[1]邵莹,王雅棣,王石,等.不同优化方法在乳腺癌大分割放疗中的剂量学研究[J].中国医学物理学杂志,2020,37(7):843-849.[doi:DOI:10.3969/j.issn.1005-202X.2020.07.009]
　SHAO Ying,WANG Yadi,WANG Shi,et al.Different optimization methods in hypofractionated radiotherapy for breast cancer: a dosimetric study[J].Chinese Journal of Medical Physics,2020,37(7):843-849.[doi:DOI:10.3969/j.issn.1005-202X.2020.07.009]
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不同优化方法在乳腺癌大分割放疗中的剂量学研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第7期
页码:
843-849
栏目:
医学放射物理
出版日期:
2020-07-25

文章信息/Info

Title:
Different optimization methods in hypofractionated radiotherapy for breast cancer: a dosimetric study
文章编号:
1005-202X（2020）07-0843-07
作者:
邵莹1; 2; 王雅棣1; 王石3; 张富利1
1.解放军总医院第七医学中心放疗科， 北京 100700； 2.清华大学附属北京清华长庚医院放疗科， 北京 102218； 3.清华大学工物系， 北京 100084
Author(s):
SHAO Ying1; 2;  WANG Yadi1;  WANG Shi3;  ZHANG Fuli1
1. Department of Radiotherapy, the Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China 2. Department of Radiotherapy, Beijing Tsinghua Changgung Hospital Affiliated to Tsinghua University, Beijing 102218, China 3. Department of Engineering Physics, Tsinghua University, Beijing 100084, China
关键词:
乳腺癌; 等效均匀剂量; 大分割放疗; 剂量学
Keywords:
Keywords: breast cancer equivalent uniform dose hypofractionated radiotherapy dosimetry
分类号:
R737.9；R815
DOI:
DOI:10.3969/j.issn.1005-202X.2020.07.009
文献标志码:
A
摘要:
目的：探讨物理函数优化与生物函数优化在乳腺癌大分割放疗计划中的剂量学差异。方法：选择已接受放疗的15例左侧乳腺癌病例，分别对每个病例使用物理函数（DV组）、生物函数-物理函数相结合（DV+EUD组、EUD+DV组）及生物函数（EUD组）优化方法重新进行容积旋转调强放疗计划设计。通过计算与分析各项剂量学参数来评估4组优化方法在乳腺癌大分割放疗中的剂量学差异。结果：含生物函数的优化结果与仅含物理函数的优化结果比较具有统计学差异（P<0.05）。EUD组与EUD+DV组的靶区剂量学结果接近，且靶区EUD与肿瘤控制率明显高于DV组与DV+EUD组。另外，EUD组的患侧肺剂量明显低于其余3组，与DV组和DV+EUD组相比，机器跳数也降低了约16%。结论：生物函数在提高靶区EUD与肿瘤控制率以及保护患侧肺组织方面都具有明显优势，并可提高治疗实施效率。可以使用生物函数优化方法进行乳腺癌计划的优化。
Abstract:
Abstract: Objective To discuss the dosimetric differences in hypofractionated radiotherapy plans for breast cancer optimized by physical functions versus biological functions. Methods Fifteen left-sided breast cancer patients underwent radiotherapy were enrolled in the study. The volumetric modulated arc therapy plans of the patients were respectively designed with physical functions (DV group), biological-physical functions (DV+EUD group and EUD+DV group) and biological functions (EUD group). The dosimetric differences among 4 optimization methods in the hypofractionated radiotherapy for breast cancer were evaluated by calculating and analyzing dosimetric parameters. Results There were statistical differences between plans optimized by biological functions (EUD, EUD+DV, DV+EUD groups) and the plan only optimized by physical functions (DV group) (P<0.05). The dosimetric results of target areas in EUD group and EUD+DV group were similar, and the EUD and tumor control probability of target areas in the two groups were higher than those in DV group and DV+EUD group. Moreover, the dose of the ipsilateral lung in EUD group was less than that in the other 3 groups, and MU was 16% lower than DV group and DV+EUD group. Conclusion Biological functions not only have significant advantages in improving the EUD and tumor control probability of target areas and protecting the ipsilateral lung, but also improve treatment efficiency. Biological functions can be used to optimize the treatment plan for breast cancer.

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备注/Memo

备注/Memo:
【收稿日期】2020-02-17 【基金项目】北京市科技计划项目 （Z181100001718011） 【作者简介】邵莹，硕士，物理师，研究方向：医学物理，E-mail: shaoying927@126.com 【通信作者】张富利，Email: radiozfli@163.com
更新日期/Last Update: 2020-07-28