[1]包星星,赵璨,包书圣,等.基于病理“金标准”标记脊髓损伤慢性期MRI图像坏死区域的方法[J].中国医学物理学杂志,2020,37(11):1373.
　BAO Xingxing,ZHAO Can,BAO Shusheng,et al.Study on the method of marking the necrotic area of MRI image in chronic spinal cord injury based on pathological “gold standard”[J].Chinese Journal of Medical Physics,2020,37(11):1373.
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基于病理“金标准”标记脊髓损伤慢性期MRI图像坏死区域的方法()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第11期
页码:
1373
栏目:
医学影像物理
出版日期:
2020-12-02

文章信息/Info

Title:
Study on the method of marking the necrotic area of MRI image in chronic spinal cord injury based on pathological “gold standard”
作者:
包星星1; 赵璨2; 3; 包书圣1; 饶家声1; 3; 杨朝阳3; 4; 李晓光1; 3; 4
1.北京航空航天大学生物与医学工程学院/生物材料与神经再生北京市重点实验室， 北京 100083； 2.中国康复科学所康复工程研究所， 北京 100068； 3.北京航空航天大学生物医学工程高精尖创新中心， 北京 100083； 4.首都医科大学基础医学院/神经生物学系， 北京 100069
Author(s):
BAO Xingxing1;  ZHAO Can2;  3;  BAO Shusheng1;  RAO Jiasheng1;  3;  YANG Zhaoyang3;  4;  Li Xiaoguang1;  3;  4
1. School of Biological Science and Medical Engineering, Beihang University/Beijing Key Laboratory of Biomaterials and Neural Regeneration, Beijing 100083, China 2. Institute of Rehabilitation Engineering, China Rehabilitation Science Institute, Beijing 100068, China 3. Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China 4. Department of Neurobiology/School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
关键词:
脊髓损伤慢性期; 磁共振成像; 病理切片; 坏死区域; 标记
Keywords:
Keywords: chronic spinal cord injury MRI pathological sections necrotic area mark
文献标志码:
A
摘要:
脊髓损伤慢性期胶质瘢痕及其所包绕的囊腔所构成的脊髓坏死区域在磁共振成像（MRI）中形态各异，边界模糊。针对单纯根据图像无法准确识别脊髓坏死区域这一问题，提出一种基于病理切片“金标准”来标记MRI图像实际坏死区域的方法。双边滤波去噪并刚体配准脊髓损伤慢性期的多模态MRI图像，使用Snake模型进行脊髓的分离，并利用双三次插值法对脊髓进行拉直。采用双树复小波变换融合不同模态的图像后，基于病理切片的胶质瘢痕及囊腔区域与MRI图像的脊髓坏死区域具有空间相对位置一致性的特点，建立从脊髓病理切片到MRI图像的空间映射关系，最终实现MRI图像中实际坏死区域的标记。以圆度和偏心率作为形状评价指标，对本方法标记的MRI坏死区域与病理切片“金标准”结果进行对比，相似度分别达到了0.93±0.03和0.97±0.02。结果表明，应用本方法构建的映射关系能较为准确、客观地标记MRI图像的实际坏死区域，为后期计算机自动识别与分割MRI坏死区域奠定基础。
Abstract:
Abstract: In the chronic stage of spinal cord injury, the area of spinal cord necrosis constituted by glial scar and its surrounding cystic cavity, usually presents different shapes and fuzzy bounders in magnetic resonance imaging (MRI). To solve the problem that the area of spinal necrosis can not be accurately identified based on the image alone, a method based on the “gold standard” of pathological section is proposed to help mark the actual area of spinal necrosis in MRI image. In the multi-modal MRI images of chronic spinal cord injury denoised by bilateral filter and registered by rigid body, the spinal cord is separated by the snake model and straightened by the bicubic interpolation method. After fusing images of different modes with dual tree-complex wavelet transform, the glial scar and cystic area based on pathological section have the consistent characteristics in relative spatial position with the spinal necrosis area of MRI image. The spatial mapping relationship between pathological section of spinal cord and MRI image is established, and finally the marking of actual necrosis area in MRI image is realized. With roundness and eccentricity as shape evaluation indexes, the MRI necrosis areas marked by this method are compared with the results based on “gold standard” of pathological sections, and the similarity was found to be 0.93±0.03 and 0.97±0.02 respectively. The results show that the mapping relationship constructed by this method can accurately and objectively mark the actual necrotic areas of MRI images, which lays a foundation for the automatic recognition and segmentation of MRI necrotic areas in the later stage.

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更新日期/Last Update: 2020-12-02