[1]李华玲,王沛沛,李金凯,等.体积对自动勾画软件勾画危及器官准确性的影响[J].中国医学物理学杂志,2020,37(7):797-802.[doi:DOI:10.3969/j.issn.1005-202X.2020.07.001]
　LI Hualing,WANG Peipei,LI Jinkai,et al.Effect of volume on the accuracy of organs-at-risk segmentation by automatic segmentation software[J].Chinese Journal of Medical Physics,2020,37(7):797-802.[doi:DOI:10.3969/j.issn.1005-202X.2020.07.001]
点击复制

体积对自动勾画软件勾画危及器官准确性的影响()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第7期
页码:
797-802
栏目:
医学放射物理
出版日期:
2020-07-25

文章信息/Info

Title:
Effect of volume on the accuracy of organs-at-risk segmentation by automatic segmentation software
文章编号:
1005-202X（2020）07-0797-06
作者:
李华玲1; 王沛沛2; 李金凯2; 李彩虹2; 昌志刚2; 顾宵寰2; 孙新臣2; 曹远东2
1.南京医科大学特种医学系， 江苏 南京 210009； 2.南京医科大学第一附属医院放疗科， 江苏 南京 210009
Author(s):
LI Hualing1;  WANG Peipei2;  LI Jinkai2;  LI Caihong2;  CHANG Zhigang2;  GU Xiaohuan2;  SUN Xinchen2;  CAO Yuandong2
1. Department of Special Medicine, Nanjing Medical University, Nanjing 210009, China 2. Department of Radiation Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China
关键词:
AccuContour自动勾画软件; 危及器官; 体积; 几何准确性
Keywords:
Keywords: AccuContour automatic segmentation software organs-at-risk volume geometric accuracy
分类号:
R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2020.07.001
文献标志码:
A
摘要:
【摘要】目的：评价基于人工智能的自动勾画系统（AccuContour自动勾画软件）对危及器官（OAR）勾画的几何准确性，探讨OAR自动勾画的几何准确性是否受OAR体积的影响。方法：选取161例患者，其中头颈部、胸部、盆腔肿瘤患者各40例，腹部肿瘤患者41例。分别采用AccuContour自动勾画软件和手动勾画的方式对晶体、视神经、眼球、垂体、脑干、腮腺、下颌骨、双肺、心脏、双肾、肝脏、直肠、膀胱、股骨头等部位进行勾画。统计各个勾画部位的戴斯相似系数（DSC）、豪斯多夫距离（HD）、Jaccard系数以及体积这4项参数，并使用DSC、Jaccard系数和HD评价自动勾画的几何准确性。对DSC、HD、Jaccard系数与体积进行Spearman相关性分析，并对晶体、视神经、眼球、腮腺、颞颌关节、双肺、双肾、股骨头等成对部位的DSC、HD、Jaccard系数之间进行Wilcoxon配对秩和检验。结果：各个部位的DSC均数均大于0.7；头颈部的Jaccard系数均数为0.557~0.880，其中最低的为右视神经，最高的为下颌骨。头颈部、胸部、盆腔的HD均数分别小于8、22、16 mm；除肝脏（HD=34.563 mm）外，腹部其他部位的HD均数均小于19 mm。DSCall、Jaccardall系数及HDall的大小与体积具有相关性（rDSC=0.757, PDSC=0.000；rJaccard=0.775, PJaccard=0.000；rHD=0.761, PHD=0.000）。晶体、视神经、眼球、垂体、脑干、腮腺、下颌骨、双肺、膀胱、股骨头等部位的DSC和Jaccard系数与OAR体积具有相关性（P<0.05），HD与体积不具有相关性（P>0.05）。双肺之间的DSC和Jaccard系数差异具有统计学意义（PDSC＝0.000, PJaccard＝0.000）。结论：AccuContour自动勾画软件对于OAR的勾画具有较高的准确性，自动勾画的几何准确性受OAR体积大小的影响。
Abstract:
Abstract: Objective To evaluate the geometric accuracy of artificial intelligence-based automatic segmentation system (AccuContour automatic segementation software) for the segmentation of organs-at-risk and to investigate whether the geometric accuracy of automatic OAR segmentation is affected by the volume of OAR. Methods A total of 161 patients were enrolled, including 40 cases with tumor in head and neck, chest, and pelvis, and 41 cases with tumor in the abdomen. AccuContour automatic segementation software and manual delineation were used to contour lens, optic nerve, eyeball, pituitary, brainstem, parotid glands, mandible, lungs, heart, kidneys, liver, rectum, bladder, femoral heads and other OAR. The Dice similarity coefficient (DSC), Hausdorff distance (HD), Jaccard coefficient and volume of each segmented OAR were analyzed, and the geometric accuracy of the automatic segmentation was evaluated using DSC, Jaccard coefficient and HD. Spearman correlation analysis was used to verify the correlations between volume and DSC, HD, Jaccard coefficient and Wilcoxon paired rank sum test was conducted on the DSC, HD and Jaccard coefficients of paired OAR such as lens, optic nerves, eyeballs, parotid glands, temporomandibular joints, lungs, kidneys and femoral heads, etc. Results The mean DSC of each OAR was larger than 0.7. The mean Jaccard coefficient of the neck was between 0.557 and 0.880, with the lowest Jaccard coefficient in the right optic nerve and the highest in the mandible. The mean HD of head and neck, chest, and pelvis was less than 8, 22 and 16 mm, respectively. Except for the liver (HD=34.563 mm), the other OAR in the abdomen had a HD less than 19 mm. There were correlations between volume and DSCall, Jaccardall coefficient, HDall (rDSC=0.757, PDSC=0.000 rJaccard=0.775 PJaccard=0.000 rHD=0.761, PHD=0.000). The DSC and Jaccard coefficient of lens, optic nerves, eyeballs, pituitary, brainstem, parotid glands, mandible, lungs, bladder, femoral heads, etc. were also correlated with the volume of OAR (P<0.05), but their HD was not related to volume (P>0.05). The differences in DSC and Jaccard coefficient between bilateral lungs were statistically significant (PDSC =0.000, PJaccard=0.000). Conclusion AccuContour automatic segmentation software has a high accuracy for OAR segmentation, and the geometric accuracy of automatic segmentation is affected by the volume of OAR.

相似文献/References:

[1]蒋晓芹,段宝风,艾平,等.基于图谱库的自动轮廓勾画软件(ABAS)在鼻咽癌调强放疗中的应用[J].中国医学物理学杂志,2013,30(02):3997.[doi:10.3969/j.issn.1005-202X.2013.02.008]
[2]倪千喜,唐迪红,张九堂,等.妇科肿瘤后装逆向调强放射治疗的剂量学和疗效研究[J].中国医学物理学杂志,2013,30(06):4487.[doi:10.3969/j.issn.1005-202X.2013.06.005]
[3]张艺宝,吴昊,李莎,等.临床前验证与几何对比分析基于图谱库的危及器官自动勾画[J].中国医学物理学杂志,2015,32(06):761.[doi:doi:10.3969/j.issn.1005-202X.2015.06.001]
　[J].Chinese Journal of Medical Physics,2015,32(7):761.[doi:doi:10.3969/j.issn.1005-202X.2015.06.001]
[4]叶柳清,洪文松,黎静,等.不同图像灰度-密度校准曲线对螺旋断层放疗系统剂量计算的影响[J].中国医学物理学杂志,2016,33(5):505.[doi:10.3969/j.issn.1005-202X.2016.05.015]
　[J].Chinese Journal of Medical Physics,2016,33(7):505.[doi:10.3969/j.issn.1005-202X.2016.05.015]
[5]吴昊,蒋璠,岳海振,等.瓦里安RapidPlan模型训练中统计离群值的处理及其剂量学影响[J].中国医学物理学杂志,2016,33(7):649.[doi:10.3969/j.issn.1005-202X.2016.07.001]
　[J].Chinese Journal of Medical Physics,2016,33(7):649.[doi:10.3969/j.issn.1005-202X.2016.07.001]
[6]王贝,全红,邱杰,等. 容积旋转调强技术用于直肠癌时最佳机架角度设置研究[J].中国医学物理学杂志,2016,33(9):898.[doi:10.3969/j.issn.1005-202X.2016.09.006]
　[J].Chinese Journal of Medical Physics,2016,33(7):898.[doi:10.3969/j.issn.1005-202X.2016.09.006]
[7]曹洋森,于春山,孙永健,等.Monaco两种优化模式在前列腺癌容积旋转调强中的剂量学比较[J].中国医学物理学杂志,2016,33(11):1126.[doi:10.3969/j.issn.1005-202X.2016.11.009]
　[J].Chinese Journal of Medical Physics,2016,33(7):1126.[doi:10.3969/j.issn.1005-202X.2016.11.009]
[8]戴相昆,曲宝林,杜乐辉,等.断层径照技术在非小细胞肺癌放疗中的应用[J].中国医学物理学杂志,2017,34(2):126.[doi:10.3969/j.issn.1005-202X.2017.02.004]
　Application of Tomo Direct in the radiotherapy of non-small cell lung cancer[J].Chinese Journal of Medical Physics,2017,34(7):126.[doi:10.3969/j.issn.1005-202X.2017.02.004]
[9]张富利,许卫东,蒋华勇,等.不同类型多叶准直器对左侧乳腺癌保乳术后容积旋转调强放疗技术剂量分布的影响[J].中国医学物理学杂志,2017,34(7):726.[doi:10.3969/j.issn.1005-202X.2017.07.015]
　[J].Chinese Journal of Medical Physics,2017,34(7):726.[doi:10.3969/j.issn.1005-202X.2017.07.015]
[10]薛涛,刘光波,袁香坤,等. 宫颈癌近距离腔内放射治疗中膀胱和直肠ICRU参考点剂量和体积剂量受量比较[J].中国医学物理学杂志,2017,34(9):897.[doi:DOI:10.3969/j.issn.1005-202X.2017.09.008]
　[J].Chinese Journal of Medical Physics,2017,34(7):897.[doi:DOI:10.3969/j.issn.1005-202X.2017.09.008]

备注/Memo

备注/Memo:
【收稿日期】2020-01-20 【基金项目】国家自然科学基金（81672983，81703027） 【作者简介】李华玲，硕士研究生，研究方向：医学物理，E-mail: 2361507891@qq.com 【通信作者】曹远东，博士，副教授，研究方向：肿瘤精准放疗，E-mail: yuandongcao@163.com
更新日期/Last Update: 2020-07-28