:
杨丽姝; 刘丽珠; 韩波
哈尔滨医科大学附属第一医院肿瘤科， 黑龙江 哈尔滨 150001
Author(s):
YANG Lishu;  LIU Lizhu;  HAN Bo
Department of Oncology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
关键词:
肿瘤治疗电场; 有丝分裂; 胶质母细胞瘤; 恶性肿瘤
Keywords:
tumor treating fields mitosis glioblastoma malignant tumor
分类号:
R318；R73-33
DOI:
DOI:10.3969/j.issn.1005-202X.2021.07.018
文献标志码:
A
摘要:
肿瘤治疗电场（TTFields）使用非侵入式一次性传感器阵列提供低强度、中频、交变电场干扰细胞有丝分裂导致发生应激、凋亡及增值抑制，达到局部治疗肿瘤的目的。TTFields通过干扰微管蛋白二聚体在微管上的正常组装和拆卸来破坏有丝分裂期肿瘤细胞的染色体分离；通过对Septin蛋白复合物、非肌肉肌球蛋白II和纤维型肌动蛋白等具有高偶极矩的蛋白质施加旋转、扭转应力等物理力破坏卵裂沟的形成和收缩；通过在有丝分裂细胞内形成的不均匀电场诱发介电泳现象破坏细胞质的分离。TTFields对于不同的细胞具有不同的敏感参数，对静止期细胞则没有作用。TTFields与化疗联合应用具有相加或协同作用，可以提高疗效。TTFields具有创伤小、副作用较小的优势，安全性和有效性在胶质母细胞瘤的III期临床试验中得到验证，在其它多种癌症也开展了临床研究。
Abstract:
Tumor treating fields (TTFields) uses a non-invasive disposable sensor array to provide low-intensity, intermediate frequency, alternating electric field for interfering with cell mitosis, and leading to stress, apoptosis and inhibition of cell proliferation, thereby achieving the purpose of local treatment of tumors. TTFields can destroy the chromosome segregation of mitotic tumor cells by disturbing the normal assembly and disassembly of α/β-tubulin on microtubules, disturb the formation and contraction of cell cleavage furrow by applying physical forces such as rotation and torsion stresses on the proteins with high dipole moment such as Septin complex, non-muscle myosin II and F-actin, and disrupt the cytoplasmic separation by dielectrophoresis induced by uneven electric fields in mitotic cells. The sensitive parameters of TTFields for various cells are different, but TTFields has no effect on quiescent cells. The combination of TTFields and chemotherapy has additive or synergistic effect, thus further improving curative effect. TTFields has the advantages of less trauma and fewer side effects, and its safety and effectiveness have been verified in phase III clinical trials of glioblastoma. Some clinical trials on TTFields have also been carried out in other kinds of cancer.

相似文献/References:

[1]许彦龙,李国强,余跃,等.肿瘤电场治疗在胶质母细胞瘤治疗中的应用进展[J].中国医学物理学杂志,2021,38(5):647.[doi:DOI:10.3969/j.issn.1005-202X.2021.05.023]
　XU Yanlong,,et al.Advances in application of tumor treating fields in glioblastoma[J].Chinese Journal of Medical Physics,2021,38(7):647.[doi:DOI:10.3969/j.issn.1005-202X.2021.05.023]
[2]胡小洋,韩磊,汪洋,等.TTF电极阵列及头皮保护技术对放疗剂量分布影响的初步研究[J].中国医学物理学杂志,2022,39(2):169.[doi:DOI:10.3969/j.issn.1005-202X.2022.02.007]
　HU Xiaoyang,HAN Lei,WANG Yang,et al.Preliminary study on the effects of electrodes array for tumor treating fields and scalp sparing technology on the dose distribution in radiotherapy[J].Chinese Journal of Medical Physics,2022,39(7):169.[doi:DOI:10.3969/j.issn.1005-202X.2022.02.007]

备注/Memo

备注/Memo:
【收稿日期】2021-03-01 【基金项目】黑龙江省卫生计生委科研课题（2018257） 【作者简介】杨丽姝，硕士，主治医师，主要从事中枢神经系统肿瘤及头颈部肿瘤的放化疗及综合治疗，E-mail: 243678038@qq.com 【通信作者】刘丽珠，硕士，主治医师，主要从事肺癌的放化疗及综合治疗，E-mail: Lizhu8215@163.com
更新日期/Last Update: 2021-07-26