[1]鲜利勋,李光俊,肖青,等.基于食管癌放疗的剂量学参数研究几何指标评价自动勾画轮廓准确度的可行性[J].中国医学物理学杂志,2021,38(2):148-152.[doi:DOI:10.3969/j.issn.1005-202X.2021.02.004]
　XIAN Lixun,LI Guangjun,XIAO Qing,et al.Feasibility study of evaluating autosegmentation accuracy with geometric indices based on dosimetric parameters of esophageal cancer radiotherapy[J].Chinese Journal of Medical Physics,2021,38(2):148-152.[doi:DOI:10.3969/j.issn.1005-202X.2021.02.004]
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基于食管癌放疗的剂量学参数研究几何指标评价自动勾画轮廓准确度的可行性()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第2期
页码:
148-152
栏目:
医学放射物理
出版日期:
2021-02-02

文章信息/Info

Title:
Feasibility study of evaluating autosegmentation accuracy with geometric indices based on dosimetric parameters of esophageal cancer radiotherapy
文章编号:
1005-202X（2021）02-0148-05
作者:
鲜利勋1; 2; 李光俊1; 肖青1; 陈黎1; 胡臻尧1; 柏森1; 2
1.四川大学华西医院放疗科， 四川 成都 610041； 2.四川大学物理科学与技术学院， 四川 成都 610065
Author(s):
XIAN Lixun1; 2;  LI Guangjun1;  XIAO Qing1;  CHEN Li1;  HU Zhenyao1;  BAI Sen1;  2
1.Department of Radiotherapy, West China Hospital of Sichuan University, Chengdu 610041, China 2. School of Physical Science and Technology, Sichuan University, Chengdu 610065, China
关键词:
食管癌; 放射治疗; 自动勾画软件; 危及器官; 几何指标; 剂量学参数
Keywords:
Keywords: esophageal cancer Atlas-based autosegmentation organs-at-risk geometric index dosimetric parameter
分类号:
R318；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2021.02.004
文献标志码:
A
摘要:
目的：探讨几何指标HD、HDmean、HD95%、DSC、Jaccard间的差异，并结合食管癌放疗的剂量学参数研究几何指标评估自动勾画轮廓准确度的临床可行性。方法：选取在四川大学华西医院放疗科接受放射治疗的15例食管癌患者作为研究对象，采用ABAS软件勾画双肺、脊髓、心脏等结构，将高年资医生修改、审核后的轮廓视为参考轮廓。在参考轮廓产生的原剂量分布图上获取相应的自动勾画结构的剂量学参数，利用线性回归R?量化几何指标与剂量学参数间的相关性。结果：距离类几何指标（0~44.7 mm）波动范围较体积类指标（0.7~1.0）大；几何指标与剂量学参数间的相关性，强弱各异且不一致（45%存在相关性, P<0.05）。结论：剂量学参数深受轮廓所在位置、轮廓差异的影响，凸显了它在临床评估过程中的重要性，也表明仅用几何指标是不可靠的，建议与剂量学参数相结合。
Abstract:
Abstract: Objective To explore the differences among geometric indices HD, HDmean, HD95%, DSC and Jaccard, and to study the clinical feasibility of evaluating autosegmentation accuracy with geometric indices based on the dosimetric parameters in esophageal cancer radiotherapy. Methods Fifteen patients with esophageal cancer who received radiotherapy in Department of Radiotherapy, West China Hospital of Sichuan University were selected as the research objects, and their lungs, spinal cord and heart were outlined using Atlas-based autosegmentation software. The contours modified and reviewed by senior doctors were regarded as the references. The dosimetric parameters of the corresponding automatically-segmented structures were obtained on the original dose distribution map generated by the reference contours, and the linear regression R?was used to quantify the correlation between geometric indices and dosimetric parameters. Results The fluctuation range of distance-related geometric indices (0-44.7 mm) was larger than that of volume-related indices (0.7-1.0). The correlations between geometric indices and dosimetric parameters were different (45% correlated, P<0.05) and inconsistent. Conclusion The dosimetric parameter is deeply affected by the locations and differences of contours, which highlights its importance in clinical evaluation and shows that it is not reliable to use geometric indices only for clinical evaluation. The combination of geometric indices and dosimetric parameters is recommended for clinical evaluation.

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备注/Memo

备注/Memo:
【收稿日期】2020-08-12 【基金项目】国家自然科学基金（81472807） 【作者简介】鲜利勋，硕士研究生，研究方向：肿瘤放疗物理，E-mail:1271322836@qq.com 【通信作者】柏森，主任技师，研究方向：肿瘤放疗物理，E-mail: baisen@scu.edu.cn
更新日期/Last Update: 2021-02-02